Nucleic Acids Research, 1994 Metallothioneins (MTs) are small cysteine-rich proteins that bind heavy metal ions such as zinc, cadmium and copper with high affinity, and have been functionally implicated in heavy metal detoxification and radical scavenging. Transcription of metallothioneins genes is induced by exposure of cells to heavy metals.
Enrico Brugnera +6 more
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Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. [PDF]
Metallomics, 2020 Jackson AC +6 more
europepmc +3 more sources
Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.
The EMBO Journal, 1993 Metallothioneins (MTs) are small cysteine-rich proteins whose structure is conserved from fungi to man. MTs strongly bind heavy metals, notably zinc, copper and cadmium. Upon exposure of cells to heavy metal and other adverse treatments, MT gene transcription is strongly enhanced.
Freddy Radtke +6 more
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Chewing loads alter TMJ metabolism and Zn homeostasis via PIEZO1/ TRPV4 [PDF]
Journal of Biological EngineeringThe biomechanical effects of bite forces on a temporomandibular joint within the craniofacial masticatory complex remain unclear. Herein, we will discuss the effect of recovering a hypofunctioning temporomandibular joint using normal bite forces ...
Yongmei Wang +6 more
doaj +2 more sources
Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes [PDF]
Genes & Development, 2005 From insects to mammals, metallothionein genes are induced in response to heavy metal load by the transcription factor MTF-1, which binds to short DNA sequence motifs, termed metal response elements (MREs). Here we describe a novel and seemingly paradoxical role for MTF-1 in Drosophila in that it also mediates transcriptional activation of Ctr1B, a ...
Anand Selvaraj +7 more
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The legless lizard Anguis fragilis (slow worm) has a potent metal-responsive transcription factor 1 (MTF-1) [PDF]
Biological Chemistry, 2014 Abstract The metal-responsive transcription factor-1 (MTF-1) is a key regulator of heavy metal homeostasis and detoxification. Here we characterize the first MTF-1 from a reptile, the slow worm Anguis fragilis. The slow worm, or blind worm, is a legless lizard also known for its long lifespan of up to several decades.
Oleg Georgiev +4 more
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Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1) [PDF]
Biochemistry and Cell Biology, 2011 Metal-responsive transcription factor-1 (MTF-1) is essential for the induction of genes encoding metallothionein by metals and hypoxia. Here, we studied the mechanism controlling the activation of MTF-1 by hypoxia. Hypoxia activation of Mt gene transcription is dependent on the presence of metal regulatory elements (MREs) in the promoter of Mt genes ...
Annie Dubé +3 more
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Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison [PDF]
Biological Chemistry, 2004 AbstractThe zinc finger transcription factor MTF-1 (metalresponsive transcription factor-1) is conserved from insects to vertebrates. Its major role in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu[2+], Zn[2+] and Cd [2+].
Kuppusamy Balamurugan +5 more
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Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration [PDF]
Biological Chemistry, 2004 AbstractMetalresponsive transcription factor-1 (MTF-1) is a zinc finger protein with a central role in heavy metal homeostasis/ detoxification. MTF-1 binds to DNA sequence motifs known as metal response elements (MREs) with a core consensus TGCRCNC.
Y. Wang +3 more
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Cadmium‐induced gene expression is regulated by MTF‐1, a key metal‐responsive transcription factor [PDF]
Korean Journal of Biological Sciences, 2003 The transition metal cadmium is a serious occupational and environmental toxin. To inhibit cadmium‐induced damage, cells respond by increasing the expression of genes that encode stress‐responsive proteins. The metal‐regulatory transcription factor 1 (MTF‐1) is a key regulator of heavy‐metal induced transcription of metallothionein‐I and II and other ...
Ronojoy Sen Gupta, Joohong Ahnn
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