Results 31 to 40 of about 61,594 (230)
β-Glucan-Induced Trained Immunity in Dogs
Frontiers in Immunology, 2020 Several observations in the world of comparative immunology in plants, insects, fish and eventually mammals lead to the discovery of trained immunity in the early 2010's. The first demonstrations provided evidence that innate immune cells were capable of
Simon Paris +12 more
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Immunometabolic control of trained immunity
Molecular Aspects of Medicine, 2021 Innate immune cells can adopt long-term inflammatory phenotypes following brief encounters with exogenous (microbial) or endogenous stimuli. This phenomenon is named trained immunity and can improve host defense against (recurrent) infections. In contrast, trained immunity can also be maladaptive in the context of chronic inflammatory disorders, such ...
Riksen, Niels P., Netea, Mihai G.
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Trained immunity in atherosclerotic cardiovascular disease [PDF]
Nature Reviews Cardiology, 2021 Atherosclerosis is characterized by incessant inflammation in the arterial wall in which monocytes and macrophages play a crucial role. During the past few years, it has been reported that cells from the innate immune system can develop a long-lasting proinflammatory phenotype after brief stimulation not only with microbial products but also endogenous
Flores Gomez, D. +4 more
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Innate immune memory, trained immunity and nomenclature clarification [PDF]
Nature Immunology, 2023 Contains fulltext : 295907.pdf (Publisher’s version ) (Open Access)
George Hajishengallis +2 more
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Bacillus Calmette–Guérin Immunotherapy for Cancer
Vaccines, 2021 Bacillus Calmette–Guérin (BCG), an attenuated vaccine from Mycobacterium bovis, was initially developed as an agent for vaccination against tuberculosis.
Fabíola Cardillo +5 more
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Trained immunity in organ transplantation [PDF]
American Journal of Transplantation, 2020 Consistent induction of donor-specific unresponsiveness in the absence of continuous immunosuppressive therapy and toxic effects remains a difficult task in clinical organ transplantation. Transplant immunologists have developed numerous experimental treatments that target antigen-presentation (signal 1), costimulation (signal 2), and cytokine ...
Ochando, J. +5 more
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Trained Immunity as an Adaptive Branch of Innate Immunity [PDF]
International Journal of Molecular Sciences, 2021 The concept of trained immunity has become one of the most interesting and potentially commercially and clinically relevant ideas of current immunology. Trained immunity is realized by the epigenetic reprogramming of non-immunocompetent cells, primarily monocytes/macrophages and natural killer (NK) cells, and is less specific than adaptive immunity ...
Vaclav Vetvicka +2 more
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Immunometabolic circuits in trained immunity [PDF]
Seminars in Immunology, 2016 The classical view that only adaptive immunity can build immunological memory has recently been challenged. Both in organisms lacking adaptive immunity as well as in mammals, the innate immune system can adapt to mount an increased resistance to reinfection, a de facto innate immune memory termed trained immunity.
Arts, R.J., Joosten, L.A., Netea, M.G.
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Journal of Medical Science, 2021 Though SARS-CoV-2 infections are yet to be completely characterised in a host-pathogen interaction context, some of the mechanisms governing the interaction between the novel betacoronavirus and the human host, have been brought to light in satisfactory ...
Dženan Kovačić +3 more
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Trained innate immunity, epigenetics, and food allergy
Frontiers in Allergy, 2023 In recent years the increased incidence of food allergy in Western culture has been associated with environmental factors and an inappropriate immune phenotype.
Llilian Arzola-Martínez +5 more
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