Results 81 to 90 of about 2,290 (178)
Functional significance of Tumor Protein D52 amplification and overexpression in cancer [PDF]
, 2018 Tumor Protein D52 (TPD52) is an oncogene whose overexpression has been demonstrated in tumours of diverse cellular origins and associated with poor prognosis.
Frost, Sarah
core
IET Systems Biology, Volume 19, Issue 1, January/December 2025.This study investigates the role of ADAMTS5 in breast cancer, revealing its low expression in tumour samples and its involvement in key pathways such as ECM‐receptor interactions and cell cycle regulation. A novel prognostic model was identified, highlighting interactions between ADAMTS5 and proteins such as COL10A1 and MMP1, as well as regulatory ...
Najmeh Tavousi +5 more
wiley +1 more source
Human Mutation, Volume 2025, Issue 1, 2025.Background: Heterogenized sphingolipid metabolism (SM) drives osteosarcoma tumorigenesis and its tumor‐promoting microenvironment. State‐of‐the‐art bioinformatic tools, such as machine learning, are essential for dissecting the prognostic value of SM by investigating its molecular and cellular mechanisms.
Yujian Zhong +6 more
wiley +1 more source
Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells
Tumor Biology, 2016 The tumour protein D52 isoform 1 (PC-1), a member of the tumour protein D52 (TPD52) protein family, is androgen-regulated and prostate-specific expressed. Previous studies confirmed that PC-1 contributes to malignant progression in prostate cancer with an important role in castration-resistant stage.
Moritz, Tom +5 more
openaire +3 more sources
Role of tumor protein D52 in tumor occurrence and development, and its potential application value in tumor diagnosis and therapy [PDF]
, 2016 肿瘤蛋白D52(TPD52)在乳腺癌、前列腺癌、肺癌、卵巢癌和血液系统恶性病变等多种肿瘤中高表达,可参与肿瘤细胞增殖、侵袭、转移以及抑制DNA修复等生物学行为,并诱导机体产生对肿瘤的保护性免疫,是肿瘤诊断与分子靶向治疗中最有应用前景的候选蛋白之一。笔者对TPD52在肿瘤中发生发展的作用及其在肿瘤诊疗中潜在应用价值进行综述,旨在为TPD52进一步研究指明方向,更好实现其临床价值。Tumor protein D52(TPD52), which is involved in tumor cell ...
周思佳, 陈波, 骆明旭
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Ruolo del sistema ubiquitina-proteasoma (UPS) nella disfunzione beta cellulare del diabete di tipo 2 e possibili opzioni terapeutiche. [PDF]
, 2011 Ruolo del sistema ubiquitina-proteasoma (UPS) nella disfunzione beta cellulare del diabete di tipo 2 e possibili opzioni terapeutiche. Sebbene la disfunzione beta cellulare rivesta un ruolo di primaria importanza nel diabete di tipo 2, le informazioni ad
BUGLIANI, MARCO
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Biology of childhood germ cell tumours, focussing on the significance of microRNAs. [PDF]
, 2014 Genomic and protein-coding transcriptomic data have suggested that germ cell tumours (GCTs) of childhood are biologically distinct from those of adulthood.
Coleman, N, Murray, MJ, Nicholson, JC
core +2 more sources
Circular RNAs in human diseases
MedComm, Volume 5, Issue 9, September 2024.Circular RNAs (circRNAs) play significant roles in various human diseases, including respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, renal diseases, and cancer. This review highlights their biogenesis, pathogenic potential, and potential applications as diagnostic biomarkers and therapeutic targets. Abstract Circular RNAs (circRNAs)
Yuanyong Wang +10 more
wiley +1 more source
Tumor Proteins D52 and D54 Have Opposite Effects on the Terminal Differentiation of Chondrocytes [PDF]
, 2017 The tumor protein D (TPD) family consists of four members, TPD52, TPD53, TPD54, and TPD55. The physiological roles of these genes in normal tissues, including epidermal and mesenchymal tissues, have rarely been reported.
Chihiro Ito +7 more
core +2 more sources
Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan +16 more
wiley +1 more source