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TLR9-Based Immunotherapy for Allergic Disease
American Journal of Medicine, 2006A significant amount of data generated over the last few years supports the contention that Toll-like receptor (TLR) 9-based immunotherapy is effective in the prevention and treatment of animal models of allergic disorders. We will review here our experience with two distinct therapeutic strategies: TLR9-based immunomodulation and TLR9-based ...
Eyal Raz, Tomoko Hayashi
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Life Sciences, 2022
The innate immune system is a primary protective line in our body. It confers its protection through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs). Toll like receptor 9 (TLR9) is an intracellular TLR, expressed in different immunological and non-immunological cells.
Mona M, Saber +4 more
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The innate immune system is a primary protective line in our body. It confers its protection through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs). Toll like receptor 9 (TLR9) is an intracellular TLR, expressed in different immunological and non-immunological cells.
Mona M, Saber +4 more
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Redundant role of TLR9 for anti-Candida host defense [PDF]
Immunobiology, 2008 Contains fulltext : 71201.pdf (Publisher’s version ) (Open Access)The role of Toll-like receptor-9 (TLR9) in the recognition of Candida albicans and anti-Candida host defense was investigated in a murine model of disseminated ...
Bart Jan Kullberg, Mihai Netea
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, 2021 Disclosed are compositions and methods for targeted treatment of cancers, such as TLR9-expressing cancers. In particular, molecules containing a TLR9 targeting ligand, such as a CpG oligodeoxynucleotide, that target lytic peptides to TLR9-expressing ...
LIST ALAN, WEI SHENG, MCLAUGHLIN MARK L
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The immunobiology of the TLR9 subfamily
Trends in Immunology, 2004Abstract Members of the Toll-like receptor 9 (TLR9) subfamily are evolutionarily related and sense viral and bacterial infections at the endosomal subcellular compartment. Whereas TLR9 directly recognizes as ligands viral and bacterial CpG-DNA motifs, murine TLR7 and human TLR8 sense viral single stranded RNA motifs.
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TLR9-Mediated Recognition of DNA
2008The mammalian immune system senses pathogens through pattern recognition receptors (PRRs) and responds with activation. The Toll-like receptor (TLR) family that consists of 13 receptors plays a critical role in this process. TLRmediated signaling activates immune cells and leads to an innate immune response with subsequent initiation of an adaptive ...
Thomas, Müller +2 more
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Nature Reviews Immunology, 2018
TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3.
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TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3.
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Function and regulation of TLR9
2023Macrophages, dendritic cells and B cells detect bacterial DNA containing unmethylated CpG motifs via Toll-like receptor 9 (TLR9) and respond by producing proinflammatory mediators such as IL-6, IL-12 and TNF, and upregulating cell surface expression of co-stimulatory molecules.
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TLR9 as a key receptor for the recognition of DNA☆
Advanced Drug Delivery Reviews, 2008Unmethylated DNA with CpG-motifs is recognized by Toll-like receptor 9 (TLR9) and pleiotropic immune responses are elicited. Macrophages and conventional dendritic cells (cDCs) produce proinflammatory cytokines to B/K-type CpG-DNA, whereas plasmacytoid DCs induce type I interferons to A/D-type CpG-DNA and DNA viruses.
Yutaro, Kumagai +2 more
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CpG Oligodeoxyneucleotides as TLR9 Agonists
BioDrugs, 2009Toll-like receptors (TLRs) are part of the innate immune system, and they belong to the pattern recognition receptors (PRR) family. The PRR family is designed to recognize and bind conserved pathogen-associated molecular patterns, which are not generated by the host and are restricted and essential to micro-organisms.
Murad, Yanal M., Clay, Timothy M.
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