Results 1 to 10 of about 12,937,279 (239)
The Total Synthesis of (−)-Scabrolide A [PDF]
Journal of the American Chemical Society, 2020 The first total synthesis of the norcembranoid diterpenoid scabrolide A is disclosed. The route begins with the synthesis of two chiral pool-derived fragments, which undergo a convergent coupling to expediently introduce all 19 carbon atoms of the natural product.
Nicholas J. Hafeman +5 more
openaire +8 more sources
Total synthesis of teixobactin [PDF]
Nature Communications, 2016 To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions.
K. Jin +7 more
semanticscholar +8 more sources
Total Synthesis of Entecavir [PDF]
The Journal of Organic Chemistry, 2013 Entecavir (BMS-200475) was synthesized from 4-trimethylsilyl-3-butyn-2-one and acrolein. The key features of its preparation are: (i) a stereoselective boron-aldol reaction to afford the acyclic carbon skeleton of the methylenecylopentane moiety; (ii) its cyclization by a Cp2TiCl-catalyzed intramolecular radical addition of an epoxide to an alkyne; and
Martí Bartra +10 more
openaire +7 more sources
Total Synthesis of (-)-Himalensine A.
Journal of the American Chemical Society, 2017 The first enantioselective synthesis of (-)-himalensine A has been achieved in 22 steps. The synthesis was enabled by a novel catalytic, enantioselective prototropic shift/furan Diels-Alder (IMDAF) cascade to construct the ACD tricyclic core. A reductive
Heyao Shi +6 more
semanticscholar +7 more sources
The Total Synthesis of Chondrochloren A [PDF]
Angewandte Chemie, 2021 AbstractThe first total synthesis of chondrochloren A is accomplished using a 1,2‐metallate rearrangement addition as an alternative for the Nozaki‐Hiyama‐Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks.
Yannick Linne +4 more
openaire +5 more sources
ESTRATÉGIAS PARA A SÍNTESE DO ÁCIDO LISÉRGICO
Química Nova, 2021 STRATEGIES FOR THE SYNTHESIS OF LYSERGIC ACID. (+)-Lysergic acid [(+)-1] is a precursor of several substances with well-established pharmacological properties, including some drugs approved and commercialized around the world. Thus, the importance of (+)-
Tamiris R. C. Silva, Cristiano Raminelli
doaj +1 more source
Chemoenzymatic Total Synthesis of Natural Products.
Accounts of Chemical Research, 2021 ConspectusThe total synthesis of structurally complex natural products has challenged and inspired generations of chemists and remains an exciting area of active research. Despite their history as privileged bioactivity-rich scaffolds, the use of natural
Suman Chakrabarty +4 more
semanticscholar +1 more source
Total Synthesis of (+)‐Epiquinamide. [PDF]
ChemInform, 2005 The stereoselective total synthesis of the novel quinolizidine alkaloid (+)-epiquinamide is presented, starting from the amino acid l-allysine ethylene acetal. Key steps in the synthesis involved a highly diastereoselective N-acyliminium ion allylation and a ring-closing metathesis reaction to provide the bicyclic skeleton. [reaction: see text]
Wijdeven, M.A. +5 more
openaire +6 more sources
Total Synthesis of (−)-Borrelidin [PDF]
Organic Letters, 2004 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kazuhiko Otoguro +9 more
openaire +6 more sources
Total Synthesis of (+)‐Yatakemycin. [PDF]
ChemInform, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hidetoshi Tokuyama +3 more
openaire +6 more sources