Preclinical support for tumor protein D52 as a cancer vaccine antigen [PDF]
Human Vaccines & Immunotherapeutics, 2023 Overexpressed tumor-associated antigens (TAAs) are a large group that includes proteins found at increased levels in tumors compared to healthy cells. Universal tumor expression can be defined as overexpression in all cancers examined as has been shown ...
Robert K. Bright
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TPD52 promotes the proliferation and metastasis of gastric cancer cells [PDF]
BMC GastroenterologyImmunotherapy has improved outcomes for tumor patients, but only a small proportion benefits due to genetic and immunological resistance. Enhancing its efficacy is crucial.
Shunhao Zhang +7 more
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Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer [PDF]
Journal of Ovarian Research, 2023 Background Gynecologic cancers comprise malignancies in the female reproductive organs. Ovarian cancer ranks sixth in terms of incidence rates while seventh in terms of mortality rates. The stage at which ovarian cancer is diagnosed mainly determines the
Khushbukhat Khan +10 more
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MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome [PDF]
BMC Cancer, 2010 Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12.
Fanayan Susan +11 more
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The Tumor Suppressor TPD52‐Governed Endoplasmic Reticulum Stress is Modulated by APCCdc20 [PDF]
Advanced ScienceAberrant regulation of unfolded protein response (UPR)/endoplasmic reticulum (ER) stress pathway is associated with cancer development, metastasis, and relapse, and the UPR signal transducer ATF6 has been proposed as a diagnostic and prognostic marker ...
Weichao Dan +15 more
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Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK [PDF]
Cancer Medicine, 2023 Background The AMP‐activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases. However, how this pathway is dysregulated in cancer has not been well clarified.
Yali Chen +8 more
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Comprehensive analysis of the LINC01122/TPD52 axis as a predictive biomarker in prostate adenocarcinoma [PDF]
Scientific ReportsProstate cancer (PCa) ranks among the most prevalent malignant tumors worldwide. The pivotal role of competitive endogenous RNA (ceRNA) regulatory networks in numerous cancer types has been underscored.
Zhi Shang +7 more
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KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis [PDF]
Cancer Biology & TherapyIn this study, we aimed to investigate the molecular mechanism of Krüppel-like factor 7 (KLF7) in colorectal cancer (CRC) cell invasion and migration. The expression pattern of KLF7 in CRC tissues and the correlation between KLF7 expression and clinical ...
Juan Zhang +5 more
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Unpacking the Tumor Protein D52-like Family: Roles in Intracellular Trafficking and Cancer Progression [PDF]
CellsThere is growing evidence that dysregulation of vesicle-mediated intracellular trafficking pathways leads to the development of various diseases, including cancer. Cancer exploits the intracellular trafficking pathways to modulate the protein flow, alter
Emma L. Dorward +7 more
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Tumor Protein D53 (TPD53): Involvement in Malignant Transformation of Low-Malignant Oral Squamous Cell Carcinoma Cells [PDF]
BiomedicinesBackground/Objectives: The tumor protein D52 (TPD52) family includes TPD52, TPD53, TPD54, and TPD55. The balance between TPD52 and TPD54 expression plays an important role in high-malignant oral squamous cell carcinoma (OSCC) cells.
Masataka Watanabe +8 more
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