Results 71 to 80 of about 165,830 (263)

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

Scientific Reports, 2017
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR).
Kelly A. Fader, Rance Nault, Chen Zhang, Kazuyoshi Kumagai, Jack R. Harkema, Timothy R. Zacharewski   +5 more
doaj   +1 more source

Effect of smoking on postprandial secretion of total bile acids

Gastroenterology, 1978
Increased reflux of bile has been associated with gastric mucosal conditions such as gastric ulcer and gastritis. Factors which underlie this observation have not been fully defined although pyloric sphincter dysfunction has been suggested. Since smokinq inhibits pyloric sphincter contraction, changes in bile acid secretion may influence reflux.
Sns Murthy, P Waibel, VP Dinoso, HR Clearfield   +3 more
openaire   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

The U-shaped association between normal-range serum bile acid levels and prognosis of Coronary Heart Disease

Frontiers in Endocrinology
BackgroundPrevious studies have shown that serum total bile acid levels are associated with both the presence of Coronary Heart Disease and the severity of coronary artery lesions.
Yu Xu, Yu Xu, Yu Xu, Ning Ding, Ning Ding, Ning Ding, Rui Hua, Rui Hua, Rui Hua, Yue Wu, Yue Wu, Yue Wu, Ting Li, Ting Li, Ting Li, Zuyi Yuan, Zuyi Yuan, Zuyi Yuan   +17 more
doaj   +1 more source

Effects of d- and l-triiodothyronine and of propylthiouracil on the production of bile acids in the rat

Journal of Lipid Research, 1963
The influence of d- and l-triiodothyronine (DT3 and LT3) and propylthiouracil (PTU) on turnover rate and pool size of bile acids in rats on a normal diet has been investigated.
Ove Strand
doaj   +1 more source

The association of serum total bile acids and deep venous thrombosis

Thrombosis Journal
Bile acid metabolism plays a crucial role in maintaining the delicate balance between coagulation and anticoagulation processes. However, there is a paucity of research exploring the relationship between serum total bile acids (TBA) levels and the risk of deep venous thrombosis (DVT) in Chinese individuals.
Bolin Li, Xinxin Feng, Xinping Kang, Yi Zhao, Miaomiao Cao, Bao Xu, Hui Liu, Shuyi Deng, Yue Wu, Tao Zheng   +9 more
openaire   +3 more sources

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m2.

PLoS ONE, 2014
Bile acids are important endocrine signalling molecules, modulating glucose homeostasis through activation of cell surface and nuclear receptors.
David R Taylor, Jamshid Alaghband-Zadeh, Gemma F Cross, Sohail Omar, Carel W le Roux, Royce P Vincent   +5 more
doaj   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source