Results 1 to 10 of about 16,454,265 (355)
The Total Synthesis of (–)-Scabrolide A [PDF]
Journal of the American Chemical Society, 2020 The first total synthesis of the norcembranoid diterpenoid scabrolide A is disclosed. The route begins with the synthesis of two chiral pool-derived fragments, which undergo a convergent coupling to expediently introduce all 19 carbon atoms of the ...
Hafeman, Nicholas J. +5 more
core +2 more sources
Total synthesis of (-)-kaitocephalin [PDF]
Organic Letters, 2005 博士(理学 ...
川崎, 昌紀
core +4 more sources
Total synthesis of jiadifenolide. [PDF]
Angewandte Chemie International Edition, 2014 As a potent neurotrophic agent, the sesquiterpenoid jiadifenolide represents a valuable small-molecule lead for the potential therapeutic treatment of neurodegenerative diseases.
Dalby, Stephen M +2 more
core +6 more sources
Total synthesis of teixobactin [PDF]
Nature Communications, 2016 To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions.
K. Jin +7 more
semanticscholar +6 more sources
Total Synthesis of (+)‐Cornexistin [PDF]
Angewandte Chemie, 2020 AbstractHerein, we describe the first total synthesis of (+)‐cornexistin as well as its 8‐epi‐isomer starting from malic acid. The robust and scalable route features a Nozaki–Hiyama–Kishi reaction, an auxiliary‐controlled syn‐Evans‐aldol reaction, and a highly efficient intramolecular alkylation to form the nine‐membered carbocycle. The delicate maleic
Christian Steinborn +3 more
openaire +3 more sources
Chemoenzymatic Total Synthesis of Natural Products.
Accounts of Chemical Research, 2021 ConspectusThe total synthesis of structurally complex natural products has challenged and inspired generations of chemists and remains an exciting area of active research. Despite their history as privileged bioactivity-rich scaffolds, the use of natural
Suman Chakrabarty +4 more
semanticscholar +1 more source
Total Synthesis of (+)‐Epiquinamide. [PDF]
ChemInform, 2005 The stereoselective total synthesis of the novel quinolizidine alkaloid (+)-epiquinamide is presented, starting from the amino acid l-allysine ethylene acetal. Key steps in the synthesis involved a highly diastereoselective N-acyliminium ion allylation and a ring-closing metathesis reaction to provide the bicyclic skeleton. [reaction: see text]
Wijdeven, M.A. +5 more
openaire +4 more sources
Atroposelective Total Synthesis of Darobactin A.
Journal of the American Chemical Society, 2022 A concise, modular synthesis of the novel antibiotic darobactin A is disclosed. The synthesis successfully forges the hallmark strained macrocyclic ring systems in a sequential fashion.
You-Chen Lin +8 more
semanticscholar +1 more source
Total Synthesis of Asperazine [PDF]
Journal of the American Chemical Society, 2001 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
S P, Govek, L E, Overman
openaire +3 more sources
Tetrahedron Letters, 2022 Remdesivir, the first drug approved by the FDA to treat COVID-19, is in high demand for patients infected with the SARS-CoV-2 virus. Herein, we report a facile approach minimizing the protecting group manipulations to afford remdesivir in good overall yield.
Kumar Palli, Kishore +9 more
openaire +2 more sources