Toll like receptors agonists-based nanomedicines as veterinary immunotherapies
Precision Nanomedicine, 2020 Many infections affecting animals enter across mucosa, needing of secretory immunity to reject the disease; protection against some pathogens must be early, fast, and specifically elicited, while from others must be wide enough to fight against ...
Federico L Parra +2 more
doaj +1 more source
Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]
, 2016 Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core +4 more sources
Intracellular Toll-like Receptors [PDF]
Immunity, 2010 Foreign nucleic acids, the signature of invading viruses and certain bacteria, are sensed intracellularly. The nucleic acid-specific Toll-like receptors (TLRs) detect and signal within endolysosomal compartments, triggering the induction of cytokines essential for the innate immune response.
Bruce Beutler, Amanda L. Blasius
openaire +3 more sources
Toll-Like Receptors Gene Polymorphisms in Autoimmune Disease
Frontiers in Immunology, 2021 Toll-like receptors (TLRs) are important initiators of the immune response, both innate and acquired. Evidence suggests that gene polymorphisms within TLRs cause malfunctions of certain key TLR-related signaling pathways, which subsequently increases the
Yingchi Zhang +4 more
semanticscholar +1 more source
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]
, 2005 Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Bartlett, Nathan W +8 more
core +2 more sources
Toll-like Receptors in Viral Encephalitis
Viruses, 2021 Viral encephalitis is a rare but serious syndrome. In addition to DNA-encoded herpes viruses, such as herpes simplex virus and varicella zoster virus, RNA-encoded viruses from the families of Flaviviridae, Rhabdoviridae and Paramyxoviridae are important ...
Olivia Luise Gern +6 more
doaj +1 more source
Transcriptome Modifications in Porcine Adipocytes via Toll-Like Receptors Activation [PDF]
, 2019 Adipocytes are the most important cell type in adipose tissue playing key roles in immunometabolism. We previously reported that nine members of the Toll-like receptor (TLR) family are expressed in an originally established porcine intramuscular pre ...
Albarracín, Leonardo Miguel +13 more
core +1 more source
Emerging role of endosomal toll-like receptors in rheumatoid arthritis [PDF]
, 2014 Toll-like receptors (TLRs) and their downstream signaling pathways have been comprehensively characterized in innate immunity. In addition to this function, these receptors have also been suggested to be involved in the pathogenesis of many autoimmune ...
Chamberlain, Giselle +2 more
core +2 more sources
Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses [PDF]
, 2015 The genesis of severe fatigue and disability in people following acute pathogen invasion involves the activation of Toll-like receptors followed by the upregulation of proinflammatory cytokines and the activation of microglia and astrocytes.
Berk, Michael +3 more
core +2 more sources
Identification of CNS Injury-Related microRNAs as Novel Toll-Like Receptor 7/8 Signaling Activators by Small RNA Sequencing [PDF]
, 2020 Toll-like receptors (TLRs) belong to pattern recognition receptors, which respond to danger signals such as pathogen-associated molecular patterns or damage-associated molecular patterns.
Buonfiglioli, Alice +7 more
core +1 more source