A 192 bp ERV fragment insertion in the first intron of porcine TLR6 may act as an enhancer associated with the increased expressions of TLR6 and TLR1 [PDF]
Mobile DNA, 2021 Background Toll-like receptors (TLRs) play important roles in building innate immune and inducing adaptive immune responses. Associations of the TLR genes polymorphisms with disease susceptibility, which are the basis of molecular breeding for disease ...
XiaoYan Wang +9 more
doaj +3 more sources
CopE and TLR6 RNAi-mediated tomato resistance to western flower thrips
Journal of Integrative Agriculture, 2023 The western flower thrips (WFT; Frankliniella occidentalis) is a mesophyll cell feeder that damages many crops. Management of WFT is complex due to factors such as high fecundity, short reproduction time, ability to feed on a broad range of host plants ...
Jelli VENKATESH +5 more
doaj +2 more sources
Gene conversion limits divergence of mammalian TLR1 and TLR6 [PDF]
BMC Evolutionary Biology, 2007 Background Toll-like receptors (TLR) recognize pathogen-associated molecular patterns and are important mediators of the innate immune system. TLR1 and TLR6 are paralogs and located in tandem on the same chromosome in mammals. They form heterodimers with
Dunoyer-Geindre Sylvie +4 more
doaj +4 more sources
Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists [PDF]
Journal of Lipid Research, 2012 Atherosclerosis is a chronic inflammatory vascular disease. Toll-like receptors (TLRs) are major initiators of inflammation. TLR2 promotes atherosclerosis in LDL receptor (LDLr)-deficient mice fed a high-fat diet (HFD).
Linda K. Curtiss +3 more
doaj +3 more sources
Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists [PDF]
Molecules, 2019 Cancer vaccine is a promising immunotherapeutic approach to train the immune system with vaccines to recognize and eliminate tumors. Adjuvants are compounds that are necessary in cancer vaccines to mimic an infection process and amplify immune responses.
Yang Zhou +3 more
doaj +3 more sources
The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6. [PDF]
Veterinary Research, 2013 TLR2 recognises bacterial lipopeptides and lipoteichoic acid, and forms heterodimers with TLR1 or TLR6. TLR2 is relatively well characterised in mice and humans, with published crystal structures of human TLR2/1/Pam3CSK4 and murine TLR2/6/Pam2CSK4 ...
Bryant, Clare Elizabeth +3 more
core +5 more sources
BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer
Inflammation Research, 2023 Abstract Objective and design BacSp222 bacteriocin is a bactericidal and proinflammatory peptide stimulating immune cells to produce selected cytokines and NO in NF-ĸB dependent manner. This study aims to identify the receptor which mediates this activity.
Śmiałek-Bartyzel, Justyna +4 more
openaire +3 more sources
TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides [PDF]
Journal of Biological Chemistry, 2006 Bacterial cell walls contain lipoproteins/peptides, which are strong modulators of the innate immune system. Triacylated lipopeptides are assumed to be recognized by TLR2/TLR1-, whereas diacylated lipopeptides use TLR2/TLR6 heteromers for signaling. Following our initial discovery of TLR6-independent diacylated lipopeptides, we could now characterize ...
Buwitt-Beckmann, U. +6 more
openaire +3 more sources
An 192 bp ERV Insertion in the First Intron of TLR6 Acts as an Enhancer to Increase TLR6 and TLR1 Expression [PDF]
, 2020 Abstract BackgroundToll-like receptors (TLRs) play important roles in building innate immune and inducing adaptive immune responses. Associations of the TLR gene polymorphisms with diseases susceptibility, which are the basis of molecular breeding for disease resistant animals, have been reported extensively.
xiaoyan wang +9 more
openaire +4 more sources
TLR6 Modulates First Trimester Trophoblast Responses to Peptidoglycan [PDF]
The Journal of Immunology, 2008 Abstract Intrauterine bacterial infections are a well-established cause of pregnancy complications. One key observation in a number of abnormal pregnancies is that placental apoptosis is significantly elevated. First trimester trophoblast cells are known to express TLR1 and TLR2 and to undergo apoptosis following exposure to Gram ...
Vikki M, Abrahams +8 more
openaire +2 more sources