Results 61 to 70 of about 1,891 (215)

Occurrence of sulfated 5α-cholanoates in rat bile1

Journal of Lipid Research, 1978
Bile acids in bile from male and female rats with cannulated bile ducts have been analyzed by repetitive scanning gas–liquid chromatography–mass spectrometry after initial fractionation of conjugate classes on diethylaminohydroxypropyl Sephadex LH-20 ...
H Eriksson, W Taylor, J Sjövall
doaj   +1 more source

Enzymatic methods may underestimate the total serum bile acid concentration.

PLoS ONE, 2020
Enzymatic assays based on bacterial 3α-hydroxysteroid dehydrogenase are the method of choice for quantification of total bile acids (BAs) in serum. Although non-specific, it is generally considered precise and robust.
Kateřina Žížalová, Marek Vecka, Libor Vítek, Martin Leníček   +3 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Serial Total Bile Acid Measurements in Intrahepatic Cholestasis of Pregnancy

Obstetrics & Gynecology
Although peak serum total bile acid (TBA) levels guide management of intrahepatic cholestasis of pregnancy (ICP), whether ICP progresses in severity and when or how to assess bile acid levels serially remains unclear. We conducted a secondary analysis of a single-institution retrospective cohort study to assess bile acid trends across pregnancy among ...
SARKER, Minhazur R., Ramos, Gladys A., Ferrara, Lauren, DEBOLT, Chelsea A.   +3 more
openaire   +5 more sources

Effect of protein on the determination of total bile acids in serum.

Clinical Chemistry, 1983
Abstract We measured total serum bile acids on a fluorescence-light-scattering micro centrifugal analyzer by the direct enzymatic method with 3 alpha-hydroxysteroid dehydrogenase (EC 1.1.1.50) and with resazurin as a fluorogenic electron acceptor.
N Q, Hanson, E F, Freier
openaire   +2 more sources

Miniature Soft Robot With Magnetically Reprogrammable Surgical Functions

Advanced Materials, EarlyView.
Miniature soft robots have great prospects to revolutionize minimally invasive treatments. Here we present a miniature soft robot, which can be reprogrammed to perform five surgical functionalities with six‐degrees‐of‐freedom motions. This soft robot can prospectively make minimally invasive surgery considerably safer and painless, and enable ...
Chelsea Shan Xian Ng, Yu Xuan Yeoh, Nicholas Yong Wei Foo, Keerthana Radhakrishnan, Guo Zhan Lum   +4 more
wiley   +1 more source

Dietary bile acid supplementation improves the intestinal health and growth performance of piglets partially through the FXR/AQPs pathway

Porcine Health Management
Background Maintaining the integrity of the structure and function of piglet intestines is crucial for their growth and health. This study aims to evaluate the effects of an antibiotic free diet supplemented with bile acid on gut health and growth ...
Beibei Zhang, Min Tian, Yahui Yang, Yueqin Qiu, Li Wang, Hao Xiao, Xiaoping Zhu, Limei Qin, Xuefen Yang, Zongyong Jiang   +9 more
doaj   +1 more source

Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice

Journal of Lipid Research, 2017
The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1α/X-box binding protein 1 (IRE1α/XBP1) pathway of the UPR is important in lipid metabolism.
Xiaoying Liu, Anne S. Henkel, Brian E. LeCuyer, Susan C. Hubchak, Matthew J. Schipma, Eric Zhang, Richard M. Green   +6 more
doaj   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source