Results 31 to 40 of about 203,023 (389)

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]

, 2016
Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo, CARONNA, Roberto, CHIRLETTI, Piero, CIARDI, Antonio, DEL BENE, GABRIELLA, FARELLI, FRANCESCO, Focaccetti, Chiara, Longo, Flavia, MORELLI, Sergio, PACELLA, ILENIA, PICONESE, SILVIA, SACCO, LUCA, SCHINZARI, VALERIA, TIMPERI, ELEONORA, VESTRI, Anna Rita   +14 more
core   +1 more source

IL-35 promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms

JCI Insight, 2021
Tregs play vital roles in suppressing atherogenesis. Pathological conditions reshape Tregs and increase Treg-weakening plasticity. It remains unclear how Tregs preserve their function and how Tregs switch into alternative phenotypes in the environment of
Ying Shao, William Y. Yang, Fatma Saaoud, C. Drummer, Yu Sun, Keman Xu, Yifan Lu, Huimin Shan, E. Shevach, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +11 more
semanticscholar   +1 more source

Pathological conditions re-shape physiological Tregs into pathological Tregs [PDF]

Burns & Trauma, 2015
AbstractCD4+FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance, controlling acute and chronic inflammation, allergy, autoimmune diseases, and anti-cancer immune responses. Over the past 20 years, a significant progress has been made since Tregs were first characterized in
Yang, William Y, Shao, Ying, Lopez-Pastrana, Jahaira, Mai, Jietang, Wang, Hong, Yang, Xiao-feng   +5 more
openaire   +2 more sources

CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development

OncoImmunology, 2022
Current immunotherapies for lung cancer are only effective in a subset of patients. Identifying tumor-derived factors that facilitate immunosuppression offers the opportunity to develop novel strategies to supplement and improve current therapeutics.
Etienne S. Melese, Elizabeth Franks, Rachel A. Cederberg, Bryant T. Harbourne, Rocky Shi, Brennan J. Wadsworth, Jenna L. Collier, Elizabeth C. Halvorsen, Fraser Johnson, Jennifer Luu, Min Hee Oh, Vivian Lam, Gerald Krystal, Shelley B. Hoover, Mark Raffeld, R. Mark Simpson, Arun M. Unni, Wan L. Lam, Stephen Lam, Ninan Abraham, Kevin L. Bennewith, William W. Lockwood   +21 more
doaj   +1 more source

In utero Therapy for the Treatment of Sickle Cell Disease: Taking Advantage of the Fetal Immune System

Frontiers in Cell and Developmental Biology, 2021
Sickle Cell Disease (SCD) is an autosomal recessive disorder resulting from a β-globin gene missense mutation and is among the most prevalent severe monogenic disorders worldwide.
Alba Saenz de Villaverde Cortabarria, Laura Makhoul, John Strouboulis, Giovanna Lombardi, Eugene Oteng-Ntim, Panicos Shangaris, Panicos Shangaris   +6 more
doaj   +1 more source

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]

, 2018
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella   +14 more
core   +2 more sources

Vancomycin-induced gut microbiota dysbiosis aggravates allergic rhinitis in mice by altered short-chain fatty acids

Frontiers in Microbiology, 2022
ObjectiveThis study aims to explore how gut microbiota dysbiosis affects allergic rhinitis (AR) and whether short-chain fatty acids (SCFAs) play a role in this process.MethodsA mouse gut microbiota dysbiosis model was established by adding vancomycin to ...
Zhen Chen, Zhen Chen, Qingqing Xu, Qingqing Xu, Yang Liu, Yang Liu, Yihan Wei, Yihan Wei, Shancai He, Wei Lin, Wei Lin, Yingge Wang, Yingge Wang, Li Li, Yuanteng Xu, Yuanteng Xu   +15 more
doaj   +1 more source

Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective [PDF]

, 2015
Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression.
Ono, M, Tanaka, RJ
core   +1 more source

Tissue Tregs and Maintenance of Tissue Homeostasis

Frontiers in Cell and Developmental Biology, 2021
Regulatory T cells (Tregs) specifically expressing Forkhead box P3 (Foxp3) play roles in suppressing the immune response and maintaining immune homeostasis.
Qing Shao, J. Gu, Jinren Zhou, Qi Wang, Xiangyu Li, Zhenhua Deng, Ling Lu   +6 more
semanticscholar   +1 more source

Are We Ready for the Use of Foxp3+ Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation?

Journal of Transplantation, 2012
The existence of T-cell subsets naturally committed to perform immunoregulation has led to enthusiastic efforts to investigate their role in the immunopathogenesis of transplantation. Being able to modulate alloresponses, regulatory T cells could be used
Francisco Salcido-Ochoa, Nurhashikin Yusof, Susan Swee-Shan Hue, Doreen Haase, Terence Kee, Olaf Rotzschke   +5 more
doaj   +1 more source