A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5'UTRs of Selected Tumor Suppressors. [PDF]
PLoS ONE, 2016 BACKGROUND:Translational control is a mechanism of protein synthesis regulation emerging as an important target for new therapeutics. Naturally occurring microRNAs and synthetic small inhibitory RNAs (siRNAs) are the most recognized regulatory molecules ...
Adam Master +5 more
doaj +1 more source
Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. [PDF]
, 2002 Signal transducer and activator of transcription 3 (STAT3) transcription factors are cytoplasmic proteins that induce gene activation in response to cytokine receptor stimulation.
D.M. Heery +5 more
core +2 more sources
An emerging and variant viral promoter of HIV-1 subtype C exhibits low-level gene expression noise
Retrovirology, 2021 Background We observe the emergence of several promoter-variant viral strains in India during recent years. The variant viral promoters contain additional copies of transcription factor binding sites present in the viral modulatory region or enhancer ...
Haider Ali +7 more
doaj +1 more source
The cAMP Inducers Modify N-Acetylaspartate Metabolism in Wistar Rat Brain
Antioxidants, 2021 Neuronal N-acetylaspartate production appears in the presence of aspartate N-acetyltransferase (NAT8L) and binds acetyl groups from acetyl-CoA with aspartic acid.
Robert Kowalski +5 more
doaj +1 more source
Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements [PDF]
, 1988 The recent discovery that the activation domains of transcriptional activators (e.g., GAL4) from a number of species are interchangeable has led to the concept of a general mechanism for activation of RNA polymerase II genes.
Grossniklaus, U. +3 more
core +1 more source
A trans-activator-like structure in RCNMV RNA1 evokes the origin of the trans-activator in RNA2
PLOS Pathogens, 2020 The Red clover necrotic mosaic virus (RCNMV) genome consists of two plus-strand RNA genome segments, RNA1 and RNA2. RNA2 contains a multifunctional RNA structure known as the trans-activator (TA) that (i) promotes subgenomic mRNA transcription from RNA1, (ii) facilitates replication of RNA2, and (iii) mediates particle assembly and copackaging of ...
Laura R. Newburn, K. Andrew White
openaire +4 more sources
The molecular basis for stability of heterochromatin-mediated silencing in mammals. [PDF]
, 2009 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Festenstein, Richard +5 more
core +4 more sources
Bioassay for trans-activation using purified human immunodeficiency virus tat-encoded protein: trans-activation requires mRNA synthesis. [PDF]
Proceedings of the National Academy of Sciences, 1989 Expression of the human immunodeficiency virus tat-encoded protein (Tat) is required for virus replication. A genetic approach was used to facilitate the purification of biologically active Tat. A recombinant Tat protein containing a stretch of six histidine residues and a protease cleavage site was engineered and purified to greater than 95 ...
R, Gentz, C H, Chen, C A, Rosen
openaire +2 more sources
Cross regulation of sirtuin 1, AMPK, and PPARγ in conjugated linoleic acid treated adipocytes. [PDF]
PLoS ONE, 2012 Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) reduces triglyceride (TG) levels in adipocytes through multiple pathways, with AMP-activated protein kinase (AMPK) generally facilitating, and peroxisome proliferator-activated receptor γ (PPARγ ...
Shan Jiang +3 more
doaj +1 more source
Cell-Cycle Dependence of Transcription Dominates Noise in Gene Expression [PDF]
, 2013 The large variability in mRNA and protein levels found from both static and dynamic measurements in single cells has been largely attributed to random periods of transcription, often occurring in bursts.
A Bar-Even +72 more
core +4 more sources