Results 21 to 30 of about 71,371 (293)
Bioresources and Bioprocessing, 2022 Terminators serve as the regulatory role in gene transcription termination; however, few researches about terminator optimization have been conducted, which leads to the lack of available and universal terminator for gene expression regulation in ...
Yi Rao +9 more
doaj +1 more source
Balanced branching in transcription termination [PDF]
Proceedings of the National Academy of Sciences, 2001 The theory of stochastic transcription termination based on free-energy competition [von Hippel, P. H. & Yager, T. D. (1992) Science 255, 809–812 and von Hippel, P. H. & Yager, T. D. (1991) Proc. Natl. Acad. Sci.
Harrington, K. J. +2 more
openaire +3 more sources
In-depth transcriptome analysis reveals novel TARs and prevalent antisense transcription in human cell lines. [PDF]
PLoS ONE, 2010 Several recent studies have indicated that transcription is pervasive in regions outside of protein coding genes and that short antisense transcripts can originate from the promoter and terminator regions of genes.
Daniel Klevebring +3 more
doaj +1 more source
The Bacillus subtilis TRAP protein can induce transcription termination in the leader region of the tryptophan biosynthetic (trp) operon independent of the trp attenuator RNA. [PDF]
PLoS ONE, 2014 In Bacillus subtilis, transcription of the tryptophan biosynthetic operon is regulated by an attenuation mechanism. When intracellular tryptophan levels are high, the TRAP protein binds to the 5' leader region of the nascent trp mRNA and induces ...
Natalie M McAdams, Paul Gollnick
doaj +1 more source
Tail Wags Dog’s SINE: Retropositional Mechanisms of Can SINE Depend on Its A-Tail Structure
Biology, 2022 SINEs, non-autonomous short retrotransposons, are widespread in mammalian genomes. Their transcripts are generated by RNA polymerase III (pol III). Transcripts of certain SINEs can be polyadenylated, which requires polyadenylation and pol III termination
Sergei A. Kosushkin +4 more
doaj +1 more source
Gene Architecture Facilitates Intron-Mediated Enhancement of Transcription
Frontiers in Molecular Biosciences, 2021 Introns impact several vital aspects of eukaryotic organisms like proteomic plasticity, genomic stability, stress response and gene expression. A role for introns in the regulation of gene expression at the level of transcription has been known for more ...
Katherine Dwyer +3 more
doaj +1 more source
An Allosteric Path to Transcription Termination [PDF]
Molecular Cell, 2007 Transcription termination signals in bacteria occur in RNA as a strong hairpin followed by a stretch of U residues at the 3' terminus. To release the transcript, RNA polymerase (RNAP) is thought to translocate forward without RNA synthesis.
Epshtein, Vitaly +4 more
openaire +2 more sources
Frontiers in Plant Science, 2023 Plants have recently received much attention as a means of producing recombinant proteins because they are easy to grow at a low cost and at a large scale.
Areum Yun +4 more
doaj +1 more source
Derailing the Locomotive: Transcription Termination [PDF]
Journal of Biological Chemistry, 2008 Transcription can be divided into three stages: initiation, elongation, and termination. Initiation involves the binding of RNA polymerase (RNAP)2 to a gene’s promoter and the beginning of RNA synthesis. Elongation involves lengthening the nascent transcript by the addition of nucleotides to the 3 -end of the RNA located in the active site of RNAP. The
David S, Gilmour, Ruopeng, Fan
openaire +2 more sources
Definition of RNA Polymerase II CoTC Terminator Elements in the Human Genome
Cell Reports, 2013 Mammalian RNA polymerase II (Pol II) transcription termination is an essential step in protein-coding gene expression that is mediated by pre-mRNA processing activities and DNA-encoded terminator elements.
Takayuki Nojima +4 more
doaj +1 more source