Results 51 to 60 of about 608,641 (362)

Toll-like Receptors and the Eye [PDF]

Investigative Opthalmology & Visual Science, 2006
The immune response to microbial pathogens relies on both innate and adaptive components.1 The innate or immediate response is mediated in large measure by leukocytes of the blood, such as neutrophils (PMNs) and macrophages, cells that phagocytose and kill the pathogens and that concurrently coordinate additional host responses by synthesis of a wide ...
Linda D. Hazlett, Fushin X Yu
openaire   +3 more sources

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
core   +2 more sources

Toll-like receptors and atherosclerosis [PDF]

Medicinski Glasnik, 2009
Toll like receptors (TLR) are receptors with major role in activationof immune system by regulating production of chemokinesand cytokines, which makes them important in different types ofinflammatory reactions- bacterial, viral, parasitic, acute ...
Jerko Barbić, Snježana Džijan, Edo Džumhur, Tamara Alkhamis, Andrea Džumhur   +4 more
doaj  

Toll-Like Receptors and Myocardial Inflammation

International Journal of Inflammation, 2011
Toll-like receptors (TLRs) are a member of the innate immune system. TLRs detect invading pathogens through the pathogen-associated molecular patterns (PAMPs) recognition and play an essential role in the host defense.
Yan Feng, Wei Chao
doaj   +1 more source

Filarial Lymphedema Is Characterized by Antigen- Specific Th1 and Th17 Proinflammatory Responses and a Lack of Regulatory T Cells [PDF]

, 2009
Background: Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. Methods and Findings: To elucidate the role of CD4+ T cell subsets in the
A Saint André, AC Vickery, AG Hise, Angelo B. Lipira, AY Debrah, C. Karthik, CT Weaver, D Tracey, DO Freedman, DO Freedman, DO Freedman, FK Nelson, G Dreyer, Inohara, J Figueredo-Silva, J MacMicking, JS Stumhofer, K Takeda, K Wing, LI Rutitzky, LI Rutitzky, M Gavin, M Numasaki, MD Taylor, MJ McGeachy, MJ Taylor, MJ Taylor, MO Li, N Inohara, N. Pavan Kumar, NW Brattig, P Blanco, P Esterre, RB Lal, RB Lal, Ricardo Toshio Fujiwara, RT Semnani, S Babu, S Babu, S Babu, S Babu, Sajid Q. Bhat, Sanath Kumar, Subash Babu, TB Nutman, TD Kanneganti, Thomas B. Nutman, V. Kumaraswami, W Ouyang, Y Belkaid, Z Fehervari   +50 more
core   +3 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Serum amyloid A1 mediates myotube atrophy via Toll‐like receptors

Journal of Cachexia, Sarcopenia and Muscle, 2020
Background Critically ill patients frequently develop muscle atrophy and weakness in the intensive‐care‐unit setting [intensive care unit‐acquired weakness (ICUAW)]. Sepsis, systemic inflammation, and acute‐phase response are major risk factors.
Alexander Hahn, Melanie Kny, Cristina Pablo‐Tortola, Mihail Todiras, Michael Willenbrock, Sibylle Schmidt, Katrin Schmoeckel, Ilka Jorde, Marcel Nowak, Ernst Jarosch, Thomas Sommer, Barbara M. Bröker, Stephan B. Felix, Claus Scheidereit, Steffen Weber‐Carstens, Christian Butter, Friedrich C. Luft, Jens Fielitz   +17 more
doaj   +1 more source

Nous aliats contra la Tuberculosi [PDF]

, 2007
En el segle XXI la tuberculosi continua sent causa d'un important nombre de defuncions cada any. Existeixen vacunes, però la eficàcia que ofereixen no es molt elevada.
Julián Gómez, Esther
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Toll-like receptors in esophageal cancer

Frontiers in Immunology, 2014
Esophageal squamous cell carcinoma and esophageal adenocarcinoma are cancers of high mortality. Esophageal adenocarcinoma develops through Barrett’s esophagus and columnar dysplasia, preceded by gastroesophageal reflux disease.
Joonas H Kauppila, Joonas H Kauppila, Joonas H Kauppila, Joonas H Kauppila, Katri S Selander, Katri S Selander   +5 more
doaj   +1 more source