Results 91 to 100 of about 12,937,378 (338)
Optimization of Two Steps in Scale-Up Synthesis of Nannocystin A
Marine Drugs, 2021 We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol reaction to connect C4 and C5 was unreproducible during the scaling up ...
Tingrong Zhang +5 more
doaj +1 more source
Organocatalysis in total synthesis [PDF]
, 2015 Peer ...
Herrera, Raquel P. +1 more
core +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Synthetic Approaches to the Lamellarins—A Comprehensive Review
Marine Drugs, 2014 The present review discusses the known synthetic routes to the lamellarin alkaloids published until 2014. It begins with syntheses of the structurally simpler type-II lamellarins and then focuses on the larger class of the 5,6-saturated and -unsaturated ...
Dennis Imbri +2 more
doaj +1 more source
Enantioselective Total Synthesis of (—)-Acetylaranotin, a Dihydrooxepine Epidithiodiketopiperazine [PDF]
, 2012 The first total synthesis of the dihydrooxepine-containing epidithiodiketopiperazine (ETP) (−)-acetylaranotin (1) is reported. The key steps of the synthesis include an enantioselective azomethine ylide (1,3)-dipolar cycloaddition reaction to set the ...
Codelli, Julian A. +2 more
core +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Recent applications of the divinylcyclopropane–cycloheptadiene rearrangement in organic synthesis
Beilstein Journal of Organic Chemistry, 2014 This review summarizes the application of the divinylcyclopropane–cycloheptadiene rearrangement in synthetic organic chemistry. A brief overview of the new mechanistic insights concerning the title reaction is provided as well as a condensed account on ...
Sebastian Krüger, Tanja Gaich
doaj +1 more source
Synthesis and analysis in total variation regularization [PDF]
arXiv, 2019 We generalize the bridge between analysis and synthesis estimators by Elad, Milanfar and Rubinstein (2007) to rank deficient cases. This is a starting point for the study of the connection between analysis and synthesis for total variation regularized estimators. In particular, the case of first order total variation regularized estimators over general
arxiv
Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products.
Chemical Reviews, 2017 The pool of abundant chiral terpene building blocks (i.e., "chiral pool terpenes") has long served as a starting point for the chemical synthesis of complex natural products, including many terpenes themselves.
Zachary G. Brill +3 more
semanticscholar +1 more source
The Total Synthesis of (−)-Lemonomycin [PDF]
Journal of the American Chemical Society, 2003 The first total synthesis of the novel glycosylated tetrahydroisoquinoline antitumor antibiotic (-)-lemonomycin has been accomplished (15 steps from 9). The highly convergent synthesis relies on a key asymmetric dipolar cycloaddition to set the stereochemistry of the aglycone core, a Suzuki fragment coupling to connect the diazabicycle to the aryl ...
Ashley, Eric R. +2 more
openaire +6 more sources