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CpG Oligodeoxyneucleotides as TLR9 Agonists
BioDrugs, 2009Toll-like receptors (TLRs) are part of the innate immune system, and they belong to the pattern recognition receptors (PRR) family. The PRR family is designed to recognize and bind conserved pathogen-associated molecular patterns, which are not generated by the host and are restricted and essential to micro-organisms.
Murad, Yanal M., Clay, Timothy M.
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Bacterial CpG-DNA Licenses TLR9
2002The family of Toll-like receptors (TLRs) plays an important role in the innate immune response to pathogens. TLRs sense pathogen associated molecular patterns (PAMP) and lead to the stimulation of immune cells. In man, so far ten members (TLR1-10) have been reported.
S, Bauer, H, Wagner
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[TLR3c.1377, TLR9-1486, and TLR9 2848 gene polymorphisms and multiple sclerosis].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2011To investigate the relationship between the gene polymorphism of TLR3c.1377,TLR9-1486,and TLR9 2848 and susceptibility to multiple sclerosis(MS)in Han people of south China.A total of 123 unrelated MS patients from South China with a clinical or laboratory definition MS according to 2005 Revisions to the McDonald Criteria were studied.
Xiaobei, Ji +3 more
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Science Signaling, 2016
TLR9 recognizing mitochondrial DNA sustains autophagic flux by functioning as a signaling adaptor protein at lysosomes.
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TLR9 recognizing mitochondrial DNA sustains autophagic flux by functioning as a signaling adaptor protein at lysosomes.
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56 Aacetaminophen Hepatotoxicity Is Dependent On TLR9 and Can Be Reduced By a TLR9 Antagonist
Gastroenterology, 2008Shamail Mahmood +4 more
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TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
EBioMedicine, 2019Kaja Żuwala +2 more
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