Results 111 to 120 of about 34,084,722 (297)

Toll-like receptor (TLR) expression distribution (%).

, 2019
Toll-like receptor (TLR) expression distribution (%).
Harri Mustonen (641410), Hanna Seppänen (751179), Mira Lanki (6990023), Jaana Hagström (476954), Caj Haglund (476956)   +4 more
core   +1 more source

Sustained Toll-like receptor 9 activation promotes systemic and cardiac inflammation, and aggravates diastolic heart failure in SERCA2a KO mice [PDF]

, 2015
Aim Cardiac inflammation is important in the pathogenesis of heart failure. However, the consequence of systemic inflammation on concomitant established heart failure, and in particular diastolic heart failure, is less explored.
Sigve Dhondup Holmen (812740), Ahmed, Muhammad Shakil, Aronsen, Jan Magnus, Lili Zhang, Muhammad Shakil Ahmed (812741), Leif Erik Vinge (329788), Pål Aukrust (151370), Zhang, Lili, Øystein Sandanger (329789), Håvard Attramadal (224421), Helge Scott, Håvard Attramadal, Attramadal, Håvard, Arne Yndestad (224387), Sigve Dhondup Holmen, Holmen, Sigve, Sandanger, Øystein, Ivar Sjaastad, Lars Gullestad (224437), Pål Aukrust, Christensen, Geir Arve, Ivar Sjaastad (162165), Lili Zhang (120447), Muhammad Shakil Ahmed, Geir Christensen (162197), Haugstad, Solveig Bjærum, Dhondup, Yangchen, Yangchen Dhondup, Scott, Helge, Lars Gullestad, Yndestad, Arne, Gullestad, Lars, Sjaastad, Ivar, Yangchen Dhondup (812738), Helge Scott (4898), Trine Ranheim, Arne Yndestad, Solveig Bjærum Haugstad, Katrine Alfsnes (616207), Alfsnes, Katrine, Solveig Bjærum Haugstad (812739), Trine Ranheim (151364), Geir Christensen, Jan Magnus Aronsen, Katrine Alfsnes, Leif Erik Vinge, Vinge, Leif Erik, Jan Magnus Aronsen (347485), Ranheim, Trine, Aukrust, Pål, Øystein Sandanger   +50 more
core   +1 more source

Determinants of innate immune responses to mycobacteria [PDF]

, 2012
Includes bibliographical references.Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers.
Shey, Muki Shehu
core   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

The role of toll-like receptors in the adrenal gland [PDF]

, 2010
Sepsis is caused by infection and often followed by an overwhelming inflammatory response. This can lead to shock, organ failure and even death. Each year approximately 60,000 people die in Germany due to sepsis.
Tran, Thi Hoai Nguyen
core  

Cell membrane-bound toll-like receptor-1/2/4/6 monomers and -2 heterodimer inhibit enterovirus 71 replication by activating the antiviral innate response. [PDF]

Front Immunol, 2023
Sun PP, Li D, Su M, Ren Q, Guo WP, Wang JL, Du LY, Xie GC.   +7 more
europepmc   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Innate immune activation in experimental autoimmune myocarditis [PDF]

, 2007
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and frequently results from postinfectious autoimmunity. Its pathophysiology is modeled by experimental autoimmune myocarditis (EAM), a CD4+ T-cell mediated murine model of ...
Marty, René Roger
core   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages [PDF]

, 2009
Background Toll-like receptors (TLRs) are present on monocytes and alveolar macrophages that form the first line of defense against inhaled particles.
Esmaeil Mortaz, Nijkamp, Frans P, Caldenhoven Eric, Caldenhoven, Eric, Kraneveld, Aletta D, Gert Folkerts, Sarir Hadi, Folkerts Gert, Nijkamp Frans P, Khalil Karimi, Kraneveld Aletta D, Karimi Khalil, Sarir, Hadi, Mortaz Esmaeil, Karimi, Khalil, Rahman Irfan, Folkerts, Gert, Frans P Nijkamp, Rahman, Irfan, Irfan Rahman, Eric Caldenhoven, Aletta D Kraneveld, Mortaz, Esmaeil, Hadi Sarir   +23 more
core   +1 more source