Results 181 to 190 of about 29,410 (210)
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Cancer Research, 2017
Abstract Background: Although antibody targeting of the HER2 oncogene represents an outstanding clinical treatment and a success story showing direct cancer killing with antibodies, many oncogenes are intracellular and are not expressed broadly, whether on a single or multiple tumor types.
Heather Torrey +12 more
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Abstract Background: Although antibody targeting of the HER2 oncogene represents an outstanding clinical treatment and a success story showing direct cancer killing with antibodies, many oncogenes are intracellular and are not expressed broadly, whether on a single or multiple tumor types.
Heather Torrey +12 more
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TNFR2 – Target for Therapeutics Against Neurodegenerative Diseases?
2010Tumor necrosis factor α (TNFα) is a proinflammatory cytokine which acts via its two receptors TNFR1 and TNFR2. It is involved in many cell types in various cellular functions of cell growth, differentiation, and cellular apoptosis. Whereas soluble TNF has the highest affinity for TNFR1 and is therefore its main activator, the membrane standing ...
Nijholt, I.M. +3 more
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TNFR2: A Novel Target for Cancer Immunotherapy
Trends in Molecular Medicine, 2017Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but exhibit variable efficacy and relapse and can induce autoimmunity. Tumor necrosis factor (TNF) receptor 2 (TNFR2) is a signaling molecule found on the surface of a subset of potent regulatory T cells (Tregs) that can activate the proliferation of these cells through nuclear ...
Éva S, Vanamee, Denise L, Faustman
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Endothelial-Specific Transgenesis of TNFR2 Promotes Adaptive Arteriogenesis and Angiogenesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2010 Objective— We have previously shown that the tumor necrosis factor receptor 2 (TNFR2) protein is highly upregulated in vascular endothelium in response to ischemia, and a global deletion of TNFR2 in mice blunts ischemia-induced arteriogenesis and angiogenesis.
Yan Luo, Yun He, Dennis Jones
exaly +3 more sources
TNFR2 signalling in inflammatory diseases
Best Practice & Research Clinical RheumatologyTNF signals via two receptors, TNFR1 and TNFR2, which play contrasting roles in immunity. Most of the pro-inflammatory effects of TNF are mediated by TNFR1, whereas TNFR2 is mainly involved in immune homeostasis and tissue healing, but also contributes to tumour progression.
Richard O. Williams +4 more
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Biochemical and Biophysical Research Communications
Regulatory T cells (Tregs) are lymphocytes that play a central role in peripheral immune tolerance. Tregs are promising targets for the prevention and suppression of autoimmune diseases, allergies, and graft-versus-host disease, and treatments aimed at regulating their functions are being developed.
Masaki Inoue +7 more
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Regulatory T cells (Tregs) are lymphocytes that play a central role in peripheral immune tolerance. Tregs are promising targets for the prevention and suppression of autoimmune diseases, allergies, and graft-versus-host disease, and treatments aimed at regulating their functions are being developed.
Masaki Inoue +7 more
openaire +2 more sources
Locking TNFR2 to kill ovarian cancer
Science, 2017Cancer Immunotherapy The TNF (tumor necrosis factor) ligand family promotes tumor growth and progression. Torrey et al. developed an antibody that locks TNFR2, a TNF receptor found on immunosuppressive regulatory T cells and some tumor cells, in an inactive state (see the Focus by Chen and Oppenheim).
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Cancer Research, 2021
Abstract Tumor necrosis factor receptor-2 (TNFR2) is a TNF receptor superfamily member which, unlike the well-characterized TNFR1, has been reported to have restricted expression in the immune system especially on suppressive regulatory T cell (Treg).
Xiaofeng Zhao +8 more
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Abstract Tumor necrosis factor receptor-2 (TNFR2) is a TNF receptor superfamily member which, unlike the well-characterized TNFR1, has been reported to have restricted expression in the immune system especially on suppressive regulatory T cell (Treg).
Xiaofeng Zhao +8 more
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Journal of Clinical Oncology, 2017
106 Background: A major barrier to cancer immunotherapy is lack of selective inhibitors of the regulatory T cells (Tregs) of the cancer microenvironment and methods to directly kill tumors through novel surface oncogenes. Tumor necrosis factor receptor 2 (TNFR2) is a target protein with restricted expression on the most potent Tregs of the tumor ...
Denise L. Faustman +11 more
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106 Background: A major barrier to cancer immunotherapy is lack of selective inhibitors of the regulatory T cells (Tregs) of the cancer microenvironment and methods to directly kill tumors through novel surface oncogenes. Tumor necrosis factor receptor 2 (TNFR2) is a target protein with restricted expression on the most potent Tregs of the tumor ...
Denise L. Faustman +11 more
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Optimizing TNFR2 antagonism for immunotherapy with tumor microenvironment specificity
Journal of Leukocyte Biology, 2020Abstract Most approved cancer immunotherapies lack T-regulatory (Treg) or tumor specificity. TNF receptor 2 (TNFR2) antibody antagonism is emerging as an attractive immunotherapy due to its tumor microenvironment (TME) specificity. Here we show that the human TNFR2 receptor is overexpressed on both human tumor cells and on human tumor ...
Michael Yang +9 more
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