Results 21 to 30 of about 2,206,258 (297)
Frontiers in Microbiology, 2020 One of the major ways of acquiring multidrug resistance in bacteria is via drug influx and efflux pathways. Here, we show that E. coli with compromised Rho-dependent transcription termination function has enhanced broad-spectrum antibiotic susceptibility,
Md. Hafeezunnisa +2 more
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Many Distinct Ways Lead to Drug Resistance in BRAF- and NRAS-Mutated Melanomas
Life, 2021 Advanced melanoma is a relentless tumor with a high metastatic potential. The combat of melanoma by using the targeted therapy is impeded because several major driver mutations fuel its growth (predominantly BRAF and NRAS).
Jiri Vachtenheim, Lubica Ondrušová
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BMC Molecular and Cell Biology, 2020 Background G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological role of G-quadruplexes have not been
Shivani Kumar +4 more
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Genome Biology, 2013 A newly demonstrated defect in RNA polymerase II termination caused by 7SK snRNA knockdown may have revealed a novel mechanism uncoupling RNA processing from transcription.
Guo, Jiannan +2 more
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Transcription Factors Modulate c-Fos Transcriptional Bursts
Cell Reports, 2014 Transcription is a stochastic process occurring mostly in episodic bursts. Although the local chromatin environment is known to influence the bursting behavior on long timescales, the impact of transcription factors (TFs)—especially in rapidly inducible ...
Adrien Senecal +7 more
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Transcriptional regulation [PDF]
WormBook, 2005 The regulation of transcription in C. elegans shares many similarities to transcription in other organisms. The details of how specific transcription factors bind to target promoters and act as either activators or repressors are still being examined in many cases, but an increasing number of factors and their binding sites are being characterized ...
Peter G, Okkema, Michael, Krause
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Transcription, 2020 Increasingly sophisticated biochemical and genetic techniques are unraveling the regulatory factors and mechanisms that control gene expression in the Archaea. While some similarities in regulatory strategies are universal, archaeal-specific regulatory strategies are emerging to complement a complex patchwork of shared archaeal-bacterial and archaeal ...
Breanna R. Wenck, Thomas J. Santangelo
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Nature CommunicationsParacrine IL-2 signalling drives the CD8 + T cell expansion and differentiation that allow protection against viral infections, but the underlying molecular events are incompletely understood.
Diane Maurice +5 more
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Cell Reports, 2019 Summary: Despite substantial progress in our understanding of the players involved and the regulatory mechanisms controlling the initiation and elongation steps of transcription, little is known about the recruitment of elongation factors at promoter ...
Dipika Yadav +4 more
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ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes
Nature Communications, 2023 The function of the mitogen-activated protein kinase signaling pathway is required for the activation of immediate early genes (IEGs), including EGR1 and FOS, for cell growth and proliferation.
Heeyoun Bunch +10 more
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