Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody
OncoImmunology, 2019 Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao +13 more
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Frontiers in Immunology, 2022 BackgroundMesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have been increasingly proved as promising immunomodulators against some autoimmune disorders.
Na Li +6 more
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Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective [PDF]
, 2015 Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression.
Ono, M, Tanaka, RJ
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Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]
, 2020 Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis +15 more
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Expression of Helper and Regulatory T Cells in Atopic Dermatitis: A Meta-Analysis
Frontiers in Pediatrics, 2022 BackgroundAtopic dermatitis (AD) is a common inflammatory skin disease, with the incidence peaks in infancy. A meta-analysis was performed to assess the levels of T helper type 22 (Th22) cells, T helper type 17 (Th17) cells, interleukin (IL)-17, and ...
Dao-jun Zhang +3 more
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Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy [PDF]
, 2017 Regulatory T cells (Tregs) have been proposed to dampen functions of anti-neoplastic immune cells and thus promote cancer progression. In a phase IV trial (Re:Mission Trial, NCT01347996, http://www.clinicaltrials.gov ) 84 patients (age 18-79) with acute ...
Aurelius, Johan +13 more
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Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients [PDF]
, 2014 Objective: Regulatory T cells (Tregs) are known to infiltrate the tumour microenvironment of many cancers, including head and neck malignancies, and are thought to contribute to the host's impaired anti-tumour immune response.
Drennan, Samantha +3 more
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Journal of Asthma and Allergy, 2022 Hua Feng,1,2 Xiujuan Xiong,3 Zhuo Chen,1 Nan Luo,2 Yongning Wu1,4,5 1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330000, People’s Republic of China; 2School of Public Health, Nanchang University, Nanchang, 330006 ...
Feng H, Xiong X, Chen Z, Luo N, Wu Y
doaj
The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis
Virulence, 2020 Infection with intravascular platyhelminths of the genus Schistosoma can result in the debilitating disease schistosomiasis. Schistosomes (blood flukes) can survive in the host for many years.
Catherine S. Nation +2 more
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Target Transformed Regression for Accurate Tracking [PDF]
arXiv, 2021 Accurate tracking is still a challenging task due to appearance variations, pose and view changes, and geometric deformations of target in videos. Recent anchor-free trackers provide an efficient regression mechanism but fail to produce precise bounding box estimation. To address these issues, this paper repurposes a Transformer-alike regression branch,
arxiv