Results 91 to 100 of about 3,850,300 (360)

Synthesis of Pelorol and Its Analogs and Their Inhibitory Effects on Phosphatidylinositol 3-Kinase

Marine Drugs, 2016
There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that
Yongjie Luo, Huixuan Chen, Jiang Weng, Gui Lu   +3 more
doaj   +1 more source

Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: Applications to the total synthesis of alkaloids [PDF]

, 2008
Enantioselective syntheses of the alkaloids (-)-aurantioclavine, (+)-amurensinine, (-)-lobeline, and (-)- and (+)-sedamine are described. The syntheses demonstrate the effectiveness of the Pd-catalyzed asymmetric oxidation of secondary alcohols in ...
Bagdanoff, Jeffrey T., Ebner, David C., Krishnan, Shyam, Ramtohul, Yeeman K., Stoltz, Brian M., Tambar, Uttam K.   +5 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Evolution of a Strategy for the Total Synthesis of the Ganoderma Meroterpenoid Ganoapplanin

ChemistryEurope
Herein, a detailed account of the efforts leading to the recently published synthesis of the Ganoderma meroterpenoid ganoapplanin, a natural product identified as an inhibitor of T‐type voltage‐gated calcium channels, is provided. Ganoapplanin, which was
Nicolas Müller, Ondřej Kováč, Alexander Rode, Daniel Atzl, Clemens Dietrich, Ana V. Serna, Sebastian Schaar, Antonio Paparesta, Julian Lichtenegger, Thomas Magauer   +9 more
doaj   +1 more source

Total Synthesis of Talarolide A and atrop-Talarolide A: Hydroxamate H-Bond Bridge Stabilization of Cyclic Peptide Conformers Invokes Non-Canonical Atropisomerism

Marine Drugs
The first total synthesis of the Australian marine tunicate fungus-derived cyclic peptide talarolide A (1) has confirmed the structure previously proposed on the basis of spectroscopic and chemical analyses and re-affirmed the importance of the unique ...
Waleed M. Hussein, Yuxuan Zhu, Angela A. Salim, Robert J. Capon   +3 more
doaj   +1 more source

Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs

Marine Drugs, 2015
Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM).
Xiaoji Wang, Chanshan Lv, Junmin Feng, Linjun Tang, Zhuo Wang, Yuqing Liu, Yi Meng, Tao Ye, Zhengshuang Xu   +8 more
doaj   +1 more source

Restoration of Poissonian Images Using Alternating Direction Optimization [PDF]

, 2010
Much research has been devoted to the problem of restoring Poissonian images, namely for medical and astronomical applications. However, the restoration of these images using state-of-the-art regularizers (such as those based on multiscale ...
Bioucas-Dias, José M., Figueiredo, Mário A. T.   +1 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A síntese dos sesquiterpenos baquenolidas The synthesis of the bakkenolide sesquiterpenes

Química Nova, 2008
The bakkenolide group of sesquiterpenes has been a focal point of synthetic efforts amongst several research laboratories all linked to our common origins at the Chemistry Institute at the State University in São Paulo.
Timothy John Brocksom, Ursula Brocksom, Maurício G. Constantino   +2 more
doaj   +1 more source

Stereoisomer libraries: Total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach [PDF]

, 2004
All 16 stereoisomers of the sex pheromone of pine sawfly (3,7,11-trimethylundecanol propanoate ester) have been synthesized on a 10- to 20-mg scale by a split-parallel fluorous mixture-synthesis approach.
Curran, D. P. Curran, Hedenstr  m, Houghten, Luo, M. Jeske, S. Dandapani, Zhang, Zhang, Zhang   +9 more
core   +3 more sources