The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke [PDF]
Cell Death and Disease, 2021 Remote limb ischemic postconditioning (RLIP) is an experimental strategy in which short femoral artery ischemia reduces brain damage induced by a previous harmful ischemic insult.
Valeria Valsecchi +6 more
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Genomic Redistribution of Metal-Response Transcription Factor-1 (MTF-1) in Cadmium Resistant Cells [PDF]
Cells, 2023 (1) Background: Metal homeostasis is an important part of cellular programs and is disrupted when cells are exposed to carcinogenic heavy metals. Metal response is mediated by the metal response element transcription factor MTF-1.
Gregory M. Wright, Joshua C. Black
doaj +4 more sources
A T > G Mutation in the NR5A2 Gene Is Associated With Litter Size in Hu Sheep Through Upregulation of Promoter Activity by Transcription Factor MTF-1 [PDF]
Frontiers in Genetics, 2019 Nuclear receptor subfamily 5 group A member 2 (NR5A2), also referred to as LRH-1 or FTF, is an orphan nuclear hormone receptor that is involved in regulating embryonic development, ovarian granulosa cell differentiation, gonadal sex differentiation, and ...
Yinxia Li +13 more
doaj +3 more sources
The "metal transcription factor" MTF-1: biological facts and medical implications
Swiss Medical Weekly, 2001 Metallothioneins (MTs) are a class of small, cysteine-rich proteins that have an important function in heavy metal metabolism and detoxification and in the management of various forms of cell stress. Several lines of evidence suggest a role for metallothioneins in therapy resistance of malignant tumours, regulation of blood pressure and protection ...
P Lichtlen, W Schaffner
doaj +4 more sources
The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1). [PDF]
Mol Cell Biol, 2011 The gene for Parkin, an E3 ubiquitin ligase, is mutated in some familial forms of Parkinson's disease, a severe neurodegenerative disorder. A homozygous mutant of the Drosophila ortholog of human parkin is viable but results in severe motoric impairment including an inability to fly, female and male sterility, and a decreased life span.
Saini N, Georgiev O, Schaffner W.
europepmc +5 more sources
Correction: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke [PDF]
Cell Death and Disease, 2023 Valeria Valsecchi +6 more
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Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level [PDF]
Acta Biochimica Polonica, 2015 Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways.
Agata Grzywacz +5 more
core +4 more sources
Molecular cloning of metal-responsive transcription factor-1 (MTF-1) and transcriptional responses to metal and heat stresses in Pacific abalone, Haliotis discus hannai [PDF]
Fisheries and Aquatic Sciences, 2017 Background Metal-responsive transcription factor-1 (MTF-1) is a key transcriptional regulator playing crucial roles in metal homeostasis and cellular adaptation to diverse oxidative stresses. In order to understand cellular pathways associated with metal
Sang Yoon Lee, Yoon Kwon Nam
doaj +2 more sources
Target gene search for the metal-responsive transcription factor MTF-1 [PDF]
Nucleic Acids Research, 2001 Activation of genes by heavy metals, notably zinc, cadmium and copper, depends on MTF-1, a unique zinc finger transcription factor conserved from insects to human. Knockout of MTF-1 in the mouse results in embryonic lethality due to liver decay, while knockout of its best characterized target genes, the stress-inducible metallothionein genes I and II ...
Peter Lichtlen
openalex +4 more sources
Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1. [PDF]
Mol Cell Biol, 2008 Herein, the mechanisms of transactivation of gene expression by mouse metal response element-binding transcription factor 1 (MTF-1) were investigated. Evidence obtained from coimmunoprecipitation assays revealed that exposure of the cells to zinc resulted in the rapid formation of a multiprotein complex containing MTF-1, the histone acetyltransferase ...
Li Y +4 more
europepmc +6 more sources