Results 61 to 70 of about 3,535,290 (383)

Transcription and post-transcriptional regulation of spermatogenesis [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2010
Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards
Anilkumar Bettegowda, Miles F. Wilkinson
openaire   +3 more sources

Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity [PDF]

, 2012
T cell development comprises a stepwise process of commitment from a multipotent precursor. To define molecular mechanisms controlling this progression, we probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide
Mortazavi, Ali, Rothenberg, Ellen V., Williams, Brian A., Wold, Barbara J., Zhang, Jingli A.   +4 more
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

eLife, 2014
Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture.
Ignacio Izeddin, Vincent Récamier, Lana Bosanac, Ibrahim I Cissé, Lydia Boudarene, Claire Dugast-Darzacq, Florence Proux, Olivier Bénichou, Raphaël Voituriez, Olivier Bensaude, Maxime Dahan, Xavier Darzacq   +11 more
doaj   +1 more source

Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration

Stem Cell Research & Therapy, 2023
Background Human multilineage-differentiating stress enduring (Muse) cells are nontumorigenic endogenous pluripotent-like stem cells that can be easily obtained from various adult or fetal tissues.
Honorine Dushime, Stéphanie G. Moreno, Christine Linard, Annie Adrait, Yohann Couté, Juliette Peltzer, Sébastien Messiaen, Claire Torres, Lydia Bensemmane, Daniel Lewandowski, Paul-Henri Romeo, Vanessa Petit, Nathalie Gault   +12 more
doaj   +1 more source

Improving Noise Robustness for Spoken Content Retrieval using Semi-supervised ASR and N-best Transcripts for BERT-based Ranking Models [PDF]

arXiv, 2023
BERT-based re-ranking and dense retrieval (DR) systems have been shown to improve search effectiveness for spoken content retrieval (SCR). However, both methods can still show a reduction in effectiveness when using ASR transcripts in comparison to accurate manual transcripts.
arxiv  

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Transcription of toll-like receptors 2, 3, 4 and 9, FoxP3 and Th17 cytokines in a susceptible experimental model of canine Leishmania infantum infection [PDF]

, 2015
Canine leishmaniosis (CanL) due to Leishmania infantum is a chronic zoonotic systemic disease resulting from complex interactions between protozoa and the canine immune system.
A Ives, A Rodriguez, A Rodriguez-Cortes, A Rodriguez-Cortes, A Rodriguez-Cortes, AB Reis, AK House, AK Rai, Alhelí Rodríguez-Cortés, AM Elassad, BL Travi, C Gallego, C Gonzalez-Lombana, C Maia, C Maia, C Riera, CE O'Neil, CF Alves, CR Engwerda, D Menezes-Souza, D Sacks, D Strauss-Ayali, DA Vargas-Inchaustegui, Damer P. Blake, E Bourreau, F Chappuis, FF Tuon, FF Tuon, G Baneth, GA Cezario, GD Melo, GK Katara, GM Santos-Gomes, H Kumar, IR Peters, J Alvar, J Liese, J Moreno, J Sano, JF Flandin, JM Ehrchen, Jordi Alberola, K Ghosh, K Wolk, Karin Allenspach, KL Silva, L Solano-Gallego, L Solano-Gallego, Laia Solano-Gallego, LM Melo, LP Carvalho, MA Almeida, MG Pitta, MJ de Veer, MJ Rica-Capela, MM Figueiredo, MM Figueiredo, MS Nascimento, N Peters, O Courtenay, O Francino, OA Garden, OR Rodrigues, P Desjeux, P Holzmuller, P Kropf, R Kumar, S Lopez Kostka, S Nylen, S Schmitz, S Tiwananthagorn, S Tolouei, SH Wood, Shazia Hosein, T Korn, TM Castilho, VL da Matta, VS Boaventura, VS Raman, Y Belkaid, Yara M. Traub-Csekö, ZK Peng   +81 more
core   +4 more sources

Human Transcription Quality Improvement [PDF]

INTERSPEECH 2023, 2023
High quality transcription data is crucial for training automatic speech recognition (ASR) systems. However, the existing industry-level data collection pipelines are expensive to researchers, while the quality of crowdsourced transcription is low. In this paper, we propose a reliable method to collect speech transcriptions. We introduce two mechanisms
arxiv  

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source