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A decoy oligodeoxynucleotide favors the differentiation of CpG ODN-induced B cells into IL-10-producing Breg-like cells over plasma cells by restoring IRF4/IRF8 imbalance. [PDF]
Cell Mol Life SciLu F +7 more
europepmc +1 more source
Mangiferin inhibits cGAS-STING pathway-related inflammation via Nrf2 activation to protect against sepsis-induced heart injury. [PDF]
Chin MedSong J +6 more
europepmc +1 more source
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Nature Reviews Immunology, 2018
TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3.
Kirsty Minton
exaly +3 more sources
TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3.
Kirsty Minton
exaly +3 more sources
Life Sciences, 2022
The innate immune system is a primary protective line in our body. It confers its protection through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs). Toll like receptor 9 (TLR9) is an intracellular TLR, expressed in different immunological and non-immunological cells.
Mona M, Saber +4 more
openaire +2 more sources
The innate immune system is a primary protective line in our body. It confers its protection through different pattern recognition receptors (PRRs), especially toll like receptors (TLRs). Toll like receptor 9 (TLR9) is an intracellular TLR, expressed in different immunological and non-immunological cells.
Mona M, Saber +4 more
openaire +2 more sources
DNA Motifs Suppressing TLR9 Responses
Critical Reviews™ in Immunology, 2006Immune cells respond to bacterial DNA containing unmethylated CpG motifs via Toll-like receptor 9 (TLR9). Given the apparent role of TLR9 in development of systemic lupus erythematosus (SLE), there is interest in the development of TLR9 inhibitors. TLR9-mediated responses are reported to be inhibited by a confusing variety of different DNA sequences ...
Trieu, Angela +4 more
openaire +3 more sources
TLR9-Mediated Recognition of DNA
2008The mammalian immune system senses pathogens through pattern recognition receptors (PRRs) and responds with activation. The Toll-like receptor (TLR) family that consists of 13 receptors plays a critical role in this process. TLRmediated signaling activates immune cells and leads to an innate immune response with subsequent initiation of an adaptive ...
Thomas, Müller +2 more
openaire +2 more sources
International Reviews of Immunology, 2006
Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids. TLR9 is expressed in intracellular compartments where it responds specifically to pathogen DNA. Several factors contribute to the ability of TLR9 to discriminate between self and foreign DNA.
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Toll-like receptor 9 (TLR9) is specialized for the recognition of pathogenic nucleic acids. TLR9 is expressed in intracellular compartments where it responds specifically to pathogen DNA. Several factors contribute to the ability of TLR9 to discriminate between self and foreign DNA.
openaire +2 more sources
Bacterial CpG-DNA Licenses TLR9
2002The family of Toll-like receptors (TLRs) plays an important role in the innate immune response to pathogens. TLRs sense pathogen associated molecular patterns (PAMP) and lead to the stimulation of immune cells. In man, so far ten members (TLR1-10) have been reported.
S, Bauer, H, Wagner
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Expression of TLR9 within human glioblastoma
Journal of Neuro-Oncology, 2008Immunostimulating oligonucleotides containing CpG motifs (CpG-ODN) have shown promising antitumor activity in preclinical glioma models. CpG motifs are specifically recognized by the Toll-like receptor 9 (TLR9), mainly expressed in plasmacytoid dendritic cells (pDCs) and B cells. Expression of TLR9 within human glioma samples has not been investigated.
Yuxia, Meng +6 more
openaire +2 more sources