Results 21 to 30 of about 3,171,731 (365)

Transcriptional regulation of haematopoietic transcription factors [PDF]

Stem Cell Research & Therapy, 2011
The control of differential gene expression is central to all metazoan biology. Haematopoiesis represents one of the best understood developmental systems where multipotent blood stem cells give rise to a range of phenotypically distinct mature cell types, all characterised by their own distinctive gene expression profiles.
Berthold Göttgens, Nicola K. Wilson, Fernando J Calero-Nieto, Rita Ferreira   +3 more
openaire   +2 more sources

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer

Frontiers in Immunology, 2019
Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL.
Abel H. Y. Tan, WenJuan Tu, Robert McCuaig, Kristine Hardy, Thomasina Donovan, Sofiya Tsimbalyuk, Jade K. Forwood, Sudha Rao   +7 more
doaj   +1 more source

The Role of the Histone Variant H2A.Z in Metazoan Development

Journal of Developmental Biology, 2022
During the emergence and radiation of complex multicellular eukaryotes from unicellular ancestors, transcriptional systems evolved by becoming more complex to provide the basis for this morphological diversity.
Yasmin Dijkwel, David J. Tremethick
doaj   +1 more source

Transcriptional enhancers: Transcription, function and flexibility [PDF]

Transcription, 2016
Active transcriptional enhancers are often transcribed to eRNAs, whose changing levels mirror those of the target gene mRNA. We discuss some of the reported functions of these eRNAs and their likely diversity to allow utilization of distinct cis regulatory regions to enhance transcription in diverse developmental and cellular contexts.
Sergei Rudnizky, Yahav Yosefzon, Lilach Pnueli, Philippa Melamed   +3 more
openaire   +3 more sources

The Rho-Dependent Transcription Termination Is Involved in Broad-Spectrum Antibiotic Susceptibility in Escherichia coli

Frontiers in Microbiology, 2020
One of the major ways of acquiring multidrug resistance in bacteria is via drug influx and efflux pathways. Here, we show that E. coli with compromised Rho-dependent transcription termination function has enhanced broad-spectrum antibiotic susceptibility,
Md. Hafeezunnisa, Md. Hafeezunnisa, Ranjan Sen   +2 more
doaj   +1 more source

Many Distinct Ways Lead to Drug Resistance in BRAF- and NRAS-Mutated Melanomas

Life, 2021
Advanced melanoma is a relentless tumor with a high metastatic potential. The combat of melanoma by using the targeted therapy is impeded because several major driver mutations fuel its growth (predominantly BRAF and NRAS).
Jiri Vachtenheim, Lubica Ondrušová
doaj   +1 more source

The Transcription Factor Encyclopedia [PDF]

Genome Biology, 2012
AbstractHere we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130 mini review articles on pertinent human, mouse and rat TFs.
Yusuf, Dimas, Butland, Stefanie L., Swanson, Magdalena I., Bolotin, Eugene, Ticoll, Amy, Cheung, Warren A., Zhang, Xiao Yu Cindy, Dickman, Christopher T. D., Fulton, Debra L., Lim, Jonathan S., Schnabl, Jake M., Ramos, Oscar H. P., Vasseur-Cognet, Mireille, de Leeuw, Charles N., Simpson, Elizabeth M., Ryffel, Gerhart U., Lam, Eric W.-F., Kist, Ralf, Wilson, Miranda S. C., Marco-Ferreres, Raquel, Brosens, Jan J., Beccari, Leonardo L., Bovolenta, Paola, Benayoun, Bérénice A., Monteiro, Lara J, Schwenen, Helma D C, Grontved, Lars, Wederell, Elizabeth, Mandrup, Susanne, Veitia, Reiner A, Chakravarthy, Harini, Hoodless, Pamela A., Mancarelli, M Michela, Torbett, Bruce E, Banham, Alison H, Reddy, Sekhar P, Cullum, Rebecca L, Liedtke, Michaela, Tschan, Mario P, Vaz, Michelle, Rizzino, Angie, Zannini, Mariastella, Frietze, Seth, Farnham, Peggy J, Eijkelenboom, Astrid, Brown, Philip J, Laperrière, David, Leprince, Dominique, de Cristofaro, Tiziana, Prince, Kelly L, Putker, Marrit, del Peso, Luis, Camenisch, Gieri, Wenger, Roland H, Mikula, Michal, Rozendaal, Marieke, Mader, Sylvie, Ostrowski, Jerzy, Rhodes, Simon J, Van Rechem, Capucine, Boulay, Gaylor, Olechnowicz, Sam W Z, Breslin, Mary B, Lan, Michael S, Nanan, Kyster K, Wegner, Michael, Hou, Juan, Mullen, Rachel D, Colvin, Stephanie C, Noy, Peter John, Webb, Carol F, Witek, Matthew E, Ferrell, Scott, Daniel, Juliet M, Park, Jason, Waldman, Scott A, Peet, Daniel J, Taggart, Michael, Jayaraman, Padma-Sheela, Karrich, Julien J, Blom, Bianca, Vesuna, Farhad, O'Geen, Henriette, Sun, Yunfu, Gronostajski, Richard M, Woodcroft, Mark W, Hough, Margaret R, Chen, Edwin, Europe-Finner, G Nicholas, Karolczak-Bayatti, Magdalena, Bailey, Jarrod, Hankinson, Oliver, Raman, Venu, LeBrun, David P, Biswal, Shyam, Harvey, Christopher J, DeBruyne, Jason P, Hogenesch, John B, Hevner, Robert F, Héligon, Christophe, Luo, Xin M, Blank, Marissa Cathleen, Millen, Kathleen Joyce, Sharlin, David S, Forrest, Douglas, Dahlman-Wright, Karin, Zhao, Chunyan, Mishima, Yuriko, Sinha, Satrajit, Chakrabarti, Rumela, Portales-Casamar, Elodie, Sladek, Frances M, Bradley, Philip H, Wasserman, Wyeth W, Cindy Zhang, Xiao   +114 more
openaire   +14 more sources

PlantTFDB 4.0: toward a central hub for transcription factors and regulatory interactions in plants

Nucleic Acids Res., 2016
With the goal of providing a comprehensive, high-quality resource for both plant transcription factors (TFs) and their regulatory interactions with target genes, we upgraded plant TF database PlantTFDB to version 4.0 (http://planttfdb.cbi.pku.edu.cn ...
Jinpu Jin, Feng Tian, Dechang Yang, Yuqi Meng, Lei Kong, Jingchu Luo, Ge Gao   +6 more
semanticscholar   +1 more source

Transcription Activation via Transcriptional Bursting [PDF]

Biophysical Journal, 2011
Transcription factors (TFs) often regulate their own expression; monitoring TF production in real time will help elucidate autoregulatory mechanisms. However, many TFs are expressed at low levels and are difficult to detect. Further, labeling TFs with fluorescent proteins risks disrupting their regulatory functions. Here, we report a novel strategy, Co-
Jin Wang, Haidong Feng, Zach Hensel, Bo Han, Jie Xiao, Xuefang Liu, Christine L. Hatem   +6 more
openaire   +2 more sources

Analysis of G-quadruplexes upstream of herpesvirus miRNAs: evidence of G-quadruplex mediated regulation of KSHV miR-K12–1-9,11 cluster and HCMV miR-US33

BMC Molecular and Cell Biology, 2020
Background G-quadruplexes regulate gene expression, recombination, packaging and latency in herpesviruses. Herpesvirus-encoded miRNAs have been linked to important biological functions. The presence and the biological role of G-quadruplexes have not been
Shivani Kumar, Divya Choudhary, Anupam Patra, Neel Sarovar Bhavesh, Perumal Vivekanandan   +4 more
doaj   +1 more source