Results 81 to 90 of about 2,258 (177)

BCL2, IRS1, AKT3, PTEN, and HIF1A expression levels in non‐small cell lung cancer patients

Malignancy Spectrum, Volume 2, Issue 1, Page 37-45, March 2025.
Restoration of miR‐15/16, miR‐126, and miR‐128 in NSCLC might be therapeutic candidates to control cell proliferation and apoptosis. Abstract Background Lung cancer is the leading cause of cancer‐related deaths worldwide. MicroRNAs (miRNAs) are small noncoding molecules that play critical roles in cell proliferation, apoptosis, invasion, and metastasis,
Mahdi Mohammadi, Kiana Taheri, Shamim Fooladgar, Saghar Omidvar Masoumi, Elham Tafsiri   +4 more
wiley   +1 more source

The imminent role of microRNAs in salivary adenoid cystic carcinoma

Translational Oncology, 2023
Unfortunately, despite the severe problem associated with salivary adenoid cystic carcinoma (SACC), it has not been studied in detail yet. Therefore, the time has come to understand the oncogenic cause of SACC and find the correct molecular markers for ...
Pawan Kumar, Ram Kumar Kumawat, Vivek Uttam, Alisha Behera, Medha Rani, Neha Singh, Tushar Singh Barwal, Uttam Sharma, Aklank Jain   +8 more
doaj   +1 more source

Inhibiting Tumor Protein D52 function for anti-cancer therapy application [PDF]

, 2013
Tumor protein D52 (TPD52) is amplified and/or overexpressed in many cancer types. Previously, TPD52 expression has been associated with ERBB2, suggesting these oncogenes may co-operate in cancer pathogenesis.
Roslan, Nuruliza
core  

ADAMTS5 Modulates Breast Cancer Development as a Diagnostic Biomarker and Potential Tumour Suppressor, Regulated by BAIAP2‐AS1, CRNDE and hsa‐miR‐135b‐3p: Integrated Systems Biology and Experimental Approach

IET Systems Biology, Volume 19, Issue 1, January/December 2025.
This study investigates the role of ADAMTS5 in breast cancer, revealing its low expression in tumour samples and its involvement in key pathways such as ECM‐receptor interactions and cell cycle regulation. A novel prognostic model was identified, highlighting interactions between ADAMTS5 and proteins such as COL10A1 and MMP1, as well as regulatory ...
Najmeh Tavousi, Qazal Taqizadeh, Elnaz Nasiriyan, Parastoo Tabaeian, Mohammad Rezaei, Mansoureh Azadeh   +5 more
wiley   +1 more source

Functional significance of Tumor Protein D52 amplification and overexpression in cancer [PDF]

, 2018
Tumor Protein D52 (TPD52) is an oncogene whose overexpression has been demonstrated in tumours of diverse cellular origins and associated with poor prognosis.
Frost, Sarah
core  

Bayesian Optimization–Enhanced Machine Learning for Osteosarcoma Risk Stratification Based on Sphingolipid Metabolism

Human Mutation, Volume 2025, Issue 1, 2025.
Background: Heterogenized sphingolipid metabolism (SM) drives osteosarcoma tumorigenesis and its tumor‐promoting microenvironment. State‐of‐the‐art bioinformatic tools, such as machine learning, are essential for dissecting the prognostic value of SM by investigating its molecular and cellular mechanisms.
Yujian Zhong, Ruyuan He, Zewen Jiang, Queran Lin, Fei Peng, Wenyi Jin, Minghua Ren   +6 more
wiley   +1 more source

Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells

Tumor Biology, 2016
The tumour protein D52 isoform 1 (PC-1), a member of the tumour protein D52 (TPD52) protein family, is androgen-regulated and prostate-specific expressed. Previous studies confirmed that PC-1 contributes to malignant progression in prostate cancer with an important role in castration-resistant stage.
Moritz, Tom, Venz, Simone, Junker, Heike, Kreuz, Sarah, Walther, Reinhard, Zimmermann, Uwe   +5 more
openaire   +3 more sources

Circular RNAs in human diseases

MedComm, Volume 5, Issue 9, September 2024.
Circular RNAs (circRNAs) play significant roles in various human diseases, including respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, renal diseases, and cancer. This review highlights their biogenesis, pathogenic potential, and potential applications as diagnostic biomarkers and therapeutic targets. Abstract Circular RNAs (circRNAs)
Yuanyong Wang, Jin Zhang, Yuchen Yang, Zhuofeng Liu, Sijia Sun, Rui Li, Hui Zhu, Tian Li, Jin Zheng, Jie Li, Litian Ma   +10 more
wiley   +1 more source

Biology of childhood germ cell tumours, focussing on the significance of microRNAs. [PDF]

, 2014
Genomic and protein-coding transcriptomic data have suggested that germ cell tumours (GCTs) of childhood are biologically distinct from those of adulthood.
Coleman, N, Murray, MJ, Nicholson, JC
core   +2 more sources

Optimization of ultracentrifugation‐based method to enhance the purity and proteomic profiling depth of plasma‐derived extracellular vesicles and particles

Journal of Extracellular Biology, Volume 3, Issue 7, July 2024.
Abstract Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in‐depth analysis of the EVP proteome. Here, we compared the effectiveness of
Zurong Wan, Jinghua Gu, Uthra Balaji, Linda Bojmar, Henrik Molina, Søren Heissel, Alexandra E. Pagano, Christopher Peralta, Lee Shaashua, Dorina Ismailgeci, Hope K. Narozniak, Yi Song, William R. Jarnagin, David P. Kelsen, Jaqueline Bromberg, Virginia Pascual, Haiying Zhang   +16 more
wiley   +1 more source