Results 91 to 100 of about 25,778 (287)

Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis

Mediators of Inflammation, 2020
Trimethylamine N-oxide (TMAO) is a biologically active molecule generated by the gut microbiota. Accumulating evidences have indicated a close association between high plasma TMAO levels and the risk of developing atherosclerosis (AS). AS is considered a
Yarong Liu, Min Dai
doaj   +1 more source

The associations between TMAO-related metabolites and blood lipids and the potential impact of rosuvastatin therapy

Lipids in Health and Disease, 2022
Background Trimethylamine N-oxide (TMAO)-related metabolites are associated with the pathogenesis of atherosclerotic cardiovascular disease (ASCVD) and are known to disrupt lipid metabolism.
Xiaowei Xiong, Jian Zhou, Qiang Fu, Xiaowei Xu, Shaobin Wei, Shenghua Yang, Buxing Chen   +6 more
doaj   +1 more source

Sequence‐Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides

ChemistryEurope, EarlyView.
Two oppositely charged intrinsically disordered peptides (IDPs) coassemble into heterotypic nanofibers. Homochiral mixtures (L/L IDPs) form homogeneous, aligned bundles with the more positive IDP. Heterochiral mixtures (L/D IDPs) yield heterogeneous, twisted bundles as positive‐IDP content increases.
Yuchen Qiao, Matthew Chu, Grace Wu, Zhiyu Liu, Bing Xu   +4 more
wiley   +1 more source

Association of TMAO levels with indicators of ulcerative colitis activity [PDF]

Caspian Journal of Internal Medicine
Background: The diagnosis of ulcerative colitis (UC) today is limited to a small number of biomarkers. Trimethylamine-N-oxide (TMAO) is the product of reactions resulting from the degradation of dietary-free choline, phosphatidylcholine, and carnitine ...
Yelena Laryushina, Nadezhda Samoilova-Bedych, Lyudmila Turgunova, Alexander Marchenko, Yermek Turgunov   +4 more
doaj  

Serum Intestinal Metabolites are Raised in Patients with Psoriasis and Metabolic Syndrome

Clinical, Cosmetic and Investigational Dermatology, 2022
Liyun Sun,1,* Xinwei Guo,2,* Yeping Qin,3 Ping Li,4 Chunxia Yu,2 Xuesong Gao,2 Xinran Xie,4 Xuying Xu5 1Dermatology Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of ...
Sun L, Guo X, Qin Y, Li P, Yu C, Gao X, Xie X, Xu X   +7 more
doaj  

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

Simultaneous Measurement of Urinary Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) by Liquid Chromatography–Mass Spectrometry

Molecules, 2020
Trimethylamine (TMA) is a gut microbial metabolite—rendered by the enzymatic cleavage of nutrients containing a TMA moiety in their chemical structure.
Xun Jia, Lucas J. Osborn, Zeneng Wang
doaj   +1 more source