Results 121 to 130 of about 34,084,722 (297)

The toll-like receptor 1 variant S248N influences placental malaria

Infection, Genetics and Evolution, 2010
In malaria-endemic regions, Plasmodium falciparum infection in pregnancy is a predominant cause of maternal and infant morbidity and mortality. Primiparae are relatively immune-naïve and particularly prone. Innate immune recognition of P. falciparum is partly mediated by Toll-like receptors (TLRs), and single nucleotide polymorphisms (SNPs) of TLR-4 ...
Lutz, Hamann, George, Bedu-Addo, Teunis A, Eggelte, Ralf R, Schumann, Frank P, Mockenhaupt   +4 more
openaire   +2 more sources

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells [PDF]

, 2011
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117.
Bernhard F. Gibbs, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Vadim V. Sumbayev, Inna M Yasinska, Abraham E. Oniku, Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Abraham E Oniku, Inna M. Yasinska   +11 more
core   +2 more sources

Single Immunoglobulin Interleukin1-Related Receptor-TWIST1 Axis Regulates Barrier Function in Neonatal IntestineSummaryWhat You Need to Know

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: The genetic basis of impaired intestinal barrier function in preterm infants is poorly understood. Variants in single immunoglobulin interleukin1-related receptor, a negative regulator of Toll-like receptor signaling, have been ...
Aparna Venkatraman, Wei Yu, Heather L. Menden, Sherry M. Mabry, Joshua L. Wheatley, Shahid Umar, Susana Chavez-Bueno, Venkatesh Sampath   +7 more
doaj   +1 more source

Toll-like receptor-1, -2, and -6 genotypes in relation to salivary human beta-defensin-1, -2, -3 and human neutrophilic peptide-1. [PDF]

J Clin Periodontol, 2022
Gürsoy M, Könönen E, He Q, Liukkonen A, Huumonen S, Gürsoy UK.   +5 more
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll‐like receptor 2 and plasminogen activator inhibitor‐1

Journal of Extracellular Vesicles
Plasminogen activator inhibitor‐1 (PAI‐1) is associated with nonalcoholic fatty liver disease (NAFLD) by lipid accumulation in the liver. In this study, we showed that extracellular vesicles (EVs) from the periodontal pathogens Filifactor alocis and ...
Hyun Young Kim, Younggap Lim, Ji Sun Jang, Yeon Kyeong Ko, Youngnim Choi, Hong‐Hee Kim, Bong‐Kyu Choi   +6 more
doaj   +1 more source

Pmorf0222, a Virulence Factor in Pasteurella multocida, Activates Nuclear Factor Kappa B and Mitogen-Activated Protein Kinase via Toll-Like Receptor 1/2. [PDF]

Infect Immun, 2023
Xu T, Zheng Y, Liu B, Kou M, Jiang Q, Liu J, Kang H, Yang M, Guo D, Qu L.   +9 more
europepmc   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

TLR-9 Expression in Human Bronchial Epithelial Cells induced with Lipopolysaccharide [PDF]

, 2010
The study conducted here was to investigate the gene and protein expression of Toll like receptor 9 when human bronchial epithelial cells were induced by lipopolysaccharide.
Sangeetha Dharmalingam, Shanmuga Saravanabhavan   +1 more
core