Results 61 to 70 of about 1,774 (156)

Tricellulin, occludin and claudin-3 expression in salmon intestine and kidney during salinity adaptation

, 2012
Molecular regulation of tight junctions in osmoregulatory epithelia of euryhaline fishes must be extensive during ontogeny and acclimation to salinity changes.
Tipsmark, Christian Kølbæk, Madsen, Steffen; id_orcid   +1 more
core   +1 more source

Dietary Deoxynivalenol (DON) May Impair the Epithelial Barrier and Modulate the Cytokine Signaling in the Intestine of Atlantic Salmon (Salmo salar)

Toxins, 2018
Impaired growth, immunity, and intestinal barrier in mammals, poultry, and carp have been attributed to the mycotoxin deoxynivalenol (DON). The increased use of plant ingredients in aquaculture feed implies a risk for contamination with mycotoxins.
Torfinn Moldal, Aksel Bernhoft, Grethe Rosenlund, Magne Kaldhusdal, Erling Olaf Koppang   +4 more
doaj   +1 more source

Mechanistic Landscape and Farm to Fork Control Strategies for Streptococcus suis: An Emerging Foodborne Threat

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Streptococcus suis (S. suis) is an emerging zoonotic agent that now rivals classical food‐borne pathogens in its global clinical burden of meningitis and septic shock. Recent epidemiological syntheses covering more than 30 countries now list over 1600 laboratory‐confirmed human cases with a pooled case‐fatality of about 12%, climbing beyond 18% in East
Wangyuan Yao, Meili Chen, Hongkai Ren, Qingqing Luo, Xuyuan Wang, Md. Akhtar, Zeeshan Ahmad Bhutta, Lianci Peng, Muhammad Yasir Nawaz, Mohammad Mehedi Hasan, Md. F. Kulyar, Rendong Fang, Zhong Peng   +12 more
wiley   +1 more source

Air Pollution‐Induced Epigenetic Regulation in Respiratory Diseases: Mechanisms, Dysregulation, and Therapeutic Opportunities

MedComm – Future Medicine, Volume 4, Issue 4, December 2025.
Air pollution, a major global health hazard, contributes to asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer via four core epigenetic pathways (DNA/RNA methylation, noncoding RNAs, and histone modifications), shaping gene expression and driving disease pathogenesis.
Ruitong Zeng, Jiliu Liu, Guoping Li, Junyi Wang, Anying Xiong, Ying Xiong, Xiang He   +6 more
wiley   +1 more source

Effect of the p.P69H mutation on the localization and tricellulin recruitment function of ILDR1.

, 2015
(A-G) Parental EpH4 cells, (A) LSR knockdown cells. (B) LSR knockdown cells stably expressing the mock FLAG vector (C) or wild-type (WT) human ILDR1. Immunostaining of (D) p.P69H, (E) p.R97Q, (F) or p.Q195X (G) was performed using anti-FLAG mAb (green ...
Kyoung Yeul Lee (691098), Woong-Yang Park (207980), Veronica Kim (691101), Mun Young Chang (691100), Seung-Ha Oh (449124), Mikio Furuse (621728), Tomohito Higashi (621727), Ah Reum Kim (449120), Shin-ichiro Kitajiri (691099), Byung Yoon Choi (407079), Nayoung K. D. Kim (691097), Dongsup Kim (50568), Min Young Kim (313098)   +12 more
core   +1 more source

Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer

Scientific Reports, 2016
AbstractAccumulating evidence has shown that dysregulation of tight junctions (TJs) is involved in tumor development and progression. In this study, we investigated the expression and subcellular distribution of tricellulin, which constitutes tricellular TJs, using human pancreatic adenocarcinomas.
Akira Takasawa, Masaki Murata, Kumi Takasawa, Yusuke Ono, Makoto Osanai, Satoshi Tanaka, Masanori Nojima, Tsuyoshi Kono, Koichi Hirata, Takashi Kojima, Norimasa Sawada   +10 more
openaire   +2 more sources

Tricellulin regulates junctional tension of epithelial cells at tricellular contacts via Cdc42 [PDF]

Journal of Cell Science, 2014
When the surface view of each epithelial cell is compared with a polygon, its sides correspond to cell–cell junctions, while its vertices correspond to tricellular contacts, whose roles in epithelial cell morphogenesis have not been well studied. Here, we show that tricellulin, which is localized at tricellular contacts, regulates F-actin organization ...
Yukako, Oda, Tetsuhisa, Otani, Junichi, Ikenouchi, Mikio, Furuse   +3 more
openaire   +2 more sources

Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten‐Induced Cytotoxicity and Inflammation

Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.
Celiac disease (CD) is triggered by gluten in genetically predisposed individuals and is mainly treated with a gluten‐free diet. However, symptoms may persist. This review explores how certain Bifidobacterium strains may reduce inflammation and gluten toxicity through six mechanisms, including modulation of immune responses and gut microbiota.
Taynara Cipriano Scherer, Ivan De Marco, Natália Regina Coldebella Ferreira, Tatiana Colombo Pimentel, Marciane Magnani, Guilherme de Souza Hassemer, Amanda Bagolin do Nascimento, Silvani Verruck   +7 more
wiley   +1 more source

Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells.

PLoS ONE, 2017
Tricellular tight junctions (tTJs) are specialized structures that occur where the corners of three cells meet to seal adjacent intercellular space. The molecular components of tTJs include tricellulin (TRIC) and lipolysis-stimulated lipoprotein receptor
Kenichi Takano, Takuya Kakuki, Yakuto Kaneko, Takayuki Kohno, Shin Kikuchi, Tetsuo Himi, Takashi Kojima   +6 more
doaj   +1 more source

Tight junction disruption induced by type 3 secretion system effectors injected by Enteropathogenic and Enterohemorrhagic Escherichia coli

Frontiers in Cellular and Infection Microbiology, 2016
The intestinal epithelium consists of a single cell layer, which is a critical selectively permeable barrier to both absorb nutrients and avoid the entry of potentially harmful entities, including microorganisms. Epithelial cells are held together by the
Paul Ugalde-Silva, Octavio Gonzalez-Lugo, Fernando Navarro-Garcia   +2 more
doaj   +1 more source