Results 61 to 70 of about 345,542 (371)

A multi-tissue, splicing-based joint transcriptome-wide association study identifies susceptibility genes for breast cancer. [PDF]

Am J Hum Genet
Gao G, McClellan J, Barbeira AN, Fiorica PN, Li JL, Mu Z, Olopade OI, Huo D, Im HK.   +8 more
europepmc   +2 more sources

Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits. [PDF]

Am J Hum Genet
Wittich H, Ardlie K, Taylor KD, Durda P, Liu Y, Mikhaylova A, Gignoux CR, Cho MH, Rich SS, Rotter JI, NHLBI TOPMed Consortium, Manichaikul A, Im HK, Wheeler HE.   +13 more
europepmc   +2 more sources

Transcriptome-wide association studies: opportunities and challenges [PDF]

, 2017
Transcriptome-wide association studies (TWAS) integrate GWAS and gene expression datasets to find gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes, using simulations and case studies of literature-curated candidate causal genes for schizophrenia, LDL cholesterol and Crohn’s ...
Wainberg, Michael, Sinnott-Armstrong, Nasa, Mancuso, Nicholas, Barbeira, Alvaro N., Knowles, David A, Golan, David, Ermel, Raili, Ruusalepp, Arno, Quertermous, Thomas, Hao, Ke, Björkegren, Johan LM, Kyung Im, Hae, Pasaniuc, Bogdan, Rivas, Manuel A, Kundaje, Anshul   +14 more
openaire   +1 more source

Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia. [PDF]

, 2016
Autism (AUT), schizophrenia (SCZ) and bipolar disorder (BPD) are three highly heritable neuropsychiatric conditions. Clinical similarities and genetic overlap between the three disorders have been reported; however, the causes and the downstream effects ...
Arking, DE, Ellis, SE, Panitch, R, West, AB   +3 more
core   +1 more source

Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance

Molecular Psychiatry, 2022
Postpartum depression (PPD) affects 1 in 7 women and has negative mental health consequences for both mother and child. However, the precise biological mechanisms behind the disorder are unknown.
Jerry D Guintivano, K. Åberg, S. Clark, D. Rubinow, Patrick F. Sullivan, S. Meltzer-Brody, E. van den Oord   +6 more
semanticscholar   +1 more source

Transcriptome‐wide association study identifies multiple genes and pathways associated with pancreatic cancer

Cancer Medicine, 2018
Aim To identify novel candidate genes for pancreatic cancer. Methods We performed a transcriptome‐wide association study (TWAS) analysis of pancreatic cancer (PC).
Liuyun Gong, Dan Zhang, Yutiantian Lei, Yuanjie Qian, Xinyue Tan, Suxia Han   +5 more
doaj   +1 more source

Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]

, 2017
The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul, Gomez-Pinilla, Fernando, Meng, Qingying, Yang, Xia, Ying, Zhe, Zhuang, Yumei   +5 more
core   +2 more sources

Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposing

European Neuropsychopharmacology, 2021
Major depressive disorder (MDD) is the single largest contributor to global disability and up to 20–30% of patients do not respond to at least two antidepressants (treatment-resistant depression, TRD).
C. Fabbri, Oliver Pain, S. Hagenaars, C. Lewis, A. Serretti   +4 more
semanticscholar   +1 more source

A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk

Frontiers in Genetics, 2022
Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression. While eQTL studies of long RNAs has yielded many potential risk genes, the relationship between PrCa risk ...
Larson, Nicholas B., McDonnell, Shannon K., Fogarty, Zachary, Liu, Yuanhang, French, Amy J., Tillmans, Lori S., Cheville, John C., Wang, Liang, Schaid, Daniel J., Thibodeau, Stephen N.   +9 more
openaire   +3 more sources

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

Frontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng, Mengnan Lu, Lin Liu, Ke Xu, Peng Xu   +4 more
doaj   +1 more source