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Optimization of Transcription Factor Genetic Circuits
Biology, 2022 Transcription factors (TFs) affect the production of mRNAs. In essence, the TFs form a large computational network that controls many aspects of cellular function. This article introduces a computational method to optimize TF networks. The method extends
Steven A. Frank
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Transcription Factor-Based Genetic Engineering in Microalgae [PDF]
Plants, 2021 Sequence-specific DNA-binding transcription factors (TFs) are key components of gene regulatory networks. Advances in high-throughput sequencing have facilitated the rapid acquisition of whole genome assembly and TF repertoires in microalgal species.
Keiichi Mochdia, Shun Tamaki
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Transcriptional programming using engineered systems of transcription factors and genetic architectures [PDF]
Nature Communications, 2019 The control of gene expression is an important tool for metabolic engineering, the design of synthetic gene networks, and protein manufacturing. The most successful approaches to date are based on modulating mRNA synthesis via an inducible coupling to ...
Ronald E Rondon +3 more
semanticscholar +4 more sources
Genetic and Epigenetic Regulation of CCR5 Transcription [PDF]
Biology, 2012 The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature dendritic cells) and microglia.
Rutger J. Wierda, Peter J. van den Elsen
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The role of input noise in transcriptional regulation [PDF]
PLoS ONE 3: e2774 (2008), 2006 Even under constant external conditions, the expression levels of genes fluctuate. Much emphasis has been placed on the components of this noise that are due to randomness in transcription and translation; here we analyze the role of noise associated with the inputs to transcriptional regulation, the random arrival and binding of transcription factors ...
A Bar–Even +46 more
arxiv +6 more sources
Genetic Architecture of Transcription and Chromatin Regulation [PDF]
Genomics & Informatics, 2015 DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures.
Kwoneel Kim +3 more
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Genetic and epigenomic mechanisms of mammalian circadian transcription [PDF]
Nature Structural & Molecular Biology, 2016 The mammalian molecular clock comprises a complex network of transcriptional programs that integrates environmental signals with physiological pathways in a tissue-specific manner. Emerging technologies are extending knowledge of basic clock features by uncovering their underlying molecular mechanisms, thus setting the stage for a 'systems' view of the
R. Papazyan, Yuxiang Zhang, M. Lazar
semanticscholar +4 more sources
Transcription as a Threat to Genome Integrity [PDF]
Annual Review of Biochemistry, 2016 Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés +1 more
core +2 more sources
Identifying the genetic determinants of transcription factor activity
Molecular Systems Biology, 2010 Analysis of parallel genotyping and expression profiling data has shown that mRNA expression levels are highly heritable. Currently, only a tiny fraction of this genetic variance can be mechanistically accounted for.
Eunjee Lee, Harmen J Bussemaker
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Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism? [PDF]
Diabetes & Metabolism Journal, 2020 Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription ...
Hye-Sook Han +2 more
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