Results 71 to 80 of about 345,542 (371)

Transcriptome-wide association study of inflammatory biologic age

Aging, 2017
Chronic low grade inflammation is a fundamental mechanism of aging. We estimated biologic age using nine biomarkers from diverse inflammatory pathways and we hypothesized that genes associated with inflammatory biological age would provide insights into human aging. In Framingham Offspring Study participants at examination 8 (2005 to 2008), we used the
Lin, Honghuang, Lunetta, Kathryn L., Zhao, Qiang, Rong, Jian, Benjamin, Emelia J., Levy, Daniel, Larson, Martin G., Murabito, Joanne M., Mendelson, Michael, Joehanes, Roby   +9 more
openaire   +3 more sources

Integrative analysis of transcriptome-wide association study and gene expression profiling identifies candidate genes associated with stroke [PDF]

PeerJ, 2019
Background Stroke is a major public health burden worldwide. Although genetic variation is known to play a role in the pathogenesis of stroke, the specific pathogenic mechanisms are still unclear.
Jian Yang, Bin Yan, Yajuan Fan, Lihong Yang, Binbin Zhao, Xiaoyan He, Qingyan Ma, Wei Wang, Ling Bai, Feng Zhang, Xiancang Ma   +10 more
doaj   +2 more sources

Transcriptome-Wide Association Study Reveals Two Genes that Influence Mismatch Negativity [PDF]

SSRN Electronic Journal, 2020
Mismatch negativity (MMN) is a differential electrophysiological response measuring cortical adaptability to unpredictable stimuli. MMN is consistently attenuated in patients with psychosis. However, the genetics of MMN are uncharted, limiting the validation of MMN as a psychosis endophenotype. Here, we perform a transcriptome-wide association study of
Bhat, Anjali, Irizar, Haritz, Thygesen, Johan Hilge, Kuchenbaecker, Karoline, Pain, Oliver, Adams, Rick A., Zartaloudi, Eirini, Harju-seppänen, Jasmine, Austin-zimmerman, Isabelle, Wang, Baihan, Muir, Rebecca, Summerfelt, Ann, Du, Xiaoming Michael, Bruce, Heather, O’donnell, Patricio, Srivastava, Deepak P., Friston, Karl, Hong, L. Elliot, Hall, Mei-hua, Bramon, Elvira   +19 more
openaire   +5 more sources

Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs. [PDF]

, 2018
Approximately 1500 RNA-binding proteins (RBPs) profoundly impact mammalian cellular function by controlling distinct sets of transcripts, often using sequence-specific binding to 3' untranslated regions (UTRs) to regulate mRNA stability and translation ...
Estep, Jason A, Karginov, Fedor V, Li, Yahui, Nguyen, Daniel K, Sternburg, Erin L   +4 more
core   +3 more sources

UTMOST, a single and cross-tissue TWAS (Transcriptome Wide Association Study), reveals new ASD (Autism Spectrum Disorder) associated genes

Translational Psychiatry, 2021
Autism spectrum disorders (ASD) is a complex neurodevelopmental disorder that may significantly impact on the affected individual’s life. Common variation (SNPs) could explain about 50% of ASD heritability.
C. Rodriguez-Fontenla, Á. Carracedo
semanticscholar   +1 more source

TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies

Nucleic Acids Research, 2022
Abstract Transcriptome-wide association studies (TWASs), as a practical and prevalent approach for detecting the associations between genetically regulated genes and traits, are now leading to a better understanding of the complex mechanisms of genetic variants in regulating various diseases and traits.
Mingming Lu, Yadong Zhang, Fengchun Yang, Jialin Mai, Qianwen Gao, Xiaowei Xu, Hongyu Kang, Li Hou, Yunfei Shang, Qiheng Qain, Jie Liu, Meiye Jiang, Hao Zhang, Congfan Bu, Jinyue Wang, Zhewen Zhang, Zaichao Zhang, Jingyao Zeng, Jiao Li, Jingfa Xiao   +19 more
openaire   +2 more sources

Genetic regulation of mouse liver metabolite levels. [PDF]

, 2014
We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J, Che, Nam, Ghazalpour, Anatole, Hagopian, Raffi, He, Aiqing, Kayne, Paul, Kirchgessner, Todd, Lusis, Aldons J, Orozco, Luz, Pan, Calvin, Shih, Diana, Yang, Wen-pin   +11 more
core   +1 more source

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes

Basic Research in Cardiology, 2022
The majority of risk loci identified by genome-wide association studies (GWAS) are in non-coding regions, hampering their functional interpretation. Instead, transcriptome-wide association studies (TWAS) identify gene-trait associations, which can be ...
Ling Li, Zhifen Chen, M. von Scheidt, Shuangyue Li, Andrea Steiner, Ulrich Güldener, Simon Koplev, Angela Ma, Ke Hao, Calvin Pan, A. Lusis, S. Pang, T. Kessler, R. Ermel, Katyayani Sukhavasi, A. Ruusalepp, J. Gagneur, J. Erdmann, J. Kovacic, J. Björkegren, H. Schunkert   +20 more
semanticscholar   +1 more source

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]

, 2019
Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh, Chopra, Nipun, Edenberg, Howard J, Kelsoe, John, Lahiri, Debomoy K, Liu, Yunlong, Maloney, Bryan, Nurnberger, John I   +7 more
core   +3 more sources

Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes. [PDF]

J Transl Autoimmun
Psoriasis is a chronic, immune-mediated inflammatory skin disorder with a strong genetic component. Although numerous GWAS have identified risk loci, many associated variants lie in non-coding regions, complicating functional interpretation.This study aimed to identify novel psoriasis susceptibility genes by integrating large-scale GWAS and eQTL data ...
Yan F, Tao J, Liu J, Chen Y, Huang Z.
europepmc   +4 more sources