Results 21 to 30 of about 3,372,915 (384)
Frontiers in Immunology, 2019 Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL.
Abel H. Y. Tan +7 more
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Transcription-associated mutation promotes RNA complexity in highly expressed genes - a major new source of selectable variation [PDF]
, 2018 Alternatively spliced transcript isoforms are thought to play a critical role for functional diversity. However, the mechanism generating the enormous diversity of spliced transcript isoforms remains unknown, and its biological significance remains ...
Bruford, Michael W. +9 more
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Transcriptional regulation of haematopoietic transcription factors [PDF]
Stem Cell Research & Therapy, 2011 The control of differential gene expression is central to all metazoan biology. Haematopoiesis represents one of the best understood developmental systems where multipotent blood stem cells give rise to a range of phenotypically distinct mature cell types, all characterised by their own distinctive gene expression profiles.
Berthold Göttgens +3 more
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Rho-dependent transcription termination in bacteria recycles RNA polymerases stalled at DNA lesions
Nature Communications, 2019 In bacteria, the Rho protein dislodges elongation complexes to terminate transcription, and the Mfd protein removes RNA polymerases (RNAPs) stalled at DNA lesions. Here, Jain et al.
Sriyans Jain, Richa Gupta, Ranjan Sen
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In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]
, 2015 Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana +9 more
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Divergent transcription is associated with promoters of transcriptional regulators [PDF]
BMC Genomics, 2013 Divergent transcription is a wide-spread phenomenon in mammals. For instance, short bidirectional transcripts are a hallmark of active promoters, while longer transcripts can be detected antisense from active genes in conditions where the RNA degradation machinery is inhibited.
Hélène Holota +27 more
openaire +6 more sources
The Role of the Histone Variant H2A.Z in Metazoan Development
Journal of Developmental Biology, 2022 During the emergence and radiation of complex multicellular eukaryotes from unicellular ancestors, transcriptional systems evolved by becoming more complex to provide the basis for this morphological diversity.
Yasmin Dijkwel, David J. Tremethick
doaj +1 more source
Transcriptional Regulation: a Genomic Overview [PDF]
, 2002 The availability of the Arabidopsis thaliana genome sequence allows a comprehensive analysis of transcriptional regulation in plants using novel genomic approaches and methodologies. Such a genomic view of transcription first necessitates the compilation
Riechmann, José Luis
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Many Distinct Ways Lead to Drug Resistance in BRAF- and NRAS-Mutated Melanomas
Life, 2021 Advanced melanoma is a relentless tumor with a high metastatic potential. The combat of melanoma by using the targeted therapy is impeded because several major driver mutations fuel its growth (predominantly BRAF and NRAS).
Jiri Vachtenheim, Lubica Ondrušová
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Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]
, 2018 The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Georgieva, Sofia +6 more
core +1 more source