Results 11 to 20 of about 3,171,731 (365)
Transcriptional and Post-Transcriptional Regulation of Autophagy [PDF]
Cells, 2022 Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways.
Qiuqin Ma +5 more
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Repressive Transcription [PDF]
Science, 2010 Chromatin repression is ironically controlled by the initiation of transcription at specific sites in the genome.
Young, Richard A., Guenther, Matthew
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Boosting transcription by transcription: enhancer-associated transcripts [PDF]
Chromosome Research, 2013 Enhancers are traditionally viewed as DNA sequences located some distance from a promoter that act in cis and in an orientation-independent fashion to increase utilization of specific promoters and thereby regulate gene expression. Much progress has been made over the last decade toward understanding how these distant elements interact with target ...
Emily M. Darrow, Brian P. Chadwick
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Dynamics of transcriptional and post-transcriptional regulation [PDF]
Briefings in Bioinformatics, 2020 AbstractDespite gene expression programs being notoriously complex, RNA abundance is usually assumed as a proxy for transcriptional activity. Recently developed approaches, able to disentangle transcriptional and post-transcriptional regulatory processes, have revealed a more complex scenario.
Furlan M, De Pretis S, Pelizzola M
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NRF2, a Transcription Factor for Stress Response and Beyond
International Journal of Molecular Sciences, 2020 Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.
Feng He, Xiaoli Ru, T. Wen
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Transcriptional Activation: Tuning-up transcription [PDF]
Current Biology, 1995 Eukaryotic transcription is a complex process, and recent results identify multiple steps that need to be stimulated to activate transcription, one of which is a change in conformation of the general transcription factor TFIIB.
Reinberg Danny, Michael Sheldon
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Nucleic Acids Research, 1983 We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters.
J. Dignam, R. Lebovitz, R. Roeder
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Landscape of transcription in human cells
Nature, 2012 Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations ...
S. Djebali +84 more
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The Dangers of Transcription [PDF]
Cell, 2009 Transcription is obviously essential, but even a good thing can be dangerous at times. In this issue, Lin et al. (2009) provide evidence that binding of the transcription machinery may predispose genome regions to breakage and translocations that may lead to cancer.
Tom Misteli, Stephan Mathas
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Journal of Molecular Endocrinology, 2000 The reverse transcription polymerase chain reaction (RT-PCR) is the most sensitive method for the detection of low-abundance mRNA, often obtained from limited tissue samples.
S. Bustin
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