A Novel Mechanism for Transcription Termination in the mod(mdg4) Locus of Drosophila melanogaster
BiologyThis study investigated an alternative mechanism of transcription termination that occurs independently of polyadenylation. We focused on a non-canonical transcription terminator (NTT) identified in the mod(mdg4) gene of Drosophila melanogaster.
Iuliia V. Soldatova +3 more
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Design of novel peptide inhibitors against the conserved bacterial transcription terminator, Rho. [PDF]
J Biol Chem, 2021 The transcription terminator Rho regulates many physiological processes in bacteria, such as antibiotic sensitivity, DNA repair, RNA remodeling, and so forth, and hence, is a potential antimicrobial target, which is unexplored.
Ghosh G +5 more
europepmc +2 more sources
MicroorganismsThe ilvBNC operon in Corynebacterium glutamicum encodes key enzymes for the biosynthesis of branched-chain amino acids (L-isoleucine, L-leucine, and L-valine).
Ludmila E. Ryabchenko +8 more
doaj +2 more sources
The functional anatomy of an intrinsic transcription terminator [PDF]
The EMBO Journal, 2003 To induce dissociation of the transcription elongation complex, a typical intrinsic terminator forms a G.C-rich hairpin structure upstream from a U-rich run of approximately eight nucleotides that define the transcript 3' end. Here, we have adapted the nucleotide analog interference mapping (NAIM) approach to identify the critical RNA atoms and ...
Schwartz, A. +2 more
openaire +3 more sources
Redundancy of primary RNA-binding functions of the bacterial transcription terminator Rho. [PDF]
Nucleic Acids Res, 2014 The bacterial transcription terminator, Rho, termi-nates transcription at half of the operons. According to the classical model derived from in vitro assays on a few terminators, Rho is recruited to the transcrip-tion elongation complex (EC) by ...
Shashni R +4 more
europepmc +3 more sources
Analysis of the Genetic Determinants of Yersiniachelin Siderophore of Yersinia
Проблемы особо опасных инфекцийThe study is focused on the genetic determinants of the yersiniachelin (Ych) siderophore encoded by the ysu gene cluster and found only in Yersinia pestis and Yersinia pseudotuberculosis. The aim of the investigation was to analyze the genes encoding the
D. A. Kuznetsova +4 more
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A Bacteriophage Capsid Protein Is an Inhibitor of a Conserved Transcription Terminator of Various Bacterial Pathogens. [PDF]
J Bacteriol, 2018 Rho is a hexameric molecular motor that functions as a conserved transcription terminator in majority of the bacterial species, which is a potential drug target.
Ghosh G, Reddy J, Sambhare S, Sen R.
europepmc +3 more sources
Ere, a Family of Short Interspersed Elements in the Genomes of Odd-Toed Ungulates (Perissodactyla)
AnimalsShort Interspersed Elements (SINEs) are eukaryotic retrotransposons transcribed by RNA polymerase III (pol III). Many mammalian SINEs (T+ SINEs) contain a polyadenylation signal (AATAAA), a pol III transcription terminator, and an A-rich tail in their 3′-
Ilia G. Ustyantsev +4 more
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aCPSF1 cooperates with terminator U-tract to dictate archaeal transcription termination efficacy
eLife, 2021 Recently, aCPSF1 was reported to function as the long-sought global transcription termination factor of archaea; however, the working mechanism remains elusive.
Jie Li +6 more
doaj +1 more source
Frontiers in Plant Science, 2022 The role of terminators is more commonly associated with the polyadenylation and 3′ end formation of new transcripts. Recent evidence, however, suggests that this regulatory region can have a dramatic impact on gene expression.
Felipe Fenselau de Felippes +4 more
doaj +1 more source