Results 91 to 100 of about 2,567 (176)

Tight junction formation in early Xenopus laevis embryos: identification and ultrastructural characterization of junctional crests and junctional vesicles [PDF]

, 2018
How tight junctions (TJ) form during early amphibian embryogenesis is still an open question. We used time-lapse video microscopy, scanning electron microscopy (SEM), TEM and freeze-fracture to gain new insight into TJ biogenesis in early clevages of ...
Cardellini, Pietro, Cirelli, Alessandro, Citi, Sandra   +2 more
core  

Intestinal Barrier Function in Gluten-Related Disorders [PDF]

, 2019
Gluten-related disorders include distinct disease entities, namely celiac disease, wheat-associated allergy and non-celiac gluten/wheat sensitivity. Despite having in common the contact of the gastrointestinal mucosa with components of wheat and other ...
Branchi, Federica, Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Moerkens, Renée, Schumann, Michael, Withoff, Sebo   +6 more
core   +2 more sources

ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42

Biology Open, 2015
Immunoglobulin-like domain containing receptor 1 (ILDR1) is a poorly characterized gene that was first identified in lymphoma cells. Mutations in ILDR1 are responsible for DFNB42, but the pathogenesis of hearing loss caused by ILDR1 mutations remains to ...
Qing Sang, Wen Li, Yao Xu, Ronggui Qu, Zhigang Xu, Ruizhi Feng, Li Jin, Lin He, Huawei Li, Lei Wang   +9 more
doaj   +1 more source

Tetraspanin CD9 limits mucosal healing in experimental colitis [PDF]

, 2017
Tetraspanins are a family of proteins with four transmembrane domains that associate between themselves and cluster with other partner proteins, conforming a distinct class of membrane domains, the tetraspanin-enriched microdomains (TEMs).
Arduise, Barreiro, Barreiro, Berditchevski, Boucheix, Cario, Castro-Sanchez, Chami, Charrin, Cooper, Froslie, Fukata, Fukata, Gutiérrez-López, Hemler, Iizuka, Inui, Khor, Kiesler, Kovalenko, Kovalenko, Le Naour, Leung, Mombaerts, Murayama, Natsui, Neurath, Okayasu, Ovalle, Perse, Pineton de Chambrun, Playford, Podolsky, Powner, Rakoff-Nahoum, Rocha-Perugini, Rutgeerts, Shah, Shi, Sinha, Smith, Tai, Tai, Takeda, Tang, Toyo-oka, Williams, Yáñez-Mó   +47 more
core   +4 more sources

Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues

Obesity Reviews, Volume 25, Issue 8, August 2024.
Summary Obesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease, diabetes, and cancer. A confluence of genetic polymorphisms, suboptimal dietary choices, and sedentary lifestyles significantly contribute to the elevated incidence of obesity.
Sara K. AlMarzooqi, Fajr Almarzooqi, Hana Q. Sadida, Jayakumar Jerobin, Ikhlak Ahmed, Abdul‐Badi Abou‐Samra, Khalid A. Fakhro, Punita Dhawan, Ajaz A. Bhat, Ammira S. Al‐Shabeeb Akil   +9 more
wiley   +1 more source

The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights

iScience
Summary: The tricellular tight junctions are crucial for the regulation of paracellular flux at tricellular junctions, where tricellulin (MARVELD2) and angulins (ILDR1, ILDR2, or LSR) are localized.
Florian Siegerist, Felix Kliewe, Elke Hammer, Paul Schakau, Joanne Ern Chi Soh, Claudia Weber, Maja Lindenmeyer, Simone Reichelt-Wurm, Vedran Drenic, Christos Chatziantoniou, Christos E. Chadjichristos, Yiying Zhang, Stefan Simm, Miriam C. Banas, Matthias Nauck, Uwe Völker, Nicole Endlich   +16 more
doaj   +1 more source

Mechanisms regulating intestinal barrier integrity and its pathological implications [PDF]

, 2018
The gastrointestinal tract is a specialized organ in which dynamic interactions between host cells and the complex environment occur in addition to food digestion.
CHAITHANYA, LAKSHMI CHELAKKOT GOVINDALAYA, Ghim, Jaewang, Ryu, Sung Ho   +2 more
core   +1 more source

Cell‐permeable JNK‐inhibitory peptide regulates intestinal barrier function and inflammation to ameliorate necrotizing enterocolitis

Journal of Cellular and Molecular Medicine, Volume 28, Issue 14, July 2024.
Abstract Intestinal dysbiosis is believed to play a role in the development of necrotizing enterocolitis (NEC). The efficacy of JNK‐inhibitory peptide (CPJIP) in treating NEC was assessed. Treatment with CPJIP led to a notable reduction in p‐JNK expression in IEC‐6 cells and NEC mice.
Chaozhi Bu, Mengyuan Hu, Yinglin Su, Fuqiang Yuan, Yiting Zhang, Jing Xia, Zhenyu Jia, Le Zhang   +7 more
wiley   +1 more source

Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures.

PLoS ONE, 2019
Ischemic stroke has been shown to induce breakdown of the blood-brain barrier, although these changes are not fully characterized. Oxygen-glucose deprivation (OGD) has been used to investigate the effects of ischemia in cultured brain capillary ...
Erica Tornabene, Hans Christian Cederberg Helms, Stine Falsig Pedersen, Birger Brodin   +3 more
doaj   +1 more source

Effect of cAMP derivates on assembly and maintenance of tight junctions in human umbilical vein endothelial cells

BMC Cell Biology, 2010
Background Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on
Beese Michaela, Wyss Kristin, Haubitz Marion, Kirsch Torsten   +3 more
doaj   +1 more source