Results 51 to 60 of about 61,594 (230)

Immune Training Unlocks Innate Potential [PDF]

Cell, 2018
Trained immunity is a form of innate immune memory with distinct features from classical adaptive immune memory. In the current issues of Cell and Cell Host & Microbe, five studies from the International Trained Immunity Consortium shed light on mechanisms and functional consequences of this phenomenon on cellular and whole-organism levels.
Wilbur M, Song, Marco, Colonna
openaire   +2 more sources

Innate Immune Pathways in Atherosclerosis—From Signaling to Long-Term Epigenetic Reprogramming

Cells, 2023
Innate immune pathways play a crucial role in the development of atherosclerosis, from sensing initial danger signals to the long-term reprogramming of immune cells.
Arailym Aronova, Federica Tosato, Nawraa Naser, Yaw Asare   +3 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes

The Journal of Clinical Investigation, 2022
Trained immunity refers to the long-lasting memory traits of innate immunity. Recent studies have shown that trained immunity is orchestrated by sustained changes in epigenetic marks and metabolic pathways, leading to an altered transcriptional response ...
Bowen Zhang, Simone J.C.F.M Moorlag, Jorge Dominguez-Andres, Özlem Bulut, Gizem Kilic, Zhaoli Liu, Reinout van Crevel, Cheng-Jian Xu, Leo A.B. Joosten, Mihai G. Netea, Yang Li   +10 more
doaj   +1 more source

Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections

Journal for ImmunoTherapy of Cancer, 2023
Background BCG is recommended as intravesical immunotherapy to reduce the risk of tumor recurrence in patients with non-muscle invasive bladder cancer (NMIBC). Currently, it is unknown whether intravesical BCG application induces trained immunity.Methods
J Alfred Witjes, Alina Vrieling, Mihai G Netea, Leo A B Joosten, Katja K H Aben, Sita H Vermeulen, Joost L Boormans, Antoine G van der Heijden, Boris Novakovic, Jelmer H van Puffelen, Liesbeth van Emst, Denise Kooper, Tahlita C M Zuiverloon, Ursula T H Oldenhof, Tessel E Galesloot, Lambertus A L M Kiemeney, Egbert Oosterwijk   +16 more
doaj   +1 more source

Trained Immunity: Reprogramming Innate Immunity in Health and Disease

Annual Review of Immunology, 2021
Traditionally, the innate and adaptive immune systems are differentiated by their specificity and memory capacity. In recent years, however, this paradigm has shifted: Cells of the innate immune system appear to be able to gain memory characteristics after transient stimulation, resulting in an enhanced response upon secondary challenge.
Bekkering, S., Dominguez Andres, J., Joosten, L.A.B., Joosten, L.A.B., Riksen, N.P., Netea, M.G.   +5 more
openaire   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Trained Immunity and its Role in Health and Diseases: A Review [PDF]

Indian Journal of Medical Biochemistry
The term immunity mostly refers to adaptive immunity, even though innate immunity also plays a crucial role. Immunological memory is the key feature distinguishing adaptive immunity from innate immunity.
Santosh Kumar Gupta
doaj   +1 more source

EZH2 identifies the precursors of human natural killer cells with trained immunity

Cancer Biology & Medicine, 2021
Objective: Trained immunity of natural killer (NK) cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation.
Chen Zhang, Jie Yin, Jian Zheng, Jun Xiao, Jiajian Hu, Yudong Su, Kaichen Zhou, Yingchi Zhang, Xuzhen Zhang, Hong Zhang, Qian Sun, Yang Wang, Wenwen Yu, Feng Wei, Qiang Zhao, Long Li, Xiubao Ren   +16 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source