Results 41 to 50 of about 736,695 (298)
An Allosteric Path to Transcription Termination [PDF]
Molecular Cell, 2007 Transcription termination signals in bacteria occur in RNA as a strong hairpin followed by a stretch of U residues at the 3' terminus. To release the transcript, RNA polymerase (RNAP) is thought to translocate forward without RNA synthesis.
Epshtein, Vitaly +4 more
openaire +2 more sources
Cells, 2023 Therapy via the gene addition of the anti-sickling βAS3-globin transgene is potentially curative for all β-hemoglobinopathies and therefore of particular clinical and commercial interest.
Lola Koniali +13 more
doaj +1 more source
Structural basis for transcription antitermination at bacterial intrinsic terminator
Nature Communications, 2019 Bacteriophages reprogram the host transcriptional machinery. Here the authors provide insights into the mechanism of how bacteriophages regulate host transcription by determining the cryo-EM structures of two bacterial transcription elongation complexes ...
Linlin You +8 more
doaj +1 more source
The transcription and export complex THO/TREX contributes to transcription termination in plants.
PLoS Genetics, 2020 Transcription termination has important regulatory functions, impacting mRNA stability, localization and translation potential. Failure to appropriately terminate transcription can also lead to read-through transcription and the synthesis of antisense ...
Ghazanfar Abbas Khan +9 more
doaj +1 more source
Applied Sciences, 2021 Nucleic acid-based regulatory components provide a promising toolbox for constructing synthetic biological circuits due to their design flexibility and seamless integration towards complex systems.
Seongho Hong, Jeongwon Kim, Jongmin Kim
doaj +1 more source
P&TIT: A computer tool for predicting prototypical transcription promoter and terminator elements by conserved motifs [PDF]
, 2017 Over the last few decades, computational genomics has tremendously contributed to decipher biology from genome sequences and related data. Considerable effort has been devoted to prediction of transcription promoter and terminator sites that represent ...
Peano, Clelia +5 more
core +1 more source
Transcription termination and anti‐termination in E. coli [PDF]
Genes to Cells, 2002 Transcription termination in Escherichia coli is controlled by many factors. The sequence of the DNA template, the structure of the transcript, and the actions of auxiliary proteins all play a role in determining the efficiency of the process. Termination is regulated and can be enhanced or suppressed by host and phage proteins.
Evgeny, Nudler, Max E, Gottesman
openaire +2 more sources
Falling for the dark side of transcription: Nab2 fosters RNA polymerase III transcription. [PDF]
, 2016 RNA polymerase III (RNAPIII) synthesizes diverse, small, non-coding RNAs with many important roles in the cellular metabolism. One of the open questions of RNAPIII transcription is whether and how additional factors are involved.
Reuter, LM, Sträßer, K
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source