Beet Curly Top Iran Virus Rep and V2 Suppress Post-Transcriptional Gene Silencing via Distinct Modes of Action [PDF]
Viruses, 2023 Beet curly top Iran virus (BCTIV) is a yield-limiting geminivirus belonging to the becurtovirus genus. The genome organization of BCTIV is unique such that the complementary strand of BCTIV resembles Mastrevirus, whereas the virion strand organization is
Saeideh Ebrahimi +7 more
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Aptamer-mediated transcriptional gene silencing of Foxp3 inhibits regulatory T cells and potentiates antitumor response [PDF]
Molecular Therapy: Nucleic Acids, 2021 The inhibition of immunosuppressive mechanisms may switch the balance between tolerance and surveillance, leading to an increase in antitumor activity. Regulatory T cells play an important role in the control of immunosuppression, exhibiting the unique ...
Andrea J. Manrique-Rincón +8 more
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Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus. [PDF]
World J Virol, 2015 While human immunodeficiency virus 1 (HIV-1) infection is controlled through continuous, life-long use of a combination of drugs targeting different steps of the virus cycle, HIV-1 is never completely eradicated from the body. Despite decades of research there is still no effective vaccine to prevent HIV-1 infection.
Méndez C, Ahlenstiel CL, Kelleher AD.
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Transcriptional gene silencing in humans. [PDF]
Nucleic Acids Res, 2016 It has been over a decade since the first observation that small non-coding RNAs can functionally modulate epigenetic states in human cells to achieve functional transcriptional gene silencing (TGS). TGS is mechanistically distinct from the RNA interference (RNAi) gene-silencing pathway.
Weinberg MS, Morris KV.
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Antisense transcription licenses nascent transcripts to mediate transcriptional gene silencing. [PDF]
Genes Dev, 2016 In eukaryotes, antisense transcription can regulate sense transcription by induction of epigenetic modifications. We showed previously that antisense transcription triggers Dicer-independent siRNA (disiRNA) production and disiRNA locus DNA methylation (DLDM) in Neurospora crassa.
Dang Y, Cheng J, Sun X, Zhou Z, Liu Y.
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Therapeutic potential of siRNA-mediated transcriptional gene silencing
BioTechniques, 2006 RNA interference (RNAi) and specifically the use of small interfering RNAs (siRNAs) represents a potentially new paradigm in gene knockout technology. Clearly siRNAs can be used to knockdown the expression of a targeted transcript in what has been termed
Kevin V. Morris
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C4, the Pathogenic Determinant of Tomato Leaf Curl Guangdong Virus, May Suppress Post-transcriptional Gene Silencing by Interacting With BAM1 Protein [PDF]
Frontiers in Microbiology, 2020 Tomato leaf curl Guangdong virus (ToLCGdV) is a begomovirus associated with a Tomato yellow leaf curl disease (TYLCD) epidemic in Guangdong province, China.
Zhenggang Li +10 more
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Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. [PDF]
PLoS Pathogens, 2018 Gene silencing is a natural antiviral defense mechanism in plants. For effective infection, plant viruses encode viral silencing suppressors to counter this plant antiviral response.
Asigul Ismayil +14 more
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Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development
Frontiers in Plant Science, 2021 Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism.
Ahmed H. El-Sappah +22 more
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Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. [PDF]
PLoS Genetics, 2008 Small RNAs targeted to gene promoters in human cells have been shown to modulate both transcriptional gene suppression and activation. However, the mechanism involved in transcriptional activation has remained poorly defined, and an endogenous RNA ...
Kevin V Morris +4 more
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