Results 71 to 80 of about 1,891 (215)

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

The association of serum total bile acids and deep venous thrombosis

Thrombosis Journal
Bile acid metabolism plays a crucial role in maintaining the delicate balance between coagulation and anticoagulation processes. However, there is a paucity of research exploring the relationship between serum total bile acids (TBA) levels and the risk of deep venous thrombosis (DVT) in Chinese individuals.
Bolin Li, Xinxin Feng, Xinping Kang, Yi Zhao, Miaomiao Cao, Bao Xu, Hui Liu, Shuyi Deng, Yue Wu, Tao Zheng   +9 more
openaire   +3 more sources

Effect of smoking on postprandial secretion of total bile acids

Gastroenterology, 1978
Increased reflux of bile has been associated with gastric mucosal conditions such as gastric ulcer and gastritis. Factors which underlie this observation have not been fully defined although pyloric sphincter dysfunction has been suggested. Since smokinq inhibits pyloric sphincter contraction, changes in bile acid secretion may influence reflux.
Sns Murthy, P Waibel, VP Dinoso, HR Clearfield   +3 more
openaire   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism

Scientific Reports, 2017
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR).
Kelly A. Fader, Rance Nault, Chen Zhang, Kazuyoshi Kumagai, Jack R. Harkema, Timothy R. Zacharewski   +5 more
doaj   +1 more source

Effects of d- and l-triiodothyronine and of propylthiouracil on the production of bile acids in the rat

Journal of Lipid Research, 1963
The influence of d- and l-triiodothyronine (DT3 and LT3) and propylthiouracil (PTU) on turnover rate and pool size of bile acids in rats on a normal diet has been investigated.
Ove Strand
doaj   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m2.

PLoS ONE, 2014
Bile acids are important endocrine signalling molecules, modulating glucose homeostasis through activation of cell surface and nuclear receptors.
David R Taylor, Jamshid Alaghband-Zadeh, Gemma F Cross, Sohail Omar, Carel W le Roux, Royce P Vincent   +5 more
doaj   +1 more source

Serum total bile acid levels in canine dirofilariasis.

The Japanese Journal of Veterinary Science, 1982
The concentrations of serum total bile acids (SBA) were measured by the enzyme-fluorimetric method in 60 dogs with dirofilariasis classified into 4 groups based on the severity of the disease. The results obtained were as follows: the SBA levels in the serious (38.0nM±40.8 (S.D.), n=14) and hemoglobinuria (24.4nM±18.3, n=26) groups were significantly ...
KITAGAWA, Hitoshi, ISHIHARA, Katsuya, YOKOYAMA, Shinji, SASAKI, Yoshihide   +3 more
openaire   +3 more sources

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source