The Tumor Suppressor TPD52‐Governed Endoplasmic Reticulum Stress is Modulated by APCCdc20 [PDF]
Advanced ScienceAberrant regulation of unfolded protein response (UPR)/endoplasmic reticulum (ER) stress pathway is associated with cancer development, metastasis, and relapse, and the UPR signal transducer ATF6 has been proposed as a diagnostic and prognostic marker ...
Weichao Dan +15 more
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TPD52 promotes the proliferation and metastasis of gastric cancer cells [PDF]
BMC GastroenterologyImmunotherapy has improved outcomes for tumor patients, but only a small proportion benefits due to genetic and immunological resistance. Enhancing its efficacy is crucial.
Shunhao Zhang +7 more
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Comprehensive analysis of the LINC01122/TPD52 axis as a predictive biomarker in prostate adenocarcinoma [PDF]
Scientific ReportsProstate cancer (PCa) ranks among the most prevalent malignant tumors worldwide. The pivotal role of competitive endogenous RNA (ceRNA) regulatory networks in numerous cancer types has been underscored.
Zhi Shang +7 more
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Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK [PDF]
Cancer Medicine, 2023 Background The AMP‐activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases. However, how this pathway is dysregulated in cancer has not been well clarified.
Yali Chen +8 more
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Preclinical support for tumor protein D52 as a cancer vaccine antigen [PDF]
Human Vaccines & Immunotherapeutics, 2023 Overexpressed tumor-associated antigens (TAAs) are a large group that includes proteins found at increased levels in tumors compared to healthy cells. Universal tumor expression can be defined as overexpression in all cancers examined as has been shown ...
Robert K. Bright
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Hsa_circ_0007637 Facilitates Nasopharyngeal Carcinoma Progression by Sponging miR-636/TPD52 Axis
Cancer Management and Research, 2021 Yihong Wang,* Manyi Li,* Chen Pan,* Haiping Huang, Xiaoqing Hu, Jisheng Liu Department of Otolaryngology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this ...
Wang Y +5 more
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Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis [PDF]
Parasites & Vectors, 2021 Background Trichinella spiralis (T. spiralis) is a parasite occurring worldwide that has been proven to have antitumour ability. However, studies on the antitumour effects of cross antigens between the tumour and T.
Tao-Tao Yue +10 more
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Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer [PDF]
Journal of Ovarian Research, 2023 Background Gynecologic cancers comprise malignancies in the female reproductive organs. Ovarian cancer ranks sixth in terms of incidence rates while seventh in terms of mortality rates. The stage at which ovarian cancer is diagnosed mainly determines the
Khushbukhat Khan +10 more
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Unpacking the Tumor Protein D52-like Family: Roles in Intracellular Trafficking and Cancer Progression [PDF]
CellsThere is growing evidence that dysregulation of vesicle-mediated intracellular trafficking pathways leads to the development of various diseases, including cancer. Cancer exploits the intracellular trafficking pathways to modulate the protein flow, alter
Emma L. Dorward +7 more
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Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression. [PDF]
Int J Biol Sci, 2023 Lung cancer, as the most commonly diagnosed malignancy, still accounts for the leading cause of cancer-related deaths worldwide. The high rate of mortality and tumor recurrence has prompted clinicians and scientists to urgently explore new targets for improved treatment.
Liu S +5 more
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