Results 11 to 20 of about 2,190,849 (297)

Transcriptional regulation of haematopoietic transcription factors [PDF]

open access: yesStem Cell Research & Therapy, 2011
The control of differential gene expression is central to all metazoan biology. Haematopoiesis represents one of the best understood developmental systems where multipotent blood stem cells give rise to a range of phenotypically distinct mature cell types, all characterised by their own distinctive gene expression profiles.
Wilson, Nicola K   +3 more
openaire   +2 more sources

Structural Analysis of (p)ppGpp Reveals Its Versatile Binding Pattern for Diverse Types of Target Proteins

open access: yesFrontiers in Microbiology, 2020
(p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha   +3 more
doaj   +1 more source

Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy

open access: yesMedicine in Drug Discovery, 2022
PE and GDM are two major metabolic diseases affecting pregnancy. Individuals suffering from GDM are at an increased risk of developing PE in later gestational stages.
Nupur Rani Agarwal   +3 more
doaj   +1 more source

Transcriptional Activation: Tuning-up transcription [PDF]

open access: yesCurrent Biology, 1995
Eukaryotic transcription is a complex process, and recent results identify multiple steps that need to be stimulated to activate transcription, one of which is a change in conformation of the general transcription factor TFIIB.
Sheldon, Michael, Danny, Reinberg
openaire   +2 more sources

A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

open access: yesFrontiers in Cell and Developmental Biology, 2023
The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova   +12 more
doaj   +1 more source

Transcription and post-transcriptional regulation of spermatogenesis [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2010
Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards
Anilkumar, Bettegowda   +1 more
openaire   +2 more sources

Rho-dependent transcription termination in bacteria recycles RNA polymerases stalled at DNA lesions

open access: yesNature Communications, 2019
In bacteria, the Rho protein dislodges elongation complexes to terminate transcription, and the Mfd protein removes RNA polymerases (RNAPs) stalled at DNA lesions. Here, Jain et al.
Sriyans Jain, Richa Gupta, Ranjan Sen
doaj   +1 more source

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

open access: yeseLife, 2016
The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear ...
Richard Panayiotou   +6 more
doaj   +1 more source

The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms

open access: yesBiology Open, 2020
The mammalian PBAF subfamily of SWI/SNF chromatin remodeling complexes plays a wide role in the regulation of gene expression. PHF10 is a subunit of the signature module of PBAF, responsible for its interaction with chromatin.
Andrey A. Sheynov   +5 more
doaj   +1 more source

N-Terminus Plays a Critical Role for Stabilizing the Filamentous Assembly and the Antifungal Activity of Bg_9562

open access: yesMicrobiology Spectrum, 2022
Bg_9562, a prophage tail-like protein was earlier shown to be required for bacterial mycophagy by Burkholderia gladioli strain NGJ1. The purified protein exhibited broad-spectrum antifungal activity; however, the structural and mechanistic details vis-à ...
Pankaj Kumar Sahoo   +5 more
doaj   +1 more source

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