Results 71 to 80 of about 2,596 (169)

Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer

Scientific Reports, 2016
AbstractAccumulating evidence has shown that dysregulation of tight junctions (TJs) is involved in tumor development and progression. In this study, we investigated the expression and subcellular distribution of tricellulin, which constitutes tricellular TJs, using human pancreatic adenocarcinomas.
Akira Takasawa, Masaki Murata, Kumi Takasawa, Yusuke Ono, Makoto Osanai, Satoshi Tanaka, Masanori Nojima, Tsuyoshi Kono, Koichi Hirata, Takashi Kojima, Norimasa Sawada   +10 more
openaire   +2 more sources

Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells.

PLoS ONE, 2017
Tricellular tight junctions (tTJs) are specialized structures that occur where the corners of three cells meet to seal adjacent intercellular space. The molecular components of tTJs include tricellulin (TRIC) and lipolysis-stimulated lipoprotein receptor
Kenichi Takano, Takuya Kakuki, Yakuto Kaneko, Takayuki Kohno, Shin Kikuchi, Tetsuo Himi, Takashi Kojima   +6 more
doaj   +1 more source

Tight junction disruption induced by type 3 secretion system effectors injected by Enteropathogenic and Enterohemorrhagic Escherichia coli

Frontiers in Cellular and Infection Microbiology, 2016
The intestinal epithelium consists of a single cell layer, which is a critical selectively permeable barrier to both absorb nutrients and avoid the entry of potentially harmful entities, including microorganisms. Epithelial cells are held together by the
Paul Ugalde-Silva, Octavio Gonzalez-Lugo, Fernando Navarro-Garcia   +2 more
doaj   +1 more source

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]

, 2019
Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara, Bouchaud, Grégory, Costa, Ana, Denery-Papini, Sandra, Díaz-Perales, Araceli, E.M. Willemsen, Linette, Garrido-Arandia, María, Gavrovic-Jankulovic, Marija, H.M. van Bilsen, Jolanda, Hayen, Simone, L. Bavaro, Simona, L. Roggen, Erwin, Lozano-Ojalvo, Daniel, M. Antunes, Célia, Wróblewska, Mónica   +14 more
core   +1 more source

Loss of intestinal epithelial barrier function in Salmonella Enteritidis infection [PDF]

, 2014
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704Intestinal infection with Salmonella enterica serotype Enteritidis, a food-borne infection spread to humans especially through contaminated eggs and egg-products as well as undercooked ...
Brufau Bonet, M. Teresa (Maria Teresa), Ferrer i Roig, Ruth, Martín Venegas, Raquel   +2 more
core  

Tricellulin regulates junctional tension of epithelial cells at tricellular contacts via Cdc42 [PDF]

Journal of Cell Science, 2014
When the surface view of each epithelial cell is compared with a polygon, its sides correspond to cell–cell junctions, while its vertices correspond to tricellular contacts, whose roles in epithelial cell morphogenesis have not been well studied. Here, we show that tricellulin, which is localized at tricellular contacts, regulates F-actin organization ...
Yukako, Oda, Tetsuhisa, Otani, Junichi, Ikenouchi, Mikio, Furuse   +3 more
openaire   +2 more sources

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family

BMC Cell Biology, 2009
Background Tight junctions are an intercellular adhesion complex of epithelial and endothelial cells, and form a paracellular barrier that restricts the diffusion of solutes on the basis of size and charge.
Balda Maria S, Rodrigues Nelio TL, Steed Emily, Matter Karl   +3 more
doaj   +1 more source

Mechanisms regulating intestinal barrier integrity and its pathological implications [PDF]

, 2018
The gastrointestinal tract is a specialized organ in which dynamic interactions between host cells and the complex environment occur in addition to food digestion.
CHAITHANYA, LAKSHMI CHELAKKOT GOVINDALAYA, Ghim, Jaewang, Ryu, Sung Ho   +2 more
core   +1 more source

Tight junction formation in early Xenopus laevis embryos: identification and ultrastructural characterization of junctional crests and junctional vesicles [PDF]

, 2018
How tight junctions (TJ) form during early amphibian embryogenesis is still an open question. We used time-lapse video microscopy, scanning electron microscopy (SEM), TEM and freeze-fracture to gain new insight into TJ biogenesis in early clevages of ...
Cardellini, Pietro, Cirelli, Alessandro, Citi, Sandra   +2 more
core  

The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights

iScience
Summary: The tricellular tight junctions are crucial for the regulation of paracellular flux at tricellular junctions, where tricellulin (MARVELD2) and angulins (ILDR1, ILDR2, or LSR) are localized.
Florian Siegerist, Felix Kliewe, Elke Hammer, Paul Schakau, Joanne Ern Chi Soh, Claudia Weber, Maja Lindenmeyer, Simone Reichelt-Wurm, Vedran Drenic, Christos Chatziantoniou, Christos E. Chadjichristos, Yiying Zhang, Stefan Simm, Miriam C. Banas, Matthias Nauck, Uwe Völker, Nicole Endlich   +16 more
doaj   +1 more source