Synthetic and Systems BiotechnologyThe primary function of terminators is to terminate transcription in gene expression. Although some studies have suggested that terminators also contribute positively to upstream gene expression, the extent and underlying mechanism of this effect remain ...
Jia-Wei Ren +10 more
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Mycobacterium tuberculosis PknK Substrate Profiling Reveals Essential Transcription Terminator Protein Rho and Two-Component Response Regulators PrrA and MtrA as Novel Targets for Phosphorylation [PDF]
Microbiology Spectrum, 2022 The Mycobacterium tuberculosis protein kinase K regulates growth adaptation by facilitating mycobacterial survival in response to a variety of in vitro and in vivo stress conditions.
Vandana Malhotra +7 more
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Transcription Terminator-Mediated Enhancement in Transgene Expression in Maize: Preponderance of the AUGAAU Motif Overlapping With Poly(A) Signals [PDF]
Frontiers in Plant Science, 2020 The selection of transcription terminators (TTs) for pairing with high expressing constitutive promoters in chimeric constructs is crucial to deliver optimal transgene expression in plants.
Po-Hao Wang +5 more
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Conserved 3′ stem-loop structures enable comprehensive analysis of bacterial transcription termination in metagenomes [PDF]
MicrobiomeBackground Bacterial transcription termination is a critical yet underexplored layer of gene regulation in microbial ecosystems. Existing computational tools, however, primarily focus on predicting transcript 3′ ends generated by Rho-independent ...
Yunfan Jin +8 more
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Effect of transcription terminator usage on the establishment of transgene transcriptional gene silencing [PDF]
BMC Research Notes, 2018 Objective Obtaining high and stable transgene expression is of vital importance for plant genetic engineering. A lot is known about the relationship between terminator efficiency and gene expression, but no studies have addressed the relationship between
Ana Pérez-González, Elena Caro
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Definition of RNA Polymerase II CoTC Terminator Elements in the Human Genome [PDF]
Cell Reports, 2013 Mammalian RNA polymerase II (Pol II) transcription termination is an essential step in protein-coding gene expression that is mediated by pre-mRNA processing activities and DNA-encoded terminator elements.
Takayuki Nojima +4 more
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WebGeSTer DB--a transcription terminator database. [PDF]
Nucleic Acids Res, 2011 We present WebGeSTer DB, the largest database of intrinsic transcription terminators (http://pallab.serc.iisc.ernet.in/gester). The database comprises of a million terminators identified in 1060 bacterial genome sequences and 798 plasmids. Users can obtain both graphic and tabular results on putative terminators based on default or user-defined ...
Mitra A +3 more
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Frontiers in Molecular Biosciences, 2021 An evolutionarily conserved feature of introns is their ability to enhance expression of genes that harbor them. Introns have been shown to regulate gene expression at the transcription and post-transcription level.
Katherine Dwyer +3 more
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Synthetic and Systems Biotechnology, 2022 The intrinsic terminator in prokaryotic forms secondary RNA structure and terminates the transcription. However, leaking transcription is common due to varied terminator strength.
Weiji Zhai +7 more
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Redundancy of primary RNA-binding functions of the bacterial transcription terminator Rho. [PDF]
Nucleic Acids Res, 2014 The bacterial transcription terminator, Rho, termi-nates transcription at half of the operons. According to the classical model derived from in vitro assays on a few terminators, Rho is recruited to the transcrip-tion elongation complex (EC) by ...
Shashni R +4 more
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