Results 31 to 40 of about 93,800 (248)

L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma

Cancer Biology & Medicine, 2021
Objective: L1 cell adhesion molecule (L1CAM) exhibits oncogenic activity in tumors. However, the link between L1CAM and the tumor microenvironment remains poorly understood in patients with esophageal squamous cell carcinoma (ESCC).
Xuan Zhao, Shasha Liu, Xinfeng Chen, Jianyi Zhao, Feng Li, Qitai Zhao, Tan Xie, Lan Huang, Zhen Zhang, Yu Qi, Yang Yang, Song Zhao, Yi Zhang   +12 more
doaj   +1 more source

Tumor inflating lymphocytes. Purification, expanding and cytotoxicity analisys on primary tumor cultures [PDF]

Клиническая практика, 2020
Background. Tumor Infiltrating Lymphocytes (TILs) is one of the most promising sources of autologous cytotoxic T-cells for adoptive immunotherapy, which has already shown high efficiency in the treatment of metastatic melanoma.
G. M. Yusubalieva, S. V. Petrichuk, A. L. Krivoshapkin, A. G. Kedrova, Yu. V. Ivanov, A. G. Vinokurov, A. A. Kalinkin, A. E. Sandjarov, S. V. Kim, A. V. Ponomarev, D. G. Kuptsova, Roman Ischenko, Alexander Troitskiy, V. P. Baklaushev   +13 more
doaj   +1 more source

Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression

Epigenetics, 2018
IL2RA, a subunit of the high affinity receptor for interleukin-2 (IL2), plays a crucial role in immune homeostasis. Notably, IL2RA expression is induced in CD4+ T cells in response to various stimuli and is constitutive in regulatory T cells (Tregs).
Marie-Pierre Belot, Anne-Laure Castell, Sophie Le Fur, Pierre Bougnères   +3 more
doaj   +1 more source

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127pos Depletion, Treg Expansion, and Treg Cryopreservation

PLoS ONE, 2008
Treg based immunotherapy is of great interest to facilitate tolerance in autoimmunity and transplantation. For clinical trials, it is essential to have a clinical grade Treg isolation protocol in accordance with Good Manufacturing Practice (GMP) guidelines.
Peters, J.H., Preijers, F.W.M.B., Woestenenk, R.M., Hilbrands, L.B., Koenen, H.J.P.M., Joosten, I.   +5 more
openaire   +5 more sources

Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions [PDF]

Cellular & Molecular Immunology, 2020
The vast majority of Foxp3+ regulatory T cells (Tregs) are generated in the thymus, and several factors, such as cytokines and unique thymic antigen-presenting cells, are known to contribute to the development of these thymus-derived Tregs (tTregs).
Eirini Nikolouli, Yassin Elfaki, Susanne Herppich, Carsten Schelmbauer, Michael Delacher, Christine Falk, Ilgiz A. Mufazalov, Ari Waisman, Markus Feuerer, Jochen Huehn   +9 more
openaire   +3 more sources

Tregs and transplantation tolerance [PDF]

Journal of Clinical Investigation, 2004
The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes ...
Patrick T, Walsh, Devon K, Taylor, Laurence A, Turka   +2 more
openaire   +4 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg [PDF]

Frontiers in Immunology, 2018
We conducted an experimental database analysis to determine the expression of 61 CD4+ Th subset regulators in human and murine tissues, cells, and in T-regulatory cells (Treg) in physiological and pathological conditions. We made the following significant findings: (1) adipose tissues of diabetic patients with insulin resistance upregulated various Th ...
Keman Xu, Keman Xu, William Y. Yang, William Y. Yang, Gayani Kanchana Nanayakkara, Gayani Kanchana Nanayakkara, Ying Shao, Ying Shao, Fan Yang, Wenhui Hu, Wenhui Hu, Eric T. Choi, Eric T. Choi, Hong Wang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang   +17 more
openaire   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source