Results 31 to 40 of about 234,470 (259)

Preventing transcriptional gene silencing by active DNA demethylation [PDF]

FEBS Letters, 2005
DNA methylation is important for stable transcriptional gene silencing. DNA methyltransferases for de novo as well as maintenance methylation have been well characterized. However, enzymes responsible for active DNA demethylation have been elusive and several reported mechanisms of active demethylation have been controversial. There has been a critical
Kapoor, Avnish, Agius, Fernanda, Zhu, Jian-Kang   +2 more
openaire   +2 more sources

A high-resolution map of transcriptional repression

eLife, 2017
Turning genes on and off is essential for development and homeostasis, yet little is known about the sequence and causal role of chromatin state changes during the repression of active genes.
Ziwei Liang, Karen E Brown, Thomas Carroll, Benjamin Taylor, Isabel Ferreirós Vidal, Brian Hendrich, David Rueda, Amanda G Fisher, Matthias Merkenschlager   +8 more
doaj   +1 more source

AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana. [PDF]

PLoS ONE, 2011
RNA-directed DNA methylation (RdDM) is a small interfering RNA (siRNA)-mediated epigenetic modification that contributes to transposon silencing in plants. RdDM requires a complex transcriptional machinery that includes specialized RNA polymerases, named
Changho Eun, Zdravko J Lorkovic, Ulf Naumann, Quan Long, Ericka R Havecker, Stacey A Simon, Blake C Meyers, Antonius J M Matzke, Marjori Matzke   +8 more
doaj   +1 more source

Overexpression of Arabidopsis thaliana ERI, the homolog of C. elegans Enhancer of RNAinterference, leads to enhanced growth

Frontiers in Plant Science, 2015
Organisms adopt a wide range of strategies to adapt to change. Gene silencing describes the ability of organisms to modulate the expression of susceptible genes at certain times at the transcriptional or the translational level.
Rhonda C Meyer, Gunnar eHönig, Ronny eBrandt, Fernando eArana-Ceballos, Cathleen eNeitsch, Gunter eReuter, Thomas eAltmann, Markus eKuhlmann   +7 more
doaj   +1 more source

Epigenetic transcriptional gene silencing in Entamoeba histolytica [PDF]

IUBMB Life, 2008
AbstractThe human intestinal pathogen Entamoeba histolytica has a number of virulence factors which can cause damage to the host. Transcriptional silencing of the gene coding for one of its major toxic molecules, the amoebapore (Ehap‐a), occurred following the transfection of amoebic trophozoites with a plasmid containing the 5′ promoter region of Ehap‐
David, Mirelman, Michael, Anbar, Rivka, Bracha   +2 more
openaire   +2 more sources

Transcriptional silencing of multiple genes in trophozoites of Entamoeba histolytica. [PDF]

PLoS Pathogens, 2006
In a previous work we described the transcriptional silencing of the amoebapore A (AP-A) gene (Ehap-a) of Entamoeba histolytica strain HM-1:IMSS. The silencing occurred following transfection with a plasmid containing a 5' upstream region (473 bp) of ...
Rivka Bracha, Yael Nuchamowitz, Michael Anbar, David Mirelman   +3 more
doaj   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

Nature Communications, 2019
In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.
Antoine Campagne, Ming-Kang Lee, Dina Zielinski, Audrey Michaud, Stéphanie Le Corre, Florent Dingli, Hong Chen, Lara Z. Shahidian, Ivaylo Vassilev, Nicolas Servant, Damarys Loew, Eric Pasmant, Sophie Postel-Vinay, Michel Wassef, Raphaël Margueron   +14 more
doaj   +1 more source

The post-transcriptional gene silencing pathway in Eucalyptus

Genetics and Molecular Biology, 2005
Post-transcriptional gene silencing (PTGS) is a conserved surveillance mechanism that identifies and cleaves double-stranded RNA molecules and their cellular cognate transcripts.
Flávio Tetsuo Sassaki, Tiago Campos-Pereira, Ivan de Godoy Maia   +2 more
doaj   +1 more source

Post-transcriptional gene silencing: Basic concepts and applications

Journal of Biosciences, 2020
Post-transcriptional gene silencing (PTGS)-mediated gene silencing exploits the cellular mechanism wherein transcripts having sequence similarity to the double-stranded RNA (dsRNA) molecules present in the cell will be subjected to degradation. PTGS is closely related to natural processes such as RNA-mediated virus resistance and cross-protection in ...
Mohd Ashraf, Ashfaq, V Dinesh, Kumar, P Soma Sekhar, Reddy, C H Anil, Kumar, K Sai, Kumar, N Narasimha, Rao, M, Tarakeswari, M, Sujatha   +7 more
openaire   +2 more sources