Results 51 to 60 of about 393,653 (192)

Chicken Toll-like Receptor 3 Recognizes Its Cognate Ligand When Ectopically Expressed in Human Cells [PDF]

, 2007
Recognition of pathogens by toll-like receptors (TLRs) causes activation of signaling cascades that trigger cytokine secretion and, ultimately, innate immunity.
Bauer, Stefan, Kaspers, Bernd, Kothlow, Sonja, Lavric, Miha, Ohnemus, Annette, Schneider, Kirsten, Schwarz, Heike, Staeheli, Peter   +7 more
core   +1 more source

Toll-like receptors as adjuvant receptors

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2002
The mammalian Toll-like receptors (TLRs) are expressed on macrophages and dendritic cells, which are primarily involved in innate immunity. At present, ligands for several of the TLRs, such as TLR2, TLR3, TLR4, TLR5, TLR6, and TLR9, have been identified.
Kaisho, Tsuneyasu, Akira, Shizuo
openaire   +2 more sources

K63-Linked Polyubiquitination on TRAF6 Regulates LPS-Mediated MAPK Activation, Cytokine Production, and Bacterial Clearance in Toll-Like Receptor 7/8 Primed Murine Macrophages

Frontiers in Immunology, 2018
Post viral infection bacterial pneumonia is a major cause of morbidity and mortality associated with both seasonal and pandemic influenza virus illness.
Jaya Talreja, Lobelia Samavati, Lobelia Samavati   +2 more
doaj   +1 more source

Structure-activity relationship in monosaccharide-based Toll-like receptor 4 (TLR4) antagonists [PDF]

, 2018
The structure-activity relationship was investigated in a series of synthetic TLR4 antagonists formed by a glucosamine core linked to two phosphate esters and two linear carbon chains.
Airoldi, Cristina, Beyaert, Rudi, Billod, Jean-Marc, Braun, Harald, Calabrese, Valentina, Ciaramelli, Carlotta, Facchini, Fabio A, Forcella, Matilde, Fusi, Paola, Jerala, Roman, Lapenta, Fabio, Martin-Santamaria, Sonsoles, Minotti, Alberto, Palmer, Charys, Peri, Francesco, Pirianov, Grisha, Rapisarda, Silvia, Schromm, Andra B, Zaffaroni, Lenny   +18 more
core   +5 more sources

Drift, not selection, shapes toll-like receptor variation among oceanic island populations [PDF]

, 2015
Understanding the relative role of different evolutionary forces in shaping the level and distribution of functional genetic diversity among natural populations is a key issue in evolutionary and conservation biology.
Acevedo-Whitehouse, Aguilar, Akira, Alcaide, Areal, Basu, Belvin, Betrán, Bollmer, Cabe, Chen, Cramp, Downing, Ekblom, England, Excoffier, Fornůsková, Frankham, Frankham, Garza, Gautschi, Girard, Goslee, Grueber, Grueber, Grueber, Grueber, Hall, Hartl, Hartmann, Hedrick, Hudson, Hughes, Illera, Jensen, Jiggins, Kalinowski, Keestra, Klein, Kryazhimskiy, Librado, Manly, Mikami, Miller, Misch, Murrell, Murrell, Nakajima, Ohta, Oliver, Outlaw, Piertney, Poltorak, Pond, Pond, Quéméré, R Development Core Team, Raymond, Richardson, Roach, Schröder, Sommer, Spurgin, Spurgin, Spurgin, Spurgin, Stephens, Sutton, Takeuchi, Tamura, Teacher, Trowsdale, Tschirren, Tschirren, Turner, Voelker, Winternitz, Wlasiuk, Yoneyama   +78 more
core   +2 more sources

Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.

PLoS ONE, 2015
AimCardiac inflammation is important in the pathogenesis of heart failure. However, the consequence of systemic inflammation on concomitant established heart failure, and in particular diastolic heart failure, is less explored.
Yangchen Dhondup, Ivar Sjaastad, Helge Scott, Øystein Sandanger, Lili Zhang, Solveig Bjærum Haugstad, Jan Magnus Aronsen, Trine Ranheim, Sigve Dhondup Holmen, Katrine Alfsnes, Muhammad Shakil Ahmed, Håvard Attramadal, Lars Gullestad, Pål Aukrust, Geir Christensen, Arne Yndestad, Leif Erik Vinge   +16 more
doaj   +1 more source

Neonatal innate immunity and Toll-like receptor [PDF]

Korean Journal of Pediatrics, 2010
The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity.
Hye Sun Yoon
doaj   +1 more source

KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]

, 2009
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny, K K Reichard, K Sotlar, M K Foucar, S A McClintock-Treep   +4 more
core   +1 more source

Toll-Like Receptor Evolution: Does Temperature Matter?

Frontiers in Immunology, 2022
Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs).
Cármen Sousa, Stefan A. Fernandes, João C. R. Cardoso, Ying Wang, Wanying Zhai, Pedro M. Guerreiro, Liangbiao Chen, Adelino V. M. Canário, Adelino V. M. Canário, Deborah M. Power, Deborah M. Power   +10 more
doaj   +1 more source

Molecular alterations of the TLR4-signaling cascade in canine epilepsy

BMC Veterinary Research, 2020
Background Cumulating evidence from rodent models points to a pathophysiological role of inflammatory signaling in the epileptic brain with Toll-like receptor-4 signaling acting as one key factor.
Eva-Lotta von Rüden, Fabio Gualtieri, Katharina Schönhoff, Maria Reiber, Fabio Wolf, Wolfgang Baumgärtner, Florian Hansmann, Andrea Tipold, Heidrun Potschka   +8 more
doaj   +1 more source