Results 71 to 80 of about 16,414 (200)

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Koch, Alexander, Hamann, Lutz, Schott, Matthias, Boehm, Olaf, Grotemeyer, Dirk, Kurt, Muhammed, Schwenke, Carsten, Schumann, Ralf R., Bornstein, Stefan R., Zacharowski, Kai   +9 more
core   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

АССОЦИАЦИЯ ПОЛИМОРФИЗМОВ ГЕНОВ TLR2, TLR4 И TLR6 С КОЛОНИЗАЦИЕЙ STREPTOCOCCUS PNEUMONIAE У РАБОТНИКОВ МЕТАЛЛУРГИЧЕСКОГО ПРОИЗВОДСТВА

Медицина в Кузбассе
Работники предприятий черной металлургии подвергаются воздействию промышленных аэрозолей органической и неорганической природы, что может приводить к нарушению механизмов врожденного иммунитета и увеличению частоты респираторных инфекций.
Татьяна Викторовна Бушуева, Елизавета Павловна Артёменко, Наталья Алексеевна Рослая, Юлия Витальевна Грибова, Алла Константиновна Лабзова, Владимир Борисович Гурвич   +5 more
doaj   +1 more source

Sperm activate TLR2/TLR1 heterodimerization to induce a weak proinflammatory response in the bovine uterus

Frontiers in Immunology, 2023
Toll-like receptor 2 (TLR2) signaling pathway is involved in the sperm-triggered uterine inflammatory response at insemination, but its precise mechanism at molecular-level remains unknown.
Alireza Mansouri, Mohamed Samy Yousef, Mohamed Samy Yousef, Rasoul Kowsar, Nonoka Usui, Ihshan Akthar, Akio Miyamoto   +6 more
doaj   +1 more source

RNA expression of TLR10 in normal equine tissues [PDF]

, 2016
Background: Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse.
A Mortazavi, AH Werners, AM Quintana, BS Leise, CM Seabury, CM Wade, D Schneberger, Grazieli Maboni, H Shinkai, J Moreton, JC Roach, JM Senior, Joanna Moreton, JS Chang, K Brown, L Frellstedt, Lauren Alder, M Oosting, MA Laat de, MA Opsal, MD Figueiredo, MH Kogut, MJ Mulla, N Fitzner, NM Astakhova, Rachael E. Tarlinton, RG Govindaraj, Richard D. Emes, S Fleige, S Kwon, SA Bustin, Sabine Tötemeyer, SM Kanzok, T Chuang, T Regan, T Requena, U Hasan, V Hornung, Y Guan, YW Zhang   +39 more
core   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model [PDF]

, 2016
E.K was funded by the British Heart Foundation Grant # FS113028789 and JRW was funded by Arthritis Research-UK Grant ...
Gomez-Garcia, L, Kay, E, Scotland, RS, Whiteford, JR, Woodfin, A   +4 more
core   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, EarlyView.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Genetic variants of innate immune receptors and infections after liver transplantation. [PDF]

, 2017
Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is
Cervera, Carlos, Lozano Soto, Francisco, Moreno Camacho, Ma. Asunción, Navasa, Miquel, Sanclemente, Gemma   +4 more
core   +1 more source