Results 81 to 90 of about 16,414 (200)

Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk [PDF]

JNCI Journal of the National Cancer Institute, 2005
Chronic inflammation plays an important role in several human cancers and may be involved in the etiology of prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross-talk between innate immunity and adaptive immunity.
Jielin, Sun, Fredrik, Wiklund, S Lilly, Zheng, Baoli, Chang, Katarina, Bälter, Liwu, Li, Jan-Erik, Johansson, Ge, Li, Hans-Olov, Adami, Wennuan, Liu, Amy, Tolin, Aubrey R, Turner, Deborah A, Meyers, William B, Isaacs, Jianfeng, Xu, Henrik, Grönberg   +15 more
openaire   +2 more sources

Determination of Genetic Variations of Toll-Like Receptor (TLR) 2, 4, and 6 with Next-Generation Sequencing in Native Cattle Breeds of Anatolia and Holstein Friesian

Diversity, 2016
In recent years, the focus of disease resistance and susceptibility studies in cattle have been on determining patterns in the innate immune response of key proteins, such as Toll-like receptors (TLR).
Nuket Bilgen, Bengi Cinar Kul, Victoria Offord, Dirk Werling, Okan Ertugrul   +4 more
doaj   +1 more source

Haplotype Disequilibrium in the TLR Genes of Czech Red Pied Cattle

Diversity, 2023
Hybrid resequencing of the antibacterial innate immune genes coding for toll-like receptors, namely TLR1, TLR2, TLR4, TLR5, and TLR6, using HiSeq and PacBio technologies of pooled population samples of Czech Simmental (Czech Red) cattle allowed us to ...
Kalifa Samaké, Karel Novák
doaj   +1 more source

Differential effects of cytokines and corticosteroids on Toll-like receptor 2 expression and activity in human airway epithelia [PDF]

, 2009
Background The recognition of microbial molecular patterns via Toll-like receptors (TLRs) is critical for mucosal defenses. Methods Using well-differentiated primary cultures of human airway epithelia, we investigated the effects of exposure of the cells
S Akira, G Soong, T Homma, CJ Hertz, L Guillot, HP Jia, J Tseng, R Adamo, M Ritter, CM Greene, CM Greene, MW Hornef, MT Abreu, T Kaisho, CR Wira, O Levy, K Harju, B Schaub, K Sadeghi, NH Hillman, O Takeuchi, O Takeuchi, PK Singh, MA Hermoso, PH Karp, TE Scheetz, RA Irizarry, RC Gentleman, M Reich, TD Starner, RI Lehrer, AL Humlicek, LJ Manzel, WS Rasband, CL Chin, TH Hassard, S Becker, A Imasato, T Shuto, YM Janssen-Heininger, PP Tak, DC Look, CM Horvath, TD Starner   +43 more
core   +2 more sources

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Association of Toll-like receptor polymorphism and gene expression level with the risk of developing chronic obstructive pulmonary disease (COPD) and its severity

Бюллетень сибирской медицины
Aim. Determine the influence of genetic factors of innate immunity on the risk of development and severity of COPD. Materials and methods. The study included 103 patients diagnosed with chronic obstructive pulmonary disease and 47 conditionally healthy ...
S. A. Salamaikina, V. I. Korchagin, K. O. Mironov, M. A. Karnaushkina   +3 more
doaj   +1 more source

TLRs and Bcl-2 family proteins in neutrophils of oral cavity cancer patients.

Folia Histochemica et Cytobiologica, 2010
Human neutrophils (PMNs), the cells engaged in the early phase of anti-tumor response, express TLR2 and TLR6 that can modulate the Bcl-2 family proteins, regulating the intrinsic apoptotic pathway in these cells.
Marzena Garley, Ewa Jablonska
doaj   +1 more source

Comparative Genomics of Pinna rudis and Pinna nobilis Reveals Conserved and Divergent Features of the Bivalve Defensome

Ecology and Evolution, Volume 16, Issue 3, March 2026.
We present the first high‐quality annotated genome of Pinna rudis and an updated genome assembly for Pinna nobilis, two Mediterranean fan mussel species differentially affected by mass mortality events. Comparative genomic analyses of gene sets associated with the “defensome” show that these genes are largely functionally conserved between the two ...
Stéphane Coupé, Mathieu Foulquié, Maite Vázquez Luis, Elvira Alvarez Perez, Jean‐Marc Prévot, Nardo Vicente, Robert Bunet   +6 more
wiley   +1 more source

Toll-like receptor (TLR) 2 and TLR4 gene expression in canine heart [PDF]

, 2007
Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic.
Blecha, Frank, Linde, Annika, Melgarejo, Tonatiuh   +2 more
core   +2 more sources