Results 11 to 20 of about 103,024 (350)
Novel 1, 2, 4-Triazoles as Antifungal Agents
BioMed Research International, 2022 The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity.
Zahra Kazeminejad +5 more
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Synthesis methods of 1,2,3-/1,2,4-triazoles: A review
Frontiers in Chemistry, 2022 Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers 1,2,3-triazole and 1,2,4-triazole. Compounds containing a triazole are one of the significant heterocycles that exhibit broad biological activities, such as ...
J. Dai +3 more
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ACS Omega, 2021 A new series of 1,2,3-triazole hybrids containing either 2- or 4-hydroxyphenyl benzothiazole (2- or 4-HBT) and naphthalen-1-ol or 8-hydroxyquinoline (8-HQ) was synthesized in high yields and fully characterized.
Nidhi Nehra, Ram Kumar Tittal, V. Ghule
semanticscholar +1 more source
1,2,4-Triazoles as Important Antibacterial Agents
Pharmaceuticals, 2021 The global spread of drug resistance in bacteria requires new potent and safe antimicrobial agents. Compounds containing the 1,2,4-triazole ring in their structure are characterised by multidirectional biological activity.
M. Strzelecka, P. Świątek
semanticscholar +1 more source
Medicinal Chemistry Research, 2021 Due to the limited number of drugs in current clinical use, the diverse biological applications of furan have encouraged the preparation of a wide variety of thiosemicarbazide and triazole derivatives for the purpose of developing new drug agents.
Yusuf Sıcak
semanticscholar +1 more source
1,2,3-Triazoles as Biomimetics in Peptide Science
Molecules, 2021 Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo.
Naima Agouram +2 more
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Application of triazoles in the structural modification of natural products
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Nature products have been extensively used in the discovery and development of new drugs, as the most important source of drugs. The triazole ring is one of main pharmacophore of the nitrogen-containing heterocycles.
Hong-Yan Guo +3 more
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The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
Pharmaceutics, 2021 Second generation triazoles are widely used as first-line drugs for the treatment of invasive fungal infections, including aspergillosis and candidiasis. This class, along with itraconazole, voriconazole, posaconazole, and isavuconazole, is characterized
A. Czyrski +4 more
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An insight on medicinal attributes of 1,2,4-triazoles
European journal of medicinal chemistry, 2020 The present review aims to summarize the pharmacological profile of 1,2,4-triazole, one of the emerging privileged scaffold, as antifungal, antibacterial, anticancer, anticonvulsant, antituberculosis, antiviral, antiparasitic, analgesic and anti ...
R. Aggarwal, Garima Sumran
semanticscholar +1 more source
Molecules, 2001 The rearrangement of 4-methyl-3,5-diaryl-4H-1,2,4-triazoles to the corresponding 1-methyl-3,5-diaryl-1H-1,2,4-triazoles showed regioselectivity comparable to that observed for the alkylation of 3,5-diaryl-1H-1,2,4-triazoles.
Per H.J. Carlsen, Odd R. Gautun
doaj +1 more source