Results 21 to 30 of about 234,470 (259)

Endogenous Targets of Transcriptional Gene Silencing in Arabidopsis [PDF]

The Plant Cell, 2000
Transcriptional gene silencing (TGS) frequently inactivates foreign genes integrated into plant genomes but very likely also suppresses an unknown subset of chromosomal information. Accordingly, RNA analysis of mutants impaired in silencing should uncover endogenous targets of this epigenetic regulation.
Steimer, A., Amadeo, P., Afsar, K., Fransz, P.F., Mittelsten Scheid, O., Paszkowski, J.   +5 more
openaire   +4 more sources

RNA-interference components are dispensable for transcriptional silencing of the drosophila bithorax-complex.

PLoS ONE, 2013
BackgroundBeyond their role in post-transcriptional gene silencing, Dicer and Argonaute, two components of the RNA interference (RNAi) machinery, were shown to be involved in epigenetic regulation of centromeric heterochromatin and transcriptional gene ...
Filippo M Cernilogar, A Maxwell Burroughs, Chiara Lanzuolo, Achim Breiling, Axel Imhof, Valerio Orlando   +5 more
doaj   +1 more source

eIF4GI facilitates the MicroRNA-mediated gene silencing. [PDF]

PLoS ONE, 2013
MicroRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional gene silencing by binding to complementary target mRNAs and recruiting the miRNA-containing ribonucleoprotein complexes to the mRNAs.
Incheol Ryu, Ji Hoon Park, Sihyeon An, Oh Sung Kwon, Sung Key Jang   +4 more
doaj   +1 more source

RNA duplexes in transcriptional regulation

Biomolecular Concepts, 2010
Transcriptional regulation by small RNA molecules, including small interfering RNA and microRNA, has emerged as an important gene expression modulator.
Swaminathan Sanjay, Hood Chantelle L., Suzuki Kazuo, Kelleher Anthony D.   +3 more
doaj   +1 more source

In vivo expression of MHC class I genes depends on the presence of a downstream barrier element. [PDF]

PLoS ONE, 2009
Regulation of MHC class I gene expression is critical to achieve proper immune surveillance. In this work, we identify elements downstream of the MHC class I promoter that are necessary for appropriate in vivo regulation: a novel barrier element that ...
Helit Cohen, Palak Parekh, Zeynep Sercan, Aparna Kotekar, Jocelyn D Weissman, Dinah S Singer   +5 more
doaj   +1 more source

RNA Silencing against Geminivirus: Complementary Action of Posttranscriptional Gene Silencing and Transcriptional Gene Silencing in Host Recovery [PDF]

Journal of Virology, 2009
ABSTRACT RNA silencing in plants is a natural defense system mechanism against invading nucleic acids such as viruses. Geminiviruses, a family of plant viruses characterized by a circular, single-stranded DNA genome, are thought to be both inducers and targets of RNA silencing.
Edgar A, Rodríguez-Negrete, Jimena, Carrillo-Tripp, Rafael F, Rivera-Bustamante   +2 more
openaire   +2 more sources

Transcriptional Gene Silencing (TGS) via the RNAi Machinery in HIV-1 Infections

Biology, 2012
Gene silencing via non-coding RNA, such as siRNA and miRNA, can occur at the transcriptional, post-transcriptional, and translational stages of expression.
Fatah Kashanchi, Kylene Kehn-Hall, Aarthi Narayanan, Zachary Klase, Elizabeth Jaworski, Ravi Das, Irene Guendel, Gavin C. Sampey   +7 more
doaj   +1 more source

The convergence of autophagy, small RNA and the stress response – implications for transgenerational epigenetic inheritance in plants

Biomolecular Concepts, 2014
Recent discoveries in eukaryotes have shown that autophagy-mediated degradation of DICER and ARGONAUTE (AGO), the proteins involved in post-transcriptional gene silencing (PTGS), can occur in response to viral infection and starvation.
Youngson Neil A., Lin Pin-Chun, Lin Shih-Shun   +2 more
doaj   +1 more source

Enhancement of post-transcriptional gene silencing by grafting [PDF]

Plant Signaling & Behavior, 2008
We showed previously that grafting transmitted silencing occurred when transgenic ACC oxidase 1 (ACO1) overexpressing tomato plants that also produced siRNAs were grafted onto transgenic stocks that already showed strong silencing. The presence of siRNAs in these overexpressing scions may indicate that silencing, though inefficient, may already occur ...
Yuanhuai, Han, Donald, Grierson
openaire   +2 more sources

A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus

Molecular Therapy: Nucleic Acids, 2014
This review discusses recent developments in the use of non-coding RNAs (ncRNAs) for the regulation of therapeutically relevant genes, with special focus on applications for the treatment of cardiovascular diseases.
Tiia Husso, Seppo Ylä-Herttuala, Mikko P Turunen   +2 more
doaj   +1 more source