Results 201 to 210 of about 38,400 (238)
Some of the next articles are maybe not open access.
Expression of TLR9 within human glioblastoma
Journal of Neuro-Oncology, 2008Immunostimulating oligonucleotides containing CpG motifs (CpG-ODN) have shown promising antitumor activity in preclinical glioma models. CpG motifs are specifically recognized by the Toll-like receptor 9 (TLR9), mainly expressed in plasmacytoid dendritic cells (pDCs) and B cells. Expression of TLR9 within human glioma samples has not been investigated.
Joelle Thillet +2 more
exaly +3 more sources
TLR9-Based Immunotherapy for Allergic Disease
American Journal of Medicine, 2006A significant amount of data generated over the last few years supports the contention that Toll-like receptor (TLR) 9-based immunotherapy is effective in the prevention and treatment of animal models of allergic disorders. We will review here our experience with two distinct therapeutic strategies: TLR9-based immunomodulation and TLR9-based ...
Eyal Raz, Tomoko Hayashi
exaly +3 more sources
Life Sciences, 2022
The innate immune system is a primary protective line in our body. It confers its protection through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs). Toll like receptor 9 (TLR9) is an intracellular TLR, expressed in different immunological and non-immunological cells.
Mona M, Saber +4 more
openaire +2 more sources
The innate immune system is a primary protective line in our body. It confers its protection through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs). Toll like receptor 9 (TLR9) is an intracellular TLR, expressed in different immunological and non-immunological cells.
Mona M, Saber +4 more
openaire +2 more sources
Activation of rabbit TLR9 by different CpG-ODN optimized for mouse and human TLR9
Comparative Immunology, Microbiology and Infectious Diseases, 2012Synthetic CpG-oligodeoxynucleotides (CpG-ODN) are potent adjuvants that accelerate and boost antigen-specific immune responses. Toll-like receptor 9 (TLR9) is the cellular receptor for these CpG-ODN. Previous studies have shown species-specific activation of mouse TLR9 (mTLR9) and human TLR9 (hTLR9) by their optimized CpG-ODN.
Jin, Liu +10 more
openaire +2 more sources
The immunobiology of the TLR9 subfamily
Trends in Immunology, 2004Abstract Members of the Toll-like receptor 9 (TLR9) subfamily are evolutionarily related and sense viral and bacterial infections at the endosomal subcellular compartment. Whereas TLR9 directly recognizes as ligands viral and bacterial CpG-DNA motifs, murine TLR7 and human TLR8 sense viral single stranded RNA motifs.
openaire +2 more sources
TLR9-Mediated Recognition of DNA
2008The mammalian immune system senses pathogens through pattern recognition receptors (PRRs) and responds with activation. The Toll-like receptor (TLR) family that consists of 13 receptors plays a critical role in this process. TLRmediated signaling activates immune cells and leads to an innate immune response with subsequent initiation of an adaptive ...
Thomas, Müller +2 more
openaire +2 more sources
Function and regulation of TLR9
2023Macrophages, dendritic cells and B cells detect bacterial DNA containing unmethylated CpG motifs via Toll-like receptor 9 (TLR9) and respond by producing proinflammatory mediators such as IL-6, IL-12 and TNF, and upregulating cell surface expression of co-stimulatory molecules.
openaire +2 more sources
Nature Reviews Immunology, 2018
TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3.
openaire +2 more sources
TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3.
openaire +2 more sources
TLR9 as a key receptor for the recognition of DNA☆
Advanced Drug Delivery Reviews, 2008Unmethylated DNA with CpG-motifs is recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Macrophages and conventional dendritic cells (cDCs) produce proinflammatory cytokines to B/K-type CpG-DNA, whereas plasmacytoid DCs induce type I interferons to A/D-type CpG-DNA and DNA viruses.
Yutaro, Kumagai +2 more
openaire +2 more sources
DNA Motifs Suppressing TLR9 Responses
Critical Reviews™ in Immunology, 2006Immune cells respond to bacterial DNA containing unmethylated CpG motifs via Toll-like receptor 9 (TLR9). Given the apparent role of TLR9 in development of systemic lupus erythematosus (SLE), there is interest in the development of TLR9 inhibitors. TLR9-mediated responses are reported to be inhibited by a confusing variety of different DNA sequences ...
Trieu, Angela +4 more
openaire +5 more sources