Macrophage metallothioneins participate in the antileishmanial activity of antimonials
Frontiers in Parasitology, 2023 Host cell functions that participate in the pharmacokinetics and pharmacodynamics (PK/PD) of drugs against intracellular pathogen infections are critical for drug efficacy.
Deninson Alejandro Vargas +10 more
doaj +1 more source
Human cells experience a Zn2+ pulse in early G1
Cell Reports, 2023 Summary: Zinc is an essential micronutrient required for all domains of life. Cells maintain zinc homeostasis using a network of transporters, buffers, and transcription factors.
Ananya Rakshit +4 more
doaj +1 more source
NNMT Orchestrates Metabolic-Epigenetic Reprogramming to Drive Macrophage-Myofibroblast Transition in Hypertrophic Scarring. [PDF]
Adv Sci (Weinh)In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Dong X +11 more
europepmc +2 more sources
Frontiers in Molecular Neuroscience, 2020 Parkinson’s disease (PD) is a neurodegenerative disease that affects substantia nigra dopamine neurons. Many studies have documented the role of oxidative stress and angiogenesis in the pathogenesis of PD.
Sabah H. El-Ghaiesh +9 more
doaj +1 more source
Interactions of zinc- and redox-signaling pathways
Redox Biology, 2021 Zinc and cellular oxidants such as reactive oxygen species (ROS) each participate in a multitude of physiological functions. There is considerable overlap between the affected events, including signal transduction.
Christopher Hübner, Hajo Haase
doaj +1 more source
Regulatory circuit of human microRNA biogenesis. [PDF]
PLoS Computational Biology, 2007 miRNAs (microRNAs) are a class of endogenous small RNAs that are thought to negatively regulate protein production. Aberrant expression of many miRNAs is linked to cancer and other diseases.
Ji Lee +3 more
doaj +1 more source
A combination of transcriptional and microRNA regulation improves the stability of the relative concentrations of target genes [PDF]
, 2013 It is well known that, under suitable conditions, microRNAs are able to fine tune the relative concentration of their targets to any desired value. We show that this function is particularly effective when one of the targets is a Transcription Factor (TF)
Baroudi, Mariama El +4 more
core +6 more sources
Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster [PDF]
, 2017 Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to heavy metals is mediated by the metal-responsive transcription factor 1 (MTF-1), which is conserved from Drosophila to humans. MTF-1
Barrón, Maite G. +5 more
core +1 more source
Analysis of Four Polymorphisms Located at the Promoter of the Estrogen Receptor Alpha ESR1 Gene in a Population With Gender Incongruence [PDF]
, 2020 [Abstract] Introduction: Gender incongruence defines a state in which individuals feel discrepancy between the sex assigned at birth and their gender. Some of these people make a social transition from male to female (transwomen) or from female to male ...
Almaraz, Mari Cruz +8 more
core +1 more source
Noise processing by microRNA-mediated circuits: The Incoherent Feed-Forward Loop, revisited [PDF]
, 2016 The intrinsic stochasticity of gene expression is usually mitigated in higher eukaryotes by post-transcriptional regulation channels that stabilise the output layer, most notably protein levels. The discovery of small non-coding RNAs (miRNAs) in specific
De Martino, Andrea +3 more
core +2 more sources