Results 81 to 90 of about 25,778 (287)

Effect of dapagliflozin on ferroptosis through the gut microbiota metabolite TMAO during myocardial ischemia–reperfusion injury in diabetes mellitus rats

Scientific Reports
Dapagliflozin (DAPA) demonstrates promise in the management of diabetic mellitus (DM) and cardiomyopathy. Trimethylamine N-oxide (TMAO) is synthesized by the gut microbiota through the metabolic conversion of choline and phosphatidylcholine.
Lian Wang, Yao Wang, Heng Xu, Wenyuan Li
semanticscholar   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine, EarlyView.
This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous training (MICT) intervention.
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
wiley   +1 more source

Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease [Corrigendum]

Clinical Interventions in Aging, 2021
He W, Luo Y, Liu JP, et al. Clin Interv Aging. 2020;15:1809– 1820. The authors have advised affiliation 2 on page 1809 is incorrect, the text “Peking Union Medical College” should read “Graduate School of Peking Union ...
He W, Luo Y, Liu JP, Sun N, Guo D, Cui LL, Zheng PP, Yao SM, Yang JF, Wang H   +9 more
doaj  

Effects of acute administration of trimethylamine N-oxide on endothelial function: a translational study

Scientific Reports, 2022
Elevated circulating levels of nutrient-derived trimethylamine N-oxide (TMAO) have been associated with the onset and progression of cardiovascular disease by promoting athero-thrombosis.
Anne Jomard, Luca Liberale, Petia Doytcheva, Martin F. Reiner, Daniel Müller, Michele Visentin, Marco Bueter, Thomas F. Lüscher, Roberto Vettor, Thomas A. Lutz, Giovanni G. Camici, Elena Osto   +11 more
doaj   +1 more source

Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]

, 2016
© The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ, Crossey, MM, Fye, HK, Gomez-Romero, M, Holmes, E, Kim, JU, Njie, R, Shariff, MI, Taylor-Robinson, SD   +8 more
core   +1 more source

Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in Regulating TMAO-Mediated Inflammatory Response

Medical Science Monitor
Background Sishen Pills (SSPs) are commonly used to treat diarrhea with kidney-yang deficiency syndrome. Trimethylamine-N-oxide (TMAO) is produced through the metabolism of gut microbiota and can participate in diarrhea in kidney-yang deficiency syndrome
Shiqin Xie, Leyao Fang, Na Deng, Junxi Shen, Zhoujin Tan, Xinxin Peng   +5 more
semanticscholar   +1 more source

Trimethylamine N-Oxide (TMAO) Impairs Purinergic Induced Intracellular Calcium Increase and Nitric Oxide Release in Endothelial Cells

International Journal of Molecular Sciences, 2022
Trimethylamine N-oxide (TMAO) is a diet derived compound directly introduced through foodstuff, or endogenously synthesized from its precursors, primarily choline, L-carnitine, and ergothioneine.
G. Querio, S. Antoniotti, F. Geddo, R. Levi, M. P. Gallo   +4 more
semanticscholar   +1 more source

The Role of Microbiota in Cardiovascular Risk: Focus on Trimethylamine Oxide [PDF]

, 2019
The extensive collection of bacteria cohabiting within the host collaborates with human functions and metabolisms in both health and disease. The fine equilibrium of commensals is tightly controlled and an imbalance (“dysbiosis”) in the gut microbiota ...
Al-Rubaye, H, Kaski, J-C, Perfetti, G
core   +1 more source

Microbiome-Derived Trimethylamine N-Oxide (TMAO) as a Multifaceted Biomarker in Cardiovascular Disease: Challenges and Opportunities

International Journal of Molecular Sciences
Biomarkers play a crucial role in various stages of disease management, including screening, diagnosis, prediction, prognosis, treatment, and safety monitoring.
K. Jaworska, Wojciech Kopacz, Mateusz Koper, M. Ufnal   +3 more
semanticscholar   +1 more source

The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway

International Journal of Molecular Sciences, 2021
Trimethylamine N-oxide (TMAO), a product of gut microbiota metabolism, has previously been shown to be implicated in chronic kidney disease. A high TMAO-containing diet has been found to cause tubulointerstitial renal fibrosis in mice.
Stefania Kapetanaki, A. K. Kumawat, Katarina S. Persson, I. Demirel   +3 more
semanticscholar   +1 more source