Results 21 to 30 of about 3,929,670 (363)
Distinct changes in endosomal composition promote NLRP3 inflammasome activation
Nature Immunology, 2022 A dogma in the inflammasome field is that NLRP3 activation occurs at dispersed vesicles of the trans -Golgi network. Here, Ricci and colleagues find that these vesicles are of endosomal origin and that endosomes comprise the compartment where NLRP3 is ...
Zhirong Zhang +8 more
semanticscholar +1 more source
Cis and trans effects differentially contribute to the evolution of promoters and enhancers
Genome Biology, 2020 Background Gene expression differences between species are driven by both cis and trans effects. Whereas cis effects are caused by genetic variants located on the same DNA molecule as the target gene, trans effects are due to genetic variants that affect
Kaia Mattioli +6 more
doaj +1 more source
PLoS ONE, 2020 Chromatin structure plays a decisive role in gene regulation through the actions of transcriptional activators, coactivators, and epigenetic machinery.
Michelle Esposito +5 more
doaj +1 more source
Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. [PDF]
PLoS ONE, 2015 Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways.
Hana Moon +8 more
doaj +1 more source
trans-Activation of a globin promoter in nonerythroid cells. [PDF]
Molecular and Cellular Biology, 1991 We show that expression in fibroblasts of a single cDNA, encoding the erythroid DNA-binding protein Eryf1 (GF-1, NF-E1), very efficiently activates transcription of a chicken alpha-globin promoter, trans-Activation in these cells occurred when Eryf1 bound to a single site within a minimal globin promoter.
Gary Felsenfeld, Todd Evans
openaire +3 more sources
Articulations and controversies in sex-work trans-activism [PDF]
Critical Social Policy, 2020 Beatriz Espejo has worked in Barcelona as a trans-sex-worker since the 1980s, and in 1993 she founded the CTC, one of the leading activist organisations in the Spanish trans movement during the ’00s. The CTC had a direct impact on the definition of the Spanish law on gender identity.
Beatriz Espejo +2 more
openaire +2 more sources
mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy
Nature Communications, 2023 Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression.
Lisa Maria Riedmayr +20 more
doaj +1 more source
Introduction: Affective Histories of Queer and Trans Activism
SQS – Suomen Queer-tutkimuksen Seuran lehti, 2023 Non peer ...
Alasuutari, Varpu +4 more
openaire +3 more sources
Programmable RNA detection with CRISPR-Cas12a
Nature Communications, 2023 Cas12a, a CRISPR-associated protein complex, has an inherent ability to cleave DNA substrates and is utilized in diagnostic tools to identify DNA molecules. We demonstrate that multiple orthologs of Cas12a activate trans-cleavage in the presence of split
Santosh R. Rananaware +8 more
doaj +1 more source
Gene activation by a CRISPR-assisted trans enhancer
eLife, 2019 The deactivated CRISPR/Cas9 (dCas9) is now the most widely used gene activator. However, current dCas9-based gene activators are still limited by their unsatisfactory activity.
Xinhui Xu +5 more
doaj +1 more source