Results 131 to 140 of about 122,409 (259)

Thymocyte/Splenocyte-Derived CD4+CD25+Treg Stimulated by Anti-CD200R2 Derived Dendritic Cells Suppress Mixed Leukocyte Cultures and Skin Graft Rejection

, 2006
Reginald M. Gorczynski
openalex   +1 more source

The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates [PDF]

, 2007
Aftab A. Ansari, Lara Pereira, Ann E. Mayne, Nattawat Onlamoon, Kovit Pattanapanyasat, Kazuyasu Mori, François Villinger   +6 more
openalex   +1 more source

Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell‐Derived Exosomes for Suppressing Tumor Progression and Metastasis

Advanced Science, EarlyView.
The study develops engineered exosomes (EmDEX@GA) for locoregional immunomodulation of tumor‐draining lymph node (TDLN). EmDEX@GA can actively target to TDLN and remodel its immunosuppressive microenvironment through the synergistic effects of PD‐1/PD‐L1 blockade and STING pathway activation, subsequently enhance anti‐tumor immunity and suppress tumor ...
Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Yadong Liu, Moyang Chen, Guanghao Zhu, Xinqiu Song, Lili Cheng, Bo Liu, Jie Liu, Jie Ren   +12 more
wiley   +1 more source

Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen [PDF]

, 2007
Jin Zheng, M. Eric Kohler, Qingrong Chen, James J. Weber, Javed Khan, Bryon D. Johnson, Rimas J. Orentas   +6 more
openalex   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

A necroptosis‐related gene signature for predicting prognosis, immune landscape, and drug sensitivity in hepatocellular carcinoma

Cancer Medicine, Volume 11, Issue 24, Page 5079-5096, December 2022., 2022
Necroptosis is a newly discovered form of cell necrosis that plays a vital role in cancer development. We identified a necroptosis‐related gene signature based on the TCGA cohort, which was validated externally in the ICGC‐LIRI‐JP and GSE14520 cohorts.
Junliang Chen, Huaitao Wang, Lei Zhou, Zhihao Liu, Hui Chen, Xiaodong Tan   +5 more
wiley   +1 more source

A Copper‐Based Photothermal‐Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self‐Amplified Cuproptosis for Synergistic Cancer Therapy

Advanced Science, EarlyView.
This study introduces cuproptosis nanoplatform, a novel nanoplatform using Cu2−XS hollow nanospheres, elesclomol, and lauric acid (LA) for self‐amplified cuproptosis. NIR‐II laser activation melts LA, releasing copper ions and elesclomol to enhance copper delivery within tumor cells, reduce glutathione's inhibitory effect, and trigger immunogenic cell ...
Runzi Cheng, Zhenhao Li, Weican Luo, Hongwu Chen, Tingting Deng, Zhenqi Gong, Qing Zheng, Baizhi Li, Yongming Zeng, Huaiming Wang, Cong Huang   +10 more
wiley   +1 more source

A novel Pyroptosis‐related long non‐coding RNA signature for predicting the prognosis and immune landscape of head and neck squamous cell carcinoma

Cancer Medicine, Volume 11, Issue 24, Page 5097-5112, December 2022., 2022
our findings robustly demonstrate that our constructed prlncRNA signature could serve as an efficient indicator of prognosis, immunotherapy response, and chemosensitivity for HNSCC patients. Abstract Background Pyroptosis plays an essential function in carcinogenesis and the antitumor immune response.
Chongchang Zhou, Yiming Shen, Yangli Jin, Zhisen Shen, Dong Ye, Yi Shen, Hongxia Deng   +6 more
wiley   +1 more source

Deficient SOCS3 expression in CD4⁺CD25⁺FoxP3⁺ regulatory T cells and SOCS3‐mediated suppression of Treg function [PDF]

, 2007
Brendan B. L. Pillemer, Hui Xu, Timothy B. Oriss, Zengbiao Qi, Anuradha Ray   +4 more
openalex   +1 more source

Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway

Advanced Science, EarlyView.
The multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) significantly downregulated the JAK2‐STAT3 signaling pathway, which effectively inhibited the proliferation and growth of HCC with incomplete microwave ablation. Furthermore, the released bimetallic ions (Ca2⁺ and Zn2⁺) synergistically enhanced oxidative stress‐mediated cytotoxicity ...
Yuan Ling, Xiayi Liang, Kangning Yan, Guichun Zeng, Xiaoqi Zhu, Jinghang Jiang, Shaolong Lu, Xiaobo Wang, Yuying Zhou, Zhaoshen Li, Wei Mai, Duo Wang, Jie Chen   +12 more
wiley   +1 more source