Results 191 to 200 of about 29,410 (210)
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Dissecting TNFR2 signaling in arteriogenesis and angiogenesis
The FASEB Journal, 2007We have previously shown that TNF via TNFR2 elicits unique Etk‐dependent angiogenic signaling pathways in vascular endothelial cells (EC). Here we use TNFR2‐KO mice to define the roles of TNFR2 in vivo in several arteriogenesis/angiogenesis models Including ischemic hindlimb, inflammatory sponge, cornea and ear angiogenesis models.
Yun He, Dianhong Luo, Wang Min
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Neuro-Oncology
Abstract Checkpoint inhibitors have been successful in various tumors. However, these treatments have failed in glioblastoma. Approaches harnessing the immune response are hindered by multiple factors, including T cell exhaustion. TOX is particularly important for the transcriptional and epigenetic reprogramming of exhausted T cells ...
Alexandra Hoyt-Miggelbrink +13 more
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Abstract Checkpoint inhibitors have been successful in various tumors. However, these treatments have failed in glioblastoma. Approaches harnessing the immune response are hindered by multiple factors, including T cell exhaustion. TOX is particularly important for the transcriptional and epigenetic reprogramming of exhausted T cells ...
Alexandra Hoyt-Miggelbrink +13 more
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TNFR2 signaling modulates immunity after allogeneic hematopoietic cell transplantation
Cytokine & Growth Factor Reviews, 2019Tumor necrosis factor-α (TNF-α) signaling through TNF receptor 2 (TNFR2) plays a complex immune regulatory role in allogeneic hematopoietic cell transplantation (HCT). TNF-α is rapidly released in the circulation after the conditioning regimen with chemotherapy and/or radiotherapy.
Antonella, Mancusi +4 more
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Generation of a sensitive TNFR2-specific murine assays system.
Die Pharmazie, 2016Tumor necrosis factor (TNF)/TNF receptors (TNFR1/TNFR2) are considered to be potential drug targets to treat refractory diseases, including autoimmune diseases and malignant tumors. However, their specific functions, especially in the case of TNFR2, are poorly understood.
Ando , D. +8 more
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Cancer Immunology Research
Abstract Checkpoint inhibitors have been very successful in various tumors, including melanoma and lung cancer. However, these treatments have failed in other tumors, including pancreatic cancer and glioblastoma. Approaches harnessing the immune response are hindered by multiple factors, including T cell exhaustion. Exhausted T cells are
Alexandra Hoyt-Miggelbrink +12 more
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Abstract Checkpoint inhibitors have been very successful in various tumors, including melanoma and lung cancer. However, these treatments have failed in other tumors, including pancreatic cancer and glioblastoma. Approaches harnessing the immune response are hindered by multiple factors, including T cell exhaustion. Exhausted T cells are
Alexandra Hoyt-Miggelbrink +12 more
openaire +1 more source
Dissecting TNF-TNFR1/TNFR2 signaling pathways in vasculature
2010Inflammation is a process essential for host defense and tissue repair. However, excessive inflammation (excessive and/or prolonged production and effects of pro-inflammatory cytokines) may cause pathogenic changes leading to vascular diseases such as rheumatoid arthritis and atherosclerosis.
Wang Min, Ting Wan, Yan Luo
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The role of TNFR2 in experimentally induced glomerulonephritis
2012TNF is an important cytokine and acts as mediator of inflammatory tissue damage which is caused by immunologically mediated processes. TNF provides its effects via two signalling pathways using its two receptors, TNFR1 and TNFR2. In 2005 Vielhauer et al.
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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Cellular and Molecular Immunology, 2023Alaa Ali, Lisheng Wang, Subash Sad
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TNF plays a crucial role in inflammation by signaling via T cell TNFR2
Proceedings of the National Academy of Sciences of the United States of America, 2021Yu Fan, Jonathan D Ashwell
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Tumor Necrosis Factor Receptor 2 (TNFR2): An Emerging Target in Cancer Therapy
Cancers, 2022Juliane Medler, Harald Wajant
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