Results 91 to 100 of about 21,015 (212)

Iron cyclopentadienone complexes derived from C2-symmetric bis-propargylic alcohols; preparation and applications to catalysis [PDF]

, 2016
A series of complexes containing the iron-cyclopentadienone structure were prepared by cyclising bis-propargylic alcohols and their derivatives with iron pentacarbonyl.
Clarkson, Guy J., Del Grosso, Alessandro, Hodgkinson, Roy, Wills, Martin   +3 more
core   +1 more source

Measuring the stability of partly folded proteins using TMAO [PDF]

Protein Science, 2003
AbstractStandard methods for measuring free energy of protein unfolding by chemical denaturation require complete folding at low concentrations of denaturant so that a native baseline can be observed. Alternatively, proteins that are completely unfolded in the absence of denaturant can be folded by addition of the osmolyte trimethylamine N‐oxide (TMAO),
Cecilia C, Mello, Doug, Barrick
openaire   +2 more sources

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation

Cell Proliferation, EarlyView.
During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu, Danning Ma, Jia Song, Boon Chin Heng, Ying Huang, Xuehui Zhang, Mingming Xu, Yan Wei, Tai Wei, Jinqi Wei, Xuliang Deng   +10 more
wiley   +1 more source

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

Frontiers in Molecular Neuroscience, 2020
Dysbiosis of gut microbiota is strongly associated with metabolic diseases including diabetes mellitus, obesity, and cardiovascular disease. Recent studies indicate that Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite is implicated in ...
Manoj Govindarajulu, Manoj Govindarajulu, Priyanka D. Pinky, Priyanka D. Pinky, Ian Steinke, Jenna Bloemer, Jenna Bloemer, Sindhu Ramesh, Sindhu Ramesh, Thiruchelvan Kariharan, Robert T. Rella, Subhrajit Bhattacharya, Subhrajit Bhattacharya, Muralikrishnan Dhanasekaran, Muralikrishnan Dhanasekaran, Vishnu Suppiramaniam, Vishnu Suppiramaniam, Rajesh H. Amin, Rajesh H. Amin   +18 more
doaj   +1 more source

Shikimate pathway disruption in yeast induces metabolite self‐assembly into toxic aggregates

The FEBS Journal, EarlyView.
In Saccharomyces cerevisiae, shikimate pathway disruption induces toxic metabolite assemblies. Deleting ARO4 plus phenylalanine (Phe) feeding causes Phenylalanine accumulation, lowers ARO3 activity, and triggers amyloid‐like fibril formation. Deleting ARO3 plus tyrosine (Tyr) feeding leads to Tyrosine buildup and similar fibril assembly.
Hanaa Adsi, Myra Gartner, Claris Simovich, Lihi Gershon, Alexander Brandis, Ehud Gazit, Dana Laor Bar‐Yosef   +6 more
wiley   +1 more source

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly [PDF]

, 2017
Significance: The incidence of cardiovascular events (CVEs) increases with age, representing the main cause of death in an elderly population. Aging is associated with overproduction of reactive oxygen species (ROS), which may affect clotting and ...
Carnevale, Roberto, Loffredo, Lorenzo, Pastori, Daniele, Pignatelli, Pasquale, Violi, Francesco   +4 more
core   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

O2-independent demethylation of trimethylamine N-oxide by Tdm of Methylocella silvestris [PDF]

, 2016
Bacterial trimethylamine N-oxide (TMAO) demethylase, Tdm, carries out an unusual oxygen-independent demethylation reaction, resulting in the formation of dimethylamine and formaldehyde.
Blindauer, Claudia A., Bugg, Tim, Chen, Yin, Ksibe, Amira Z., Schäfer, Hendrik, Zhu, Yijun   +5 more
core   +1 more source

Variation in Microbiome Composition and Faecal Metabolites Are Associated With Differential Susceptibility to DSS‐Induced Colitis

Immunology, Volume 177, Issue 4, Page 766-783, April 2026.
C57BL/6 mice from Charles River Laboratories (CR) have enhanced mucosal immune action relative to C57BL/6 mice from Jackson Laboratories (JAX). CR mice are more susceptible to severe DSS‐induced colitis than JAX mice. Co‐housing transfers colitis susceptibility from CR mice to JAX mice.
Jessica M. Till, Orion D. Brock, Elyza A. Do, Morgan J. Engelhart, Robert W. P. Glowacki, Shaomin Hu, Ansel Hsiao, Ina Nemet, Philip P. Ahern   +8 more
wiley   +1 more source

Trimethylamine-N-oxide (TMAO) as novel potential biomarker of early predictors of metabolic syndrome [PDF]

, 2018
There is a mechanistic link between the gut-derived metabolite trimethylamine-N-oxide (TMAO) and obesity-related diseases, suggesting that the TMAO pathway may also be linked to the pathogenesis of obesity.
Annunziata, Giuseppe, Barrea, Luigi, Colao, Annamaria, de Alteriis, Giulia, Di Somma, Carolina, Laudisio, Daniela, Maisto, Maria, Muscogiuri, Giovanna, Savastano, Silvia, Tenore, Gian Carlo   +9 more
core   +2 more sources