Results 71 to 80 of about 1,774 (156)

Lipolysis‐Stimulated Lipoprotein Receptor Gene Variants as a Cause of Progressive Familial Intrahepatic Cholestasis: A Case Report

Hepatology Research, Volume 55, Issue 11, Page 1551-1556, November 2025.
This article talks about a rare genetic condition called LSR deficiency, which causes liver issues such as another condition called PFIC. It describes the case of a 4‐year‐old girl who had yellowing of the skin, slow growth, and liver problems and was diagnosed with LSR deficiency through genetic testing. The study suggests that LSR could be a new type
Yugo Takaki, Shuichiro Umetsu, Yoshihiko Sugino, Takahiro Yamashita, Takehiko Doi, Kazuo Imagawa, Shogo Ito, Yutaro Mihara, Hisamitsu Hayashi, Ayano Inui   +9 more
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Macronutrients as Regulators of Intestinal Epithelial Permeability: Where Do We Stand?

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 3, May 2025.
ABSTRACT The intestinal barrier function (IBF) is essential for intestinal homeostasis. Its alterations have been linked to intestinal and systemic disease. Regulation of intestinal permeability is key in the maintenance of the IBF, in which the intestinal epithelium and tight junctions, the mucus layer, sIgA, and antimicrobial peptides are important ...
Olga Martínez‐Augustin, Mireia Tena‐Garitaonaindia, Diego Ceacero‐Heras, Ángela Jiménez‐Ortas, Juan J. Enguix‐Huete, Ana I. Álvarez‐Mercado, Guillermo Ruiz‐Henares, Carlos J. Aranda, Reyes Gámez‐Belmonte, Fermín Sánchez de Medina   +9 more
wiley   +1 more source

4D pathology: translating dynamic epithelial tubulogenesis to prostate cancer pathology

Histopathology, Volume 86, Issue 5, Page 681-693, April 2025.
Rethinking prostate cancer growth patterns in the context of epithelial tubule formation, elongation, and branching. The Gleason score is the gold standard for grading of prostate cancer (PCa) and is assessed by assigning specific grades to different microscopical growth patterns.
Hridya Harikumar, Martin E van Royen, Geert JLH van Leenders   +2 more
wiley   +1 more source

Systematic review: The gut microbiota as a link between colorectal cancer and obesity

Obesity Reviews, Volume 26, Issue 4, April 2025.
Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer.
Antonio Jesús Ruiz‐Malagón, María Jesús Rodríguez‐Sojo, Eduardo Redondo, María Elena Rodríguez‐Cabezas, Julio Gálvez, Alba Rodríguez‐Nogales   +5 more
wiley   +1 more source

Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development

Advanced Therapeutics, Volume 8, Issue 3, March 2025.
Polymeric nanoparticles are a promising approach for targeted drug delivery in case of patients with inflammatory bowel disease (IBD). IBD is a complex chronic gastrointestinal disease with compromised gastrointestinal barrier integrity, mucosal barrier alterations, altered cell surface receptor patterns, and oxidative stress. This review discusses how
Elena Gardey, Johannes C. Brendel, Andreas Stallmach   +2 more
wiley   +1 more source

The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights

iScience
Summary: The tricellular tight junctions are crucial for the regulation of paracellular flux at tricellular junctions, where tricellulin (MARVELD2) and angulins (ILDR1, ILDR2, or LSR) are localized.
Florian Siegerist, Felix Kliewe, Elke Hammer, Paul Schakau, Joanne Ern Chi Soh, Claudia Weber, Maja Lindenmeyer, Simone Reichelt-Wurm, Vedran Drenic, Christos Chatziantoniou, Christos E. Chadjichristos, Yiying Zhang, Stefan Simm, Miriam C. Banas, Matthias Nauck, Uwe Völker, Nicole Endlich   +16 more
doaj   +1 more source

ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42

Biology Open, 2015
Immunoglobulin-like domain containing receptor 1 (ILDR1) is a poorly characterized gene that was first identified in lymphoma cells. Mutations in ILDR1 are responsible for DFNB42, but the pathogenesis of hearing loss caused by ILDR1 mutations remains to ...
Qing Sang, Wen Li, Yao Xu, Ronggui Qu, Zhigang Xu, Ruizhi Feng, Li Jin, Lin He, Huawei Li, Lei Wang   +9 more
doaj   +1 more source

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source

Tricellulin is regulated via interleukin 13 receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis

, 2018
In the two inflammatory bowel diseases, ulcerative colitis (UC) and Crohn’s disease (CD), altered expression of tight junction (TJ) proteins leads to an impaired epithelial barrier including increased uptake of luminal antigens supporting the ...
Turner, JR, Krug, SM, Bojarski, C, Lee, IM, Fromm, M, Schulzke, JD, Richter, JF, Fromm, A, Dames, P   +8 more
core   +1 more source