Results 61 to 70 of about 2,258 (177)

MicroRNA‑103a‑3p promotes metastasis by targeting TPD52 in salivary adenoid cystic carcinoma

International Journal of Oncology, 2020
Salivary adenoid cystic carcinoma (SACC) exhibits slow continuous growth, frequent local recurrences and a high incidence of blood metastasis, with advanced lung metastasis frequently occurring and being among the primary causes of mortality. MicroRNAs (miR) serve a significant role in the initiation and development of cancer and may be tumour‑specific
Min Fu, Chuwen Chen, Lin‐Qian Yang, Wenwen Yang, Zhi‐Hao Du, Yin‐Ran Li, Shenglin Li, Xi‐Yuan Ge   +7 more
openaire   +3 more sources

Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: Prolonged survival [PDF]

Vaccine, 2009
Peptide-based vaccines, one of several anti-tumor immunization strategies currently under investigation, can elicit both MHC Class I-restricted (CD8(+)) and Class II-restricted (CD4(+)) responses. However, the need to identify specific T-cell epitopes in the context of MHC alleles has hampered the application of this approach.
Saied, Mirshahidi, Victor G, Kramer, James B, Whitney, Sosthène, Essono, Sandra, Lee, Glenn, Dranoff, Karen S, Anderson, Ruth M, Ruprecht   +7 more
openaire   +2 more sources

Promotive role of USP29-mediated deubiquitination in malignant proliferation of colorectal cancer cells via the KIAA1429/SOX8 axis

Biomolecules & Biomedicine, 2023
Colorectal cancer (CRC) is regarded as one of the most prevalent neoplasms worldwide, and ubiquitination and N6-methyladenosine (m6A) modification regulate the outgrowth of multiple cancers.
Juncai Li, Jianguo Yang, Zhenzhou Chen, Li Liu, Hao Wang, Qican Deng, Yajun Chen, Yong Que, Zhongxue Fu   +8 more
doaj   +1 more source

Identification of genomic markers correlated with sensitivity in solid tumors to Dasatinib using sparse principal components [PDF]

, 2016
Background: Differential analysis techniques are commonly used to offer scientists a dimension reduction procedure and an interpretable gateway to variable selection, especially when confronting high-dimensional genomic data. Huang et al.
Ahmed Hossain, Hafiz T.A. Khan, Michaels G.S., Raychaudhuri S., Tibshirani R.   +4 more
core   +1 more source

Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells

Scientific Reports, 2021
Prostate cancer (PCa) is dependent on the androgen receptor (AR). Advanced PCa is treated with an androgen deprivation therapy-based regimen; tumors develop resistance, although they typically remain AR-dependent.
Manjul Rana, Jianrong Dong, Matthew J. Robertson, Cristian Coarfa, Nancy L. Weigel   +4 more
doaj   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain‐first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain unclear. METHODS We conducted a proteomic and microbial analysis of transverse colon samples from clinically and pathologically confirmed AD and ...
Qiwen Cheng, Jennifer Nolz, Timothy Karr, Nicole Dorn, Benjamin Readhead, Rosa Krajmalnik‐Brown, Diego Mastroeni   +6 more
wiley   +1 more source

Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer

Autophagy, 2021
Aberrant chaperone-mediated autophagy (CMA) activation has been suggested as a tumorigenesis-promoting event in various cancers, although its roles in prostate cancer (PCa) remain elusive. Emerging evidence indicates that TPD52 isoform 1, a prostate-specific and androgen-responsive gene, contributes to the malignant progression of PCa.
Yizeng, Fan, Tao, Hou, Yang, Gao, Weichao, Dan, Tianjie, Liu, Bo, Liu, Yule, Chen, Hongjun, Xie, Zhao, Yang, Jiaqi, Chen, Jin, Zeng, Lei, Li   +11 more
openaire   +2 more sources

Integration of copy number and transcriptomics provides risk stratification in prostate cancer : a discovery and validation cohort study [PDF]

, 2017
Study data are deposited in NCBI GEO (unique identifier number GSE70770).Background : Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease.
Aho, Tevita, Baridi, Ajoeb, Basnett, Gillian, Burge, Jo, CamCaP Study Group, Clark, J., Cooper, C. S., Corcoran, Marie, Coret, Hansley, Cromwell, Elizabeth, Doble, Andrew, Dunning, M. J., Egevad, L. A., Francis, Indu, George, Anne, Gnanapragasam, V. J., Gnanpragasam, Vincent, Grönberg, H., Halim, S., Haynes, Beverley, Hori, Satoshi, Hurst, R., Kastner, Christof, Kay, J., Lamb, A. D., Lindberg, J., Luxton, Hayley, Lynch, A. G., Massie, C. M., Mills, I. G., Neal, D. E., Nelson, Adam, Partridge, Wendy, Patel, Keval, Ramos-Montoya, A., Ross-Adams, H., Russell, R., Sangrasi, Asif, Shah, N. C., Sharma, N. L., Shaw, Greg, Stark, R., Stearn, Sara, Thomas, Benjamin, Tran, Maxine, Vowler, S. L., Wadhwa, Karan, Warren, A. Y., Whitaker, H., Whitington, Thomas, Yuan, Yinyin   +50 more
core   +1 more source

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source