Results 51 to 60 of about 5,388 (199)
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyVeronika Pedrini‐Martha +4 more
openalex +2 more sources
A survey of well conserved families of C2H2 zinc-finger genes in Daphnia [PDF]
, 2010 Background A recent comparative genomic analysis tentatively identified roughly 40 orthologous groups of C2H2 Zinc-finger proteins that are well conserved in "bilaterians" (i.e. worms, flies, and humans).
Arun Seetharam, Yang Bai, Gary W Stuart
core +2 more sources
Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. [PDF]
, 2018 Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In conjunction with DNA transposition, the levels of multiple cell surface or intracellular
Chang, Howard Y +8 more
core +2 more sources
The functions of metamorphic metallothioneins in zinc and copper metabolism [PDF]
, 2017 Recent discoveries in zinc biology provide a new platform for discussing the primary physiological functions of mammalian metallothioneins (MTs) and their exquisite zinc-dependent regulation.
Krężel, Artur, Maret, Wolfgang
core +2 more sources
PLoS ONE, 2011 The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh +2 more
doaj +1 more source
The emerging role of zinc transporters in cellular homeostasis and cancer [PDF]
, 2017 Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of many cellular proteins. Cellular zinc homeostasis involves the opposing action of two families of metal transporters: the ZnT (SLC30) family that functions ...
Bafaro, Elizabeth +3 more
core +1 more source
Redox Biology, 2014 The effectiveness of current treatment for age related macular degeneration (AMD) by targeting one molecule is limited due to its multifactorial nature and heterogeneous pathologies.
Y. Li +6 more
doaj +1 more source
A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans [PDF]
, 2014 Zinc is essential for biological systems, and aberrant zinc metabolism is implicated in a broad range of human diseases. To maintain homeostasis in response to fluctuating levels of dietary zinc, animals regulate gene expression; however, mechanisms that
Cabrera, Daniel +7 more
core +2 more sources
Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter [PDF]
Biochemical Journal, 2013 Zinc is critical for a multitude of cellular processes, including gene expression, secretion and enzymatic activities. Cellular zinc is controlled by zinc-chelating proteins and by zinc transporters. The recent identification of zinc permeability of the lysosomal ion channel TRPML1 (transient receptor potential mucolipin 1), and the evidence of ...
Ira, Kukic +4 more
openaire +2 more sources
PLoS ONE, 2014 Zinc plays a critical role in many biological processes. However, it is toxic at high concentrations and its homeostasis is strictly regulated by metal-responsive transcription factor 1 (MTF-1) together with many other proteins to protect cells against ...
Wen-jie Zhao +8 more
doaj +1 more source