Results 51 to 60 of about 1,570,740 (185)

Correlation analysis of the transcriptome of growing leaves with mature leaf parameters in a maize RIL population [PDF]

, 2015
Background: To sustain the global requirements for food and renewable resources, unraveling the molecular networks underlying plant growth is becoming pivotal.
Baute, Joke, Coppens, Frederik, De Block, Jolien, Dell'Acqua, Matteo, Herman, Dorota, Inzé, Dirk, Maere, Steven, Nelissen, Hilde, Pè, Mario Enrico, Slabbinck, Bram   +9 more
core   +2 more sources

Genetic dissection of the RNA polymerase II transcription cycle

eLife, 2022
How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during transcription remains poorly understood. Here, we used naturally occurring genetic variation in F1 hybrid mice to explore how DNA sequence differences affect the ...
Shao-Pei Chou, Adriana K Alexander, Edward J Rice, Lauren A Choate, Charles G Danko   +4 more
doaj   +1 more source

Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease [PDF]

, 2019
Differences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors
Nowick, Katja, Perdomo-Sabogal, Álvaro
core   +1 more source

Epistatic relationships reveal the functional organization of yeast transcription factors

Molecular Systems Biology, 2010
The regulation of gene expression is, in large part, mediated by interplay between the general transcription factors (GTFs) that function to bring about the expression of many genes and site‐specific DNA‐binding transcription factors (STFs).
Jiashun Zheng, Joris J Benschop, Michael Shales, Patrick Kemmeren, Jack Greenblatt, Gerard Cagney, Frank Holstege, Hao Li, Nevan J Krogan   +8 more
doaj   +1 more source

The evolution of complex gene regulation by low specificity binding sites

, 2012
Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost ...
Plotkin, Joshua B., Stewart, Alexander J.   +1 more
core   +1 more source

Using network component analysis to dissect regulatory networks mediated by transcription factors in yeast.

PLoS Computational Biology, 2009
Understanding the relationship between genetic variation and gene expression is a central question in genetics. With the availability of data from high-throughput technologies such as ChIP-Chip, expression, and genotyping arrays, we can begin to not only
Chun Ye, Simon J Galbraith, James C Liao, Eleazar Eskin   +3 more
doaj   +1 more source

The 5' untranslated region of the I factor, a long interspersed nuclear element-like retrotransposon of Drosophila melanogaster, contains an internal promoter and sequences that regulate expression [PDF]

, 1993
The I-R system of hybrid dysgenesis in Drosophila melanogaster is controlled by a long interspersed nuclear element-like retroposon, the I factor.
BUCHETON, A, FINNEGAN, D J, Finnegan, David, MCLEAN, C   +3 more
core   +1 more source

The Magnitude of Dyslipidemia and Factors Associated with Elevated LDL-C Among Black South Africans with Type 2 Diabetes Mellitus at a Tertiary Hospital

Obesities
Background/Objectives: Type 2 diabetes mellitus (T2DM) is a major global public health challenge with a significant impact on human life. The current study aims to provide a comprehensive analysis of the magnitude of dyslipidemia and the factors ...
Mashudu Nemukula, Siphesihle Mkhwanazi, Tumelo Jessica Mapheto, Arun Kumar Malaisamy, Neel Sarovar Bhavesh, Olebogeng Harold Majane, Sechene Stanley Gololo   +6 more
doaj   +1 more source

Probing marine macroalgal phlorotannins as an antibacterial candidate against Salmonella typhi: Molecular docking and dynamics simulation approach

Current Plant Biology
The increasing prevalence of drug-resistant bacterial strains, including multidrug-resistant Salmonella typhi, has raised significant concerns about the effectiveness of traditional antimicrobial treatments.
Arun Kumar Malaisamy, Balamuralikrishnan Balasubramanian, Pon Yazhine Tamilselvan, Venkatesh Sakthivel, Santhi Venkatachalapathi, Haripriya Kuchi Bhotla   +5 more
doaj   +1 more source

Many ways to break a heart

eLife, 2015
A mutant transcription factor that has been linked to congenital heart disease has wider effects than previously thought.
Megan Rowton, Ivan P Moskowitz
doaj   +1 more source