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Optimization of Transcription Factor Genetic Circuits
Biology, 2022 Transcription factors (TFs) affect the production of mRNAs. In essence, the TFs form a large computational network that controls many aspects of cellular function. This article introduces a computational method to optimize TF networks. The method extends
Steven A. Frank
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Transcription Factor-Based Genetic Engineering in Microalgae [PDF]
Plants, 2021 Sequence-specific DNA-binding transcription factors (TFs) are key components of gene regulatory networks. Advances in high-throughput sequencing have facilitated the rapid acquisition of whole genome assembly and TF repertoires in microalgal species.
Keiichi Mochdia, Shun Tamaki
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Genetic and Epigenetic Regulation of CCR5 Transcription [PDF]
Biology, 2012 The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature dendritic cells) and microglia.
Rutger J. Wierda, Peter J. van den Elsen
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Genetic Architecture of Transcription and Chromatin Regulation [PDF]
Genomics & Informatics, 2015 DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures.
Kwoneel Kim +3 more
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Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy
Medicine in Drug Discovery, 2022 PE and GDM are two major metabolic diseases affecting pregnancy. Individuals suffering from GDM are at an increased risk of developing PE in later gestational stages.
Nupur Rani Agarwal +3 more
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Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism? [PDF]
Diabetes & Metabolism Journal, 2020 Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription ...
Hye-Sook Han +2 more
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Molecules, 2022 An assemblage nexus of microorganisms enclosed in a composite extracellular polymeric matrix is called as a biofilm. The main factor causing biological fouling, or biofouling, is biofilms. Biofilm-mediated biofouling is a significant detrimental issue in
Anupam Patra +5 more
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Frontiers in Cell and Developmental Biology, 2023 The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova +12 more
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Genetic determinants of neuroglobin transcription [PDF]
neurogenetics, 2013 Neuroglobin (NGB) is a neuron-specific vertebrate globin shown to protect against hypoxia, ischemia, oxidative stress and the toxic effects of Amyloid-beta. Following on our and others' results highlighting the importance of NGB expression in disease, we searched for genetic determinants of its expression.
R, Wang +4 more
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Frontiers in Microbiology, 2020 (p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha +3 more
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