Results 21 to 30 of about 203,023 (389)
Nature Communications, 2022 Cell-based immunotherapies can provide safe and effective treatments for various disorders including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral infections.
K. Piekarska +15 more
semanticscholar +1 more source
Tissue-specific Tregs in cancer metastasis: opportunities for precision immunotherapy
Cellular & Molecular Immunology, 2021 Decades of advancements in immuno-oncology have enabled the development of current immunotherapies, which provide long-term treatment responses in certain metastatic cancer patients.
L. Huppert +6 more
semanticscholar +1 more source
Recruitment and Expansion of Tregs Cells in the Tumor Environment—How to Target Them?
Cancers, 2021 Simple Summary The immune response against cancer is generated by effector T cells, among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that mediate and support the immune response.
Justine Cinier +7 more
semanticscholar +1 more source
The dark side of Tregs during aging
Frontiers in Immunology, 2022 In the last century, we have seen a dramatic rise in the number of older persons globally, a trend known as the grey (or silver) tsunami. People live markedly longer than their predecessors worldwide, due to remarkable changes in their lifestyle and in ...
Martina Palatella +3 more
semanticscholar +1 more source
Science immunology, 2022 Regulatory T cells (Tregs) in nonlymphoid organs provide critical brakes on inflammation and regulate tissue homeostasis. Although so-called “tissue Tregs” are phenotypically and functionally diverse, serving to optimize their performance and survival ...
Tianli Xiao +6 more
semanticscholar +1 more source
CD8+ Tregs revisited: A heterogeneous population with different phenotypes and properties
European Journal of Immunology, 2021 Regulatory T cells (Tregs) play a key role in the peripheral self‐tolerance and preventing autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ counterparts are still controversial in many aspects including their phenotypic ...
V. Niederlova +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Although cancers arise from genetic mutations enabling cells to proliferate uncontrollably, they cannot thrive without failure of the anticancer immunity due in a large part to the tumor environment's influence on effector and regulatory T cells.
J. González-Navajas +6 more
semanticscholar +1 more source
Once a Treg, always a Treg? [PDF]
Immunological Reviews, 2014 SummaryRegulatory T cells (Tregs) prevail as a specialized cell lineage that has a central role in the dominant control of immunological tolerance and maintenance of immune homeostasis. Thymus‐derived Tregs (tTregs) and their peripherally induced counterparts (pTregs) are imprinted with unique Forkhead box protein 3 (Foxp3)‐dependent and independent ...
Deepali V, Sawant, Dario A A, Vignali
openaire +2 more sources
Toxins, 2020 Bee venom phospholipase A2 is a lipolytic enzyme in bee venom that catalyzes hydrolysis of the sn-2 ester bond of membrane phospholipids to produce free fatty acid and lysophospholipids.
Hyunjung Baek +6 more
doaj +1 more source
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
Nature Communications, 2021 The use of chimeric antigen receptor (CAR)-engineered regulatory T cells (Tregs) has emerged as a promising strategy to promote immune tolerance. However, in conventional T cells (Tconvs), CAR expression is often associated with tonic signaling, which ...
B. Lamarthée +22 more
semanticscholar +1 more source