Results 31 to 40 of about 736,695 (298)
Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation [PDF]
, 2013 Type II DNA topoisomerases catalyse DNA double-strand cleavage, passage and re-ligation to effect topological changes. There is considerable interest in elucidating topoisomerase II roles, particularly as these proteins are targets for anti-cancer drugs.
Porter, Andrew C. G. +22 more
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Derailing the Locomotive: Transcription Termination [PDF]
Journal of Biological Chemistry, 2008 Transcription can be divided into three stages: initiation, elongation, and termination. Initiation involves the binding of RNA polymerase (RNAP)2 to a gene’s promoter and the beginning of RNA synthesis. Elongation involves lengthening the nascent transcript by the addition of nucleotides to the 3 -end of the RNA located in the active site of RNAP. The
David S, Gilmour, Ruopeng, Fan
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Frontiers in Plant Science, 2023 Plants have recently received much attention as a means of producing recombinant proteins because they are easy to grow at a low cost and at a large scale.
Areum Yun +4 more
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Rho-dependent terminators and transcription termination [PDF]
Microbiology, 2006 Rho-dependent transcription terminators participate in sophisticated genetic regulatory mechanisms, in both bacteria and phages; they occur in regulatory regions preceding the coding sequences of genes and within coding sequences, as well as at the end of transcriptional units, to prevent readthrough transcription.
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Regulation of Transcription Elongation and Termination [PDF]
Biomolecules, 2015 This article will review our current understanding of transcription elongation and termination in E. coli. We discuss why transcription elongation complexes pause at certain template sites and how auxiliary host and phage transcription factors affect elongation and termination.
Washburn, Robert, Gottesman, Max E.
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The Mechanism of Intrinsic Transcription Termination [PDF]
Molecular Cell, 1999 In bacteria, an intrinsic transcription termination signal appears in RNA as a hairpin followed by approximately eight uridines (U stretch) at the 3' terminus. This signal leads to rapid dissociation of the ternary elongation complex (TEC) into RNA, DNA, and an RNA polymerase.
Gusarov, Ivan, Nudler, Evgeny
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Topoisomerases, chromatin and transcription termination [PDF]
Transcription, 2011 In eukaryotes transcription is complicated by the DNA being packed in nucleosomes and by supercoils induced by opening of the DNA double helix during elongation. Here we discuss our recent genome-wide work regarding topoisomerases and their role in chromatin remodeling during the transcription cycle and we report a novel function for topoisomerases in ...
Mickaël, Durand-Dubief +3 more
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What Is in a Cat Scratch? Growth of Bartonella henselae in a Biofilm
Microorganisms, 2021 Bartonella henselae (B. henselae) is a gram-negative bacterium that causes cat scratch disease, bacteremia, and endocarditis, as well as other clinical presentations. B.
Udoka Okaro +2 more
doaj +1 more source
Nature Communications, 2020 Bacterial transcription is terminated when RNA polymerases encounter terminator sequences. Using a single-molecule fluorescence assay, here the authors show that the release of transcript RNA precedes RNA polymerase dissociation and that the remaining ...
Wooyoung Kang +6 more
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Plant Promoters and Terminators for High-Precision Bioengineering
BioDesign Research, 2023 High-precision bioengineering and synthetic biology require fine-tuning gene expression at both transcriptional and posttranscriptional levels. Gene transcription is tightly regulated by promoters and terminators.
Emily G. Brooks +9 more
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